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Several cases of urothelial cancer and squamous cell carcinomas showed moderate to strong membranous immunoreactivity. Most other malignant cells were negative.
GENE INFORMATION
Gene name
THBD (HGNC Symbol)
Synonyms
CD141
Description
Thrombomodulin (HGNC Symbol)
Entrez gene summary
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]