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STAT6
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

STAT6

Gene description

Signal transducer and activator of transcription 6, interleukin-4 induced

Protein class

Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

17
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA001861
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
N/A
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

STAT6 (HGNC Symbol)

Synonyms

D12S1644, IL-4-STAT

Description

Signal transducer and activator of transcription 6, interleukin-4 induced (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Chromosome

12

Cytoband

q13.3

Chromosome location (bp)

57095408 - 57132139

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166888 (version 83.38)

Entrez gene

6778

UniProt

P42226 (UniProt - Evidence at protein level)

neXtProt

NX_P42226

Antibodypedia

STAT6 antibodies

PROTEIN BROWSER

«
STAT6-001
STAT6-002
STAT6-003
STAT6-004
STAT6-006
STAT6-008
STAT6-010
STAT6-013
STAT6-014
STAT6-015
STAT6-018
STAT6-019
STAT6-020
STAT6-021
STAT6-022
STAT6-023
STAT6-024
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STAT6-001
ENSP00000300134
ENST00000300134
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0002296 [T-helper 1 cell lineage commitment]
GO:0002829 [negative regulation of type 2 immune response]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0033598 [mammary gland epithelial cell proliferation]
GO:0034097 [response to cytokine]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042802 [identical protein binding]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048295 [positive regulation of isotype switching to IgE isotypes]
GO:0060443 [mammary gland morphogenesis]
GO:0070301 [cellular response to hydrogen peroxide]
GO:1902170 [cellular response to reactive nitrogen species]
Show all
847 aa
94.1 kDa
No 0
STAT6-002
ENSP00000451742
ENST00000556155
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
847 aa
94.1 kDa
No 0
STAT6-003
ENSP00000438451
ENST00000543873
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
847 aa
94.1 kDa
No 0
STAT6-004
ENSP00000401486
ENST00000454075
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
847 aa
94.1 kDa
No 0
STAT6-006
ENSP00000444530
ENST00000537215
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
737 aa
81.7 kDa
No 0
STAT6-008
ENSP00000445409
ENST00000538913
P42226 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0019903 [protein phosphatase binding]
GO:0032481 [positive regulation of type I interferon production]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0042802 [identical protein binding]
GO:0045087 [innate immune response]
Show all
737 aa
81.7 kDa
No 0
STAT6-010
ENSP00000451074
ENST00000553499
G3V370 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
154 aa
17.8 kDa
No 0
STAT6-013
ENSP00000450428
ENST00000555318
H0YIY2 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
155 aa
17.3 kDa
No 0
STAT6-014
ENSP00000451546
ENST00000553533
H0YJH6 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
290 aa
32.5 kDa
No 0
STAT6-015
ENSP00000450921
ENST00000555375
G3V2X7 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
154 aa
17.9 kDa
No 0
STAT6-018
ENSP00000450732
ENST00000553275
G3V2L2 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
64 aa
7.4 kDa
No 0
STAT6-019
ENSP00000451209
ENST00000554825
G3V3E9 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
103 aa
11.7 kDa
No 0
STAT6-020
ENSP00000452203
ENST00000553397
G3V568 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
144 aa
16.7 kDa
No 0
STAT6-021
ENSP00000452394
ENST00000555849
G3V5K5 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
159 aa
18.3 kDa
No 0
STAT6-022
ENSP00000450747
ENST00000557635
G3V2M3 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
74 aa
8.3 kDa
No 0
STAT6-023
ENSP00000450665
ENST00000554663
G3V2H4 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
105 aa
11.8 kDa
No 0
STAT6-024
ENSP00000452373
ENST00000556259
G3V5I8 [Direct mapping]
Signal transducer and activator of transcription 6
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004871 [signal transducer activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007165 [signal transduction]
Show all
141 aa
16.4 kDa
No 0

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