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ANXA2

GENERAL INFORMATION

Gene namei

 ANXA2

Gene descriptioni

 Annexin A2

Protein classi

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localizationi

 Intracellular

Number of transcriptsi

 27
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidencei

 Evidence at protein level

Protein expression
normal tissuei

 Cytoplasmic staining in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex.

Reliability scorei

 Approved based on 1 antibody.
CAB004311
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PROGNOSTIC SUMMARYi
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), liver cancer (unfavourable), urothelial cancer (unfavourable), endometrial cancer (favourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Liver cancer p<0.001
Urothelial cancer p<0.001
Endometrial cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi
CAB004311

GENE INFORMATIONi

Gene name

 ANXA2 (HGNC Symbol)

Synonyms

 ANX2, ANX2L4, CAL1H, LIP2, LPC2D

Description

 Annexin A2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 60347134 - 60402883

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000182718 (version 83.38)

Entrez gene

 302

UniProt

 P07355 (UniProt - Evidence at protein level)

neXtProt

 NX_P07355

Antibodypedia

 ANXA2 antibodies

PROTEIN BROWSERi
«
ANXA2-001
ANXA2-002
ANXA2-005
ANXA2-006
ANXA2-009
ANXA2-010
ANXA2-011
ANXA2-013
ANXA2-016
ANXA2-019
ANXA2-020
ANXA2-021
ANXA2-023
ANXA2-024
ANXA2-025
ANXA2-026
ANXA2-027
ANXA2-028
ANXA2-030
ANXA2-031
ANXA2-032
ANXA2-033
ANXA2-034
ANXA2-035
ANXA2-036
ANXA2-037
ANXA2-038
»

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ANXA2-001
ENSP00000379342
ENST00000396024
P07355 [Direct mapping]
Annexin A2
A0A024R5Z7 [Target identity:100%; Query identity:100%]
Annexin
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006900 [membrane budding]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0030546 [receptor activator activity]
GO:0031012 [extracellular matrix]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0043086 [negative regulation of catalytic activity]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0048306 [calcium-dependent protein binding]
GO:0051290 [protein heterotetramerization]
GO:0070062 [extracellular exosome]
GO:1900121 [negative regulation of receptor binding]
GO:1990667 [PCSK9-AnxA2 complex]
GO:2000273 [positive regulation of receptor activity]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-002
ENSP00000387545
ENST00000451270
P07355 [Direct mapping]
Annexin A2
A0A024R5Z7 [Target identity:100%; Query identity:100%]
Annexin
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006900 [membrane budding]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0030546 [receptor activator activity]
GO:0031012 [extracellular matrix]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0043086 [negative regulation of catalytic activity]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0048306 [calcium-dependent protein binding]
GO:0051290 [protein heterotetramerization]
GO:0070062 [extracellular exosome]
GO:1900121 [negative regulation of receptor binding]
GO:1990667 [PCSK9-AnxA2 complex]
GO:2000273 [positive regulation of receptor activity]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-005
ENSP00000411352
ENST00000421017
P07355 [Direct mapping]
Annexin A2
A0A024R5Z7 [Target identity:100%; Query identity:100%]
Annexin
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001765 [membrane raft assembly]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005811 [lipid particle]
GO:0005886 [plasma membrane]
GO:0006900 [membrane budding]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0030496 [midbody]
GO:0030546 [receptor activator activity]
GO:0031012 [extracellular matrix]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0036035 [osteoclast development]
GO:0042470 [melanosome]
GO:0043086 [negative regulation of catalytic activity]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0048306 [calcium-dependent protein binding]
GO:0051290 [protein heterotetramerization]
GO:0070062 [extracellular exosome]
GO:1900121 [negative regulation of receptor binding]
GO:1990667 [PCSK9-AnxA2 complex]
GO:2000273 [positive regulation of receptor activity]
Show all
 339 aa
38.6 kDa 		No 0
ANXA2-006
ENSP00000346032
ENST00000332680
P07355 [Direct mapping]
Annexin A2
Show all
Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001726 [ruffle]
GO:0001765 [membrane raft assembly]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002020 [protease binding]
GO:0002091 [negative regulation of receptor internalization]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0005546 [phosphatidylinositol-4,5-bisphosphate binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005811 [lipid particle]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006900 [membrane budding]
GO:0007589 [body fluid secretion]
GO:0008092 [cytoskeletal protein binding]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0017137 [Rab GTPase binding]
GO:0019834 [phospholipase A2 inhibitor activity]
GO:0019897 [extrinsic component of plasma membrane]
GO:0030199 [collagen fibril organization]
GO:0030496 [midbody]
GO:0030546 [receptor activator activity]
GO:0031012 [extracellular matrix]
GO:0031340 [positive regulation of vesicle fusion]
GO:0031902 [late endosome membrane]
GO:0031982 [vesicle]
GO:0032804 [negative regulation of low-density lipoprotein particle receptor catabolic process]
GO:0035749 [myelin sheath adaxonal region]
GO:0036035 [osteoclast development]
GO:0042383 [sarcolemma]
GO:0042470 [melanosome]
GO:0042730 [fibrinolysis]
GO:0043086 [negative regulation of catalytic activity]
GO:0043220 [Schmidt-Lanterman incisure]
GO:0043234 [protein complex]
GO:0044354 [macropinosome]
GO:0044548 [S100 protein binding]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048306 [calcium-dependent protein binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051099 [positive regulation of binding]
GO:0051290 [protein heterotetramerization]
GO:0070062 [extracellular exosome]
GO:0072661 [protein targeting to plasma membrane]
GO:0097066 [response to thyroid hormone]
GO:1900121 [negative regulation of receptor binding]
GO:1990667 [PCSK9-AnxA2 complex]
GO:2000273 [positive regulation of receptor activity]
Show all
 357 aa
40.4 kDa 		No 0
ANXA2-009
ENSP00000453859
ENST00000559818
H0YN42 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 256 aa
28.8 kDa 		No 0
ANXA2-010
ENSP00000453039
ENST00000558985
H0YL33 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 142 aa
16.4 kDa 		No 0
ANXA2-011
ENSP00000453174
ENST00000559725
H0YLE2 [Direct mapping]
Annexin A2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
Show all
 45 aa
5.3 kDa 		No 0
ANXA2-013
ENSP00000453945
ENST00000558169
H0YNB8 [Direct mapping]
Annexin A2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 47 aa
5.1 kDa 		No 0
ANXA2-016
ENSP00000453566
ENST00000559370
H0YMD9 [Direct mapping]
Annexin A2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 65 aa
7.1 kDa 		No 0
ANXA2-019
ENSP00000452895
ENST00000557906
H0YKS4 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 176 aa
19.5 kDa 		No 0
ANXA2-020
ENSP00000452858
ENST00000560468
H0YKL9 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 110 aa
12.1 kDa 		No 0
ANXA2-021
ENSP00000452981
ENST00000558558
H0YKX9 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 134 aa
14.6 kDa 		No 0
ANXA2-023
ENSP00000453841
ENST00000560466
H0YN28 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 139 aa
16.1 kDa 		No 0
ANXA2-024
ENSP00000453869
ENST00000559113
H0YN52 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
Show all
 59 aa
6.8 kDa 		No 0
ANXA2-025
ENSP00000454096
ENST00000558132
H0YNP5 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
Show all
 175 aa
19.7 kDa 		No 0
ANXA2-026
ENSP00000453694
ENST00000559956
H0YKZ7 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 119 aa
13 kDa 		No 0
ANXA2-027
ENSP00000453000
ENST00000559467
H0YKZ7 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 119 aa
13 kDa 		No 0
ANXA2-028
ENSP00000453770
ENST00000559780
H0YMW4 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 146 aa
16.2 kDa 		No 0
ANXA2-030
ENSP00000453742
ENST00000557986
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 4 aa
0.5 kDa 		No 0
ANXA2-031
ENSP00000452921
ENST00000560165
H0YKS4 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 176 aa
19.5 kDa 		No 0
ANXA2-032
ENSP00000453556
ENST00000560367
H0YMD0 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 227 aa
25.3 kDa 		No 0
ANXA2-033
ENSP00000453925
ENST00000558998
H0YNA0 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 79 aa
9.1 kDa 		No 0
ANXA2-034
ENSP00000453579
ENST00000560389
H0YKS4 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 176 aa
19.5 kDa 		No 0
ANXA2-035
ENSP00000453739
ENST00000558986
H0YMT9 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 133 aa
14.5 kDa 		No 0
ANXA2-036
ENSP00000453663
ENST00000559350
H0YMM1 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 149 aa
16.5 kDa 		No 0
ANXA2-037
ENSP00000453464
ENST00000559176
H0YM50 [Direct mapping]
Annexin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 248 aa
28.3 kDa 		No 0
ANXA2-038
ENSP00000452958
ENST00000557904
H0YKV8 [Direct mapping]
Annexin A2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004859 [phospholipase inhibitor activity]
GO:0005509 [calcium ion binding]
GO:0005544 [calcium-dependent phospholipid binding]
GO:0008092 [cytoskeletal protein binding]
GO:0043086 [negative regulation of catalytic activity]
Show all
 81 aa
9 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.