Expression of AR in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene nameⁱ Gene name according to HGNC.	AR
Gene descriptionⁱ Gene description according to HGNC.	Androgen receptor
Protein classⁱ Protein class the gene product belongs to according to selected gene lists. List of protein classes.	Cancer-related genes Disease related genes FDA approved drug targets Nuclear receptors Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localizationⁱ Protein localization predicted from several bioinformatic algorithms. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcribed from this gene as defined by Ensembl.	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryⁱ

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, LHCN-M2, RH-30)
HPA (normal tissue):	Mixed

Protein evidenceⁱ

Evidence at protein level

Protein expression
normal tissueⁱ

Nuclear expression in several tissues, mainly in reproductive organs.

ANTIBODY IHC RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.	Antibody staining consistent with RNA expression data.
Reliability scoreⁱ Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data. Read more	Supported based on 2 antibodies. CAB000001 , CAB065764
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PROGNOSTIC SUMMARYⁱ Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.
Prognostic marker in renal cancer (favourable) and liver cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEWⁱ

TCGA datasetⁱ
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more

RNA cancer category: Mixed

PROTEIN EXPRESSIONⁱ

STAINING SUMMARYⁱ

CAB000001	CAB065764

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	AR (HGNC Symbol)
Synonyms	AIS, DHTR, HUMARA, NR3C4, SBMA, SMAX1
Description	Androgen receptor (HGNC Symbol)
Entrez gene summary	The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	X
Cytoband	q12
Chromosome location (bp)	67544032 - 67730619
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000169083 (version 83.38)
Entrez gene	367
UniProt	P10275 (UniProt - Evidence at protein level)
neXtProt	NX_P10275
Antibodypedia	AR antibodies

PROTEIN BROWSERⁱ

AR-001	AR-002	AR-004	AR-201	AR-202	AR-203	AR-204

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AR-001 ENSP00000363822 ENST00000374690	A0A0B4J1T2 [Direct mapping] Androgen receptor Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0003073 [regulation of systemic arterial blood pressure] GO:0003382 [epithelial cell morphogenesis] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005496 [steroid binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007283 [spermatogenesis] GO:0007338 [single fertilization] GO:0008270 [zinc ion binding] GO:0008584 [male gonad development] GO:0009566 [fertilization] GO:0009987 [cellular process] GO:0010468 [regulation of gene expression] GO:0019102 [male somatic sex determination] GO:0030521 [androgen receptor signaling pathway] GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway] GO:0033327 [Leydig cell differentiation] GO:0035264 [multicellular organism growth] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043410 [positive regulation of MAPK cascade] GO:0043565 [sequence-specific DNA binding] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0048608 [reproductive structure development] GO:0048638 [regulation of developmental growth] GO:0048645 [organ formation] GO:0048808 [male genitalia morphogenesis] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0050790 [regulation of catalytic activity] GO:0060520 [activation of prostate induction by androgen receptor signaling pathway] GO:0060571 [morphogenesis of an epithelial fold] GO:0060599 [lateral sprouting involved in mammary gland duct morphogenesis] GO:0060685 [regulation of prostatic bud formation] GO:0060736 [prostate gland growth] GO:0060740 [prostate gland epithelium morphogenesis] GO:0060742 [epithelial cell differentiation involved in prostate gland development] GO:0060748 [tertiary branching involved in mammary gland duct morphogenesis] GO:0060749 [mammary gland alveolus development] GO:0061458 [reproductive system development] GO:0070974 [POU domain binding] GO:0072520 [seminiferous tubule development] Show all	920 aa 99.2 kDa	No	0
AR-002 ENSP00000379358 ENST00000396043	P10275 [Direct mapping] Androgen receptor F1D8N5 [Target identity:100%; Query identity:100%] Androgen nuclear receptor variant 2 Show all	Nuclear receptors THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005102 [receptor binding] GO:0005497 [androgen binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006810 [transport] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0007267 [cell-cell signaling] GO:0007548 [sex differentiation] GO:0008013 [beta-catenin binding] GO:0008134 [transcription factor binding] GO:0008270 [zinc ion binding] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0016049 [cell growth] GO:0019899 [enzyme binding] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0030850 [prostate gland development] GO:0042327 [positive regulation of phosphorylation] GO:0043234 [protein complex] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045597 [positive regulation of cell differentiation] GO:0045720 [negative regulation of integrin biosynthetic process] GO:0045726 [positive regulation of integrin biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0045945 [positive regulation of transcription from RNA polymerase III promoter] GO:0046983 [protein dimerization activity] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051117 [ATPase binding] GO:0051259 [protein oligomerization] GO:0090003 [regulation of establishment of protein localization to plasma membrane] GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway] Show all	388 aa 44.6 kDa	No	0
AR-004 ENSP00000421155 ENST00000504326	E7EVX6 [Direct mapping] Androgen receptor Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030521 [androgen receptor signaling pathway] GO:0043565 [sequence-specific DNA binding] Show all	644 aa 67.4 kDa	No	0
AR-201 ENSP00000379359 ENST00000396044	F5GZG9 [Direct mapping] Androgen receptor Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030521 [androgen receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] Show all	734 aa 77 kDa	No	0
AR-202 ENSP00000482407 ENST00000612010	A0A087WZ66 [Direct mapping] Androgen receptor Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030521 [androgen receptor signaling pathway] GO:0043565 [sequence-specific DNA binding] Show all	642 aa 67.1 kDa	No	0
AR-203 ENSP00000484033 ENST00000612452	A0A087X1B6 [Direct mapping] Androgen receptor Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0004882 [androgen receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030521 [androgen receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] Show all	737 aa 79.4 kDa	No	0
AR-204 ENSP00000479013 ENST00000613054	A0A087WUX9 [Direct mapping] Androgen receptor Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004882 [androgen receptor activity] GO:0005496 [steroid binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0030521 [androgen receptor signaling pathway] Show all	572 aa 59.4 kDa	No	0