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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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MAP3K11
  • TISSUE

  • premium

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

MAP3K11

Gene description

Mitogen-activated protein kinase kinase kinase 11

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB010165
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB010165

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant cells generally displayed moderate cytoplasmic immunoreactivity. Several cases of malignant melanomas, pancreatic, liver, prostate, breast and ovarian cancers showed strong staining.

GENE INFORMATION

Gene name

MAP3K11 (HGNC Symbol)

Synonyms

MEKK11, MLK3, PTK1, SPRK

Description

Mitogen-activated protein kinase kinase kinase 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

65597755 - 65615382

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000173327 (version 83.38)

Entrez gene

4296

UniProt

Q16584 (UniProt - Evidence at protein level)

neXtProt

NX_Q16584

Antibodypedia

MAP3K11 antibodies

PROTEIN BROWSER

MAP3K11-001
MAP3K11-004
MAP3K11-006
MAP3K11-012
MAP3K11-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MAP3K11-001
ENSP00000309597
ENST00000309100
Q16584 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
A0A024R5E6 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase kinase 11, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004706 [JUN kinase kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0007254 [JNK cascade]
GO:0007256 [activation of JNKK activity]
GO:0007257 [activation of JUN kinase activity]
GO:0008219 [cell death]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031434 [mitogen-activated protein kinase kinase binding]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
GO:0048365 [Rac GTPase binding]
Show all
847 aa
92.7 kDa
No 0
MAP3K11-004
ENSP00000433886
ENST00000530153
Q16584 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004706 [JUN kinase kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005874 [microtubule]
GO:0006468 [protein phosphorylation]
GO:0007017 [microtubule-based process]
GO:0007254 [JNK cascade]
GO:0007257 [activation of JUN kinase activity]
GO:0008283 [cell proliferation]
GO:0016020 [membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0046777 [protein autophosphorylation]
Show all
590 aa
65.3 kDa
No 0
MAP3K11-006
ENSP00000432068
ENST00000532507
E9PID4 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
263 aa
27.6 kDa
No 0
MAP3K11-012
ENSP00000435970
ENST00000526293
E9PRQ2 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
111 aa
12.3 kDa
No 0
MAP3K11-013
ENSP00000435237
ENST00000529839
E9PLB1 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 11
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
97 aa
10.7 kDa
No 0

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