Malignant cells generally displayed moderate cytoplasmic immunoreactivity. Several cases of malignant melanomas, pancreatic, liver, prostate, breast and ovarian cancers showed strong staining.
MAP3K11 (HGNC Symbol)
MEKK11, MLK3, PTK1, SPRK
Mitogen-activated protein kinase kinase kinase 11 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]