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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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AQP1
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene namei

Gene name according to HGNC.

AQP1

Gene descriptioni

Gene description according to HGNC.

Aquaporin 1 (Colton blood group)

Protein classi

Protein class the gene product belongs to according to selected gene lists. List of protein classes.

Blood group antigen proteins
Predicted membrane proteins
Transporters

Predicted localizationi

Protein localization predicted from several bioinformatic algorithms.

Read more

Membrane

Number of transcriptsi

Number of protein-coding transcribed from this gene as defined by Ensembl.

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA categoryi

RNA category is based on mRNA expression levels in the analyzed samples (RNA assay description). The categories include: tissue/cell line enriched, group enriched, tissue/cell line enhanced, expressed in all, mixed and not detected. RNA category is calculated separately for The Cancer Genome Atlas (TCGA) data from cancer tissues and internally generated Human Protein Atlas (HPA) data from normal tissues and cell lines.

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21, U-2 OS, WM-115)
HPA (normal tissue):Expressed in all

Protein evidencei

Protein evidence scores are generated from several independent sources and are classified as evidence at i) protein level, ii) transcript level, iii) no evidence, or iv) not available.

Evidence at protein level

Protein expression
normal tissuei

A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation.

"Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile.

Read more

Selective membranous expression in renal tubules, exocrine pancreas, bile ducts, subsets of cells in the intestine, myoepithelial cells of breast and endothelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
descriptioni

Standardized explanatory sentences with additional information required for full understanding of the knowledge-based expression profile.

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene. Antibody staining in cells/structures not annotated, view images.

Reliability scorei

Reliability score (score description), divided into Supported, Approved, or Uncertain, is evaluated in normal tissues and based on consistency between the staining pattern of one antibody or several antibodies with RNA-seq data and available gene/protein characterization data.

Read more

Supported based on 2 antibodies.
HPA019206 , CAB001707
SHOW MORE

PROGNOSTIC SUMMARYi

Kaplan-Meier plots for all cancers where high expression of this gene has significant (p<0.001) association with patient survival are shown in this summary. Whether the prognosis is favourable or unfavourable is indicated in brackets. Each Kaplan-Meier plot is clickable and redirects to a detailed page that includes individual expression and survival data for patients with the selected cancer.

Prognostic marker in renal cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
Show all

RNA EXPRESSION OVERVIEWi

RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).

TCGA dataseti
RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. To access cancer specific RNA and prognostic data, click on the cancer name.

Read more
RNA cancer category: Expressed in all

PROTEIN EXPRESSIONi

Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

For histological reference, visit the histological dictionary.

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARYi

For each cancer, the fraction of samples with protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the left). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The mouse-over function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

HPA019206
CAB001707

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Renal cancers showed moderate to strong cytoplasmic/membranous immunoreactivity. Remaining tumors were mainly negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summaryi

A manually written summary of the overall protein expression pattern across the analyzed cancer tissues.

Cases of renal, colorectal, gastric and liver cancers showed moderate to strong membraneous positivity. Remaining malignancies were negative.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

AQP1 (HGNC Symbol)

Synonyms

CHIP28, CO

Description

Aquaporin 1 (Colton blood group) (HGNC Symbol)

Entrez gene summary

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Chromosome

7

Cytoband

p14.3

Chromosome location (bp)

30911855 - 30925516

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000240583 (version 83.38)

Entrez gene

358

UniProt

P29972 (UniProt - Evidence at protein level)

neXtProt

NX_P29972

Antibodypedia

AQP1 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

AQP1-001
AQP1-002
AQP1-003
AQP1-201

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

AQP1-001
ENSP00000311165
ENST00000311813
P29972 [Direct mapping]
Aquaporin-1
A0A024RA31 [Target identity:100%; Query identity:100%]
Aquaporin 1 (Channel-forming integral protein, 28kDa); HCG39137, isoform CRA_a
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003094 [glomerular filtration]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0006972 [hyperosmotic response]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009725 [response to hormone]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0010592 [positive regulation of lamellipodium assembly]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019233 [sensory perception of pain]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030104 [water homeostasis]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030335 [positive regulation of cell migration]
GO:0030424 [axon]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0032809 [neuronal cell body membrane]
GO:0032940 [secretion by cell]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033363 [secretory granule organization]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042060 [wound healing]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0042538 [hyperosmotic salinity response]
GO:0043005 [neuron projection]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043627 [response to estrogen]
GO:0043679 [axon terminus]
GO:0044241 [lipid digestion]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046875 [ephrin receptor binding]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0048593 [camera-type eye morphogenesis]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051458 [corticotropin secretion]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070295 [renal water absorption]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072220 [metanephric descending thin limb development]
GO:0072230 [metanephric proximal straight tubule development]
GO:0072232 [metanephric proximal convoluted tubule segment 2 development]
GO:0072239 [metanephric glomerulus vasculature development]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
269 aa
28.5 kDa
No 6
AQP1-002
ENSP00000387178
ENST00000409611
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
218 aa
23.4 kDa
No 3
AQP1-003
ENSP00000386712
ENST00000409899
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
154 aa
16.7 kDa
No 3
AQP1-201
ENSP00000405698
ENST00000441328
P29972 [Direct mapping]
Aquaporin-1
Show all
Blood group antigen proteins
Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003091 [renal water homeostasis]
GO:0003097 [renal water transport]
GO:0005215 [transporter activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005267 [potassium channel activity]
GO:0005372 [water transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006182 [cGMP biosynthetic process]
GO:0006810 [transport]
GO:0006813 [potassium ion transport]
GO:0006833 [water transport]
GO:0006884 [cell volume homeostasis]
GO:0008519 [ammonium transmembrane transporter activity]
GO:0009925 [basal plasma membrane]
GO:0009992 [cellular water homeostasis]
GO:0015079 [potassium ion transmembrane transporter activity]
GO:0015168 [glycerol transmembrane transporter activity]
GO:0015250 [water channel activity]
GO:0015254 [glycerol channel activity]
GO:0015670 [carbon dioxide transport]
GO:0015696 [ammonium transport]
GO:0015701 [bicarbonate transport]
GO:0015793 [glycerol transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019725 [cellular homeostasis]
GO:0020003 [symbiont-containing vacuole]
GO:0020005 [symbiont-containing vacuole membrane]
GO:0021670 [lateral ventricle development]
GO:0022857 [transmembrane transporter activity]
GO:0030157 [pancreatic juice secretion]
GO:0030184 [nitric oxide transmembrane transporter activity]
GO:0030185 [nitric oxide transport]
GO:0030950 [establishment or maintenance of actin cytoskeleton polarity]
GO:0031526 [brush border membrane]
GO:0031965 [nuclear membrane]
GO:0033326 [cerebrospinal fluid secretion]
GO:0033554 [cellular response to stress]
GO:0034644 [cellular response to UV]
GO:0035377 [transepithelial water transport]
GO:0035378 [carbon dioxide transmembrane transport]
GO:0035379 [carbon dioxide transmembrane transporter activity]
GO:0042383 [sarcolemma]
GO:0042476 [odontogenesis]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0044281 [small molecule metabolic process]
GO:0045177 [apical part of cell]
GO:0045766 [positive regulation of angiogenesis]
GO:0046878 [positive regulation of saliva secretion]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0050891 [multicellular organismal water homeostasis]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0071241 [cellular response to inorganic substance]
GO:0071260 [cellular response to mechanical stimulus]
GO:0071280 [cellular response to copper ion]
GO:0071288 [cellular response to mercury ion]
GO:0071300 [cellular response to retinoic acid]
GO:0071320 [cellular response to cAMP]
GO:0071456 [cellular response to hypoxia]
GO:0071472 [cellular response to salt stress]
GO:0071474 [cellular hyperosmotic response]
GO:0071549 [cellular response to dexamethasone stimulus]
GO:0071732 [cellular response to nitric oxide]
GO:0071805 [potassium ion transmembrane transport]
GO:0072488 [ammonium transmembrane transport]
GO:0085018 [maintenance of symbiont-containing vacuole by host]
GO:0098655 [cation transmembrane transport]
Show all
186 aa
20 kDa
No 3

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