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PAPSS2
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

PAPSS2

Gene description

3'-phosphoadenosine 5'-phosphosulfate synthase 2

Protein class

Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ)
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in melanoma (unfavourable), thyroid cancer (unfavourable) and pancreatic cancer (favourable).
Melanoma p<0.001
Thyroid cancer p<0.001
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

PAPSS2 (HGNC Symbol)

Synonyms

ATPSK2

Description

3'-phosphoadenosine 5'-phosphosulfate synthase 2 (HGNC Symbol)

Entrez gene summary

Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

Chromosome location (bp)

87659613 - 87747705

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198682 (version 83.38)

Entrez gene

9060

UniProt

O95340 (UniProt - Evidence at protein level)

neXtProt

NX_O95340

Antibodypedia

PAPSS2 antibodies

PROTEIN BROWSER

PAPSS2-001
PAPSS2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAPSS2-001
ENSP00000354436
ENST00000361175
O95340 [Direct mapping]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase
Q5TB52 [Target identity:100%; Query identity:100%]
3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b; cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNA
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0001501 [skeletal system development]
GO:0004020 [adenylylsulfate kinase activity]
GO:0004781 [sulfate adenylyltransferase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0016310 [phosphorylation]
GO:0016779 [nucleotidyltransferase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
Show all
614 aa
69.5 kDa
No 0
PAPSS2-201
ENSP00000406157
ENST00000456849
O95340 [Direct mapping]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0001501 [skeletal system development]
GO:0004020 [adenylylsulfate kinase activity]
GO:0004781 [sulfate adenylyltransferase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0016779 [nucleotidyltransferase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
GO:0060348 [bone development]
Show all
619 aa
70 kDa
No 0

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