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Lymphomas displayed moderate to strong cytoplasmic staining along with a case of carcinoid. Moderate cytoplasmic staining was observed in occasional cases of gliomas. Remaining cancer tissues were generally negative.
Most cancer tissues showed weak to moderate cytoplasmic and nuclear immunoreactivity. Colorectal, breast and lymphomas were strongly stained in a few cases. Several gliomas, skin and testicular cancers were negative.
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]