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Malignant cells were in general negative. Weak to moderate nuclear positivity was observed in a few testicular cancers.
GENE INFORMATION
Gene name
PNMA1 (HGNC Symbol)
Synonyms
MA1
Description
Paraneoplastic Ma antigen 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a neuron- and testis-specific protein that is also expressed in some paraneoplastic syndromes affecting the nervous system. Some patients with neurologic disorders develop antibodies against the protein encoded by this gene. The identification of the antineuronal antibodies in the sera of these patients has facilitated the diagnosis of paraneoplastic neurological disorders and the early detection of the associated tumors. [provided by RefSeq, Feb 2014]