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AQP1

GENERAL INFORMATION

Gene namei

 AQP1

Gene descriptioni

 Aquaporin 1 (Colton blood group)

Protein classi

 Blood group antigen proteins
Predicted membrane proteins
Transporters

Predicted localizationi

 Membrane

Number of transcriptsi

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21, U-2 OS, WM-115)
HPA (normal tissue):Expressed in all

Protein evidencei

 Evidence at protein level

Protein expression
normal tissuei

 Selective membranous expression in renal tubules, exocrine pancreas, bile ducts, subsets of cells in the intestine, myoepithelial cells of breast and endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.

Reliability scorei

 Supported based on 2 antibodies.
HPA019206 , CAB001707
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PROGNOSTIC SUMMARYi
Prognostic marker in renal cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi
TCGA dataseti
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi
HPA019206
CAB001707

GENE INFORMATIONi

Gene name

 AQP1 (HGNC Symbol)

Synonyms

 CHIP28, CO

Description

 Aquaporin 1 (Colton blood group) (HGNC Symbol)

Entrez gene summary

 Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

 7

Cytoband

 p14.3

Chromosome location (bp)

 30911855 - 30925516

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000240583 (version 83.38)

Entrez gene

 358

UniProt

 P29972 (UniProt - Evidence at protein level)

neXtProt

 NX_P29972

Antibodypedia

 AQP1 antibodies

PROTEIN BROWSERi
AQP1-001
AQP1-002
AQP1-003
AQP1-201

PROTEIN INFORMATIONi

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AQP1-001
ENSP00000311165
ENST00000311813
P29972 [Direct mapping]
Aquaporin-1
A0A024RA31 [Target identity:100%; Query identity:100%]
Aquaporin 1 (Channel-forming integral protein, 28kDa); HCG39137, isoform CRA_a
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003094 [glomerular filtration]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0006972 [hyperosmotic response]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009725 [response to hormone]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019233 [sensory perception of pain]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030104 [water homeostasis]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0032809 [neuronal cell body membrane]
GO:0032940 [secretion by cell]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033363 [secretory granule organization]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042060 [wound healing]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042538 [hyperosmotic salinity response]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043627 [response to estrogen]
GO:0043679 [axon terminus]
GO:0044241 [lipid digestion]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046875 [ephrin receptor binding]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048593 [camera-type eye morphogenesis]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051458 [corticotropin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070295 [renal water absorption]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072220 [metanephric descending thin limb development]
GO:0072230 [metanephric proximal straight tubule development]
GO:0072232 [metanephric proximal convoluted tubule segment 2 development]
GO:0072239 [metanephric glomerulus vasculature development]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 269 aa
28.5 kDa 		No 6
AQP1-002
ENSP00000387178
ENST00000409611
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 218 aa
23.4 kDa 		No 3
AQP1-003
ENSP00000386712
ENST00000409899
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 154 aa
16.7 kDa 		No 3
AQP1-201
ENSP00000405698
ENST00000441328
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
 186 aa
20 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.