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Cancer tissues displayed moderate to strong cytoplasmic staining. Several cases of endometrial, skin, testicular and pancreatic cancers were weakly stained or negative.
Cancer cells in general showed weak to moderate staining. Most lymphomas, testicular and renal cancers were negative.
GENE INFORMATION
Gene name
NFS1 (HGNC Symbol)
Synonyms
IscS, NifS
Description
NFS1 cysteine desulfurase (HGNC Symbol)
Entrez gene summary
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Transferases Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)