The human protein atlas blog


ASCB/EMBO meeting starts on the 2 December

2017-11-29
Cell Atlas Human Protein Atlas

The American Society for Cell Biology (ASCB) and the European Molecular Biology Organization (EMBO) jointly organize the first international conference on cell biology of brain. The ASCB/EMBO meeting takes place in Philadelphia on the 2-4 of December 2017.

The conference brings together a program covering presentations from molecular structure and function analysis to signalling pathways, immunity and cellular interplay in organoids.

At the meeting, Dr. Emma Lundberg presents "What is an atlas and why is it important to build?" in a subgroup aiming to discuss the creation of a multiscale, multidimensional Human Cell Atlas...Read more


NFIL3 a protein that follows the winter season

2017-11-24
Cell Atlas cells Immunofluorescence microscopy

Staining of NFIL3 (green) in nuclear bodies with DNA (blue) and microtubules (red) in A-431 cells.

Staining of NFIL3 (green) in nuclear bodies with DNA (blue) and microtubules (red) in A-431 cells. Many human genes follow a so called circadian clock and research has shown that some of those genes themselves follow the seasons (Dopico et al. 2015). When winter is coming, you sense it and your genes know it too. Expression of one of those genes, NFIL3, peaks during December until February and has its lowest expression during the summer months.

NFIL3 is a transcriptional regulator involved in regulation of immune processes. Like many other transcription regulators it localizes to nuclear bodies as seen on the Cell Atlas images and binds to specific DNA motifs...Read more


Prognostic genes in pancreatic cancer

2017-11-17
Cancer Immunohistochemistry Pancreatic cancer Pathology Atlas TCGA tissue

Figure 1. Immunohistochemical staining of MUC1 shows differential expression pattern, high (left panel) and low (right panel) in

Next in our series of articles on cancer is Pancreatic cancer, a relatively rare cancer associated with very poor prognosis. The vast majority of tumors originate from ductal cells and a small fraction are endocrine tumors. Over 80% of pancreatic cancers develop at ages above 60 years and most tumors are detected at late stages of the disease when the cancer has spread beyond the pancreas.

There is a great need for biomarkers to facilitate early detection and help establishment of diagnosis. Smoking, obesity, physical inactivity and long-lasting inflammation in the pancreas are some of the factors that lead to an increased risk of pancreatic cancer...Read more


Wellness Profiling program presented at the EMBL organised symposium - From Single to Multi-omics

2017-11-10
blood samples Human Protein Atlas SCAPISAffinity proteomics Wellness Wellness project

At the EMBO|EMBL symposia "From Single to Multi-omics: Applications and Challenges in Data Integration" in Heidelberg, Germany, on November 13, Dr Linn Fagerberg presents the talk entitled "Integrative omics profiling within the Swedish SCAPIS SciLifeLab (S3) Wellness Profiling program". The talk focuses on the integration of data retrieved from the analysis of biological samples collected within the SCAPIS project using different technological platforms. On the same day, Dr Fredrik Edfors participates in the poster session with a poster entitled "Gene specific correlation between protein and RNA"...Read more


Proteomic analysis of cell cycle progression reveal mitotic substages

2017-11-02
Affinity proteomics Cell Atlas Cell cycle Immunofluorescence

Examples of spindle phenotypes (Bipole, Collapsed, Multipole and Monopole)

A key feature and a critical first step in understanding cell division and proliferation lies in characterizing the temporal regulation of protein abundance. A collaborative publication "Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS" was recently published in eLife.

The Cell atlas team from Sweden joined forces with Dr Tony Ly and Professor Angus Lamond from the University of Dundee, to perform a proteome-wide analysis of changes in protein abundance and phosphorylation across the cell cycle...Read more


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