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Most cancer tissues showed moderate cytoplasmic immunoreactivity. Several melanomas, lymphomas along with a few cases of duct carcinomas of breast, seminomas, liver and stomach cancers were strongly stained.
GENE INFORMATION
Gene name
ARL13B (HGNC Symbol)
Synonyms
ARL2L1, DKFZp761H079, JBTS8
Description
ADP-ribosylation factor-like 13B (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the ADP-ribosylation factor-like family. The encoded protein is a small GTPase that contains both N-terminal and C-terminal guanine nucleotide-binding motifs. This protein is localized in the cilia and plays a role in cilia formation and in maintenance of cilia. Mutations in this gene are the cause of Joubert syndrome 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]