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RNA cancer category: Tissue enriched (liver cancer)
PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY
GENE INFORMATION
Gene name
ANG (HGNC Symbol)
Synonyms
RAA1, RNASE5
Description
Angiogenin, ribonuclease, RNase A family, 5 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014]