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PAPSS2

GENERAL INFORMATION

Gene name

 PAPSS2

Gene description

 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable), thyroid cancer (unfavourable) and pancreatic cancer (favourable).
Melanoma p<0.001
Thyroid cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PAPSS2 (HGNC Symbol)

Synonyms

 ATPSK2

Description

 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (HGNC Symbol)

Entrez gene summary

 Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

Chromosome location (bp)

 87659613 - 87747705

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198682 (version 83.38)

Entrez gene

 9060

UniProt

 O95340 (UniProt - Evidence at protein level)

neXtProt

 NX_O95340

Antibodypedia

 PAPSS2 antibodies

PROTEIN BROWSER
PAPSS2-001
PAPSS2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAPSS2-001
ENSP00000354436
ENST00000361175
O95340 [Direct mapping]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase
Q5TB52 [Target identity:100%; Query identity:100%]
3'-phosphoadenosine 5'-phosphosulfate synthase 2, isoform CRA_b; cDNA, FLJ92929, highly similar to Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2), mRNA
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0001501 [skeletal system development]
GO:0004020 [adenylylsulfate kinase activity]
GO:0004781 [sulfate adenylyltransferase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0016310 [phosphorylation]
GO:0016779 [nucleotidyltransferase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
Show all
 614 aa
69.5 kDa 		No 0
PAPSS2-201
ENSP00000406157
ENST00000456849
O95340 [Direct mapping]
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Sulfate adenylyltransferase Adenylyl-sulfate kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000103 [sulfate assimilation]
GO:0001501 [skeletal system development]
GO:0004020 [adenylylsulfate kinase activity]
GO:0004781 [sulfate adenylyltransferase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0007596 [blood coagulation]
GO:0016310 [phosphorylation]
GO:0016779 [nucleotidyltransferase activity]
GO:0030203 [glycosaminoglycan metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050428 [3'-phosphoadenosine 5'-phosphosulfate biosynthetic process]
GO:0060348 [bone development]
Show all
 619 aa
70 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.