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Moderate cytoplasmic staining was displayed in a few cases of glioma. Weak cytoplasmic positivity was observed in a subset of tumor cells in a few cases of several other cancer types.
GENE INFORMATION
Gene name
SLITRK4 (HGNC Symbol)
Synonyms
DKFZp547M2010
Description
SLIT and NTRK-like family, member 4 (HGNC Symbol)
Entrez gene summary
This gene encodes a transmembrane protein belonging to the the SLITRK family. These family members include two N-terminal leucine-rich repeat domains similar to those found in the axonal growth-controlling protein SLIT, as well as C-terminal regions similar to neurotrophin receptors. Studies of an homologous protein in mouse suggest that this family member functions to suppress neurite outgrowth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]