The human protein atlas blog


ASCB/EMBO meeting starts on the 2 December

2017-11-29
Cell Atlas Human Protein Atlas

The American Society for Cell Biology (ASCB) and the European Molecular Biology Organization (EMBO) jointly organize the first international conference on cell biology of brain. The ASCB/EMBO meeting takes place in Philadelphia on the 2-4 of December 2017.

The conference brings together a program covering presentations from molecular structure and function analysis to signalling pathways, immunity and cellular interplay in organoids.

At the meeting, Dr. Emma Lundberg presents "What is an atlas and why is it important to build?" in a subgroup aiming to discuss the creation of a multiscale, multidimensional Human Cell Atlas...Read more


NFIL3 a protein that follows the winter season

2017-11-24
Cell Atlas cells Immunofluorescence microscopy

Staining of NFIL3 (green) in nuclear bodies with DNA (blue) and microtubules (red) in A-431 cells.

Staining of NFIL3 (green) in nuclear bodies with DNA (blue) and microtubules (red) in A-431 cells. Many human genes follow a so called circadian clock and research has shown that some of those genes themselves follow the seasons (Dopico et al. 2015). When winter is coming, you sense it and your genes know it too. Expression of one of those genes, NFIL3, peaks during December until February and has its lowest expression during the summer months.

NFIL3 is a transcriptional regulator involved in regulation of immune processes. Like many other transcription regulators it localizes to nuclear bodies as seen on the Cell Atlas images and binds to specific DNA motifs...Read more


Proteomic analysis of cell cycle progression reveal mitotic substages

2017-11-02
Affinity proteomics Cell Atlas Cell cycle Immunofluorescence

Examples of spindle phenotypes (Bipole, Collapsed, Multipole and Monopole)

A key feature and a critical first step in understanding cell division and proliferation lies in characterizing the temporal regulation of protein abundance. A collaborative publication "Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS" was recently published in eLife.

The Cell atlas team from Sweden joined forces with Dr Tony Ly and Professor Angus Lamond from the University of Dundee, to perform a proteome-wide analysis of changes in protein abundance and phosphorylation across the cell cycle...Read more


Chan Zuckerberg funds pilot project within the Human Protein Atlas

2017-10-19
Cell Atlas Chan Zucherberg Initiative Human Protein Atlas

The Human Protein Atlas at the Science for Life Laboratory (SciLifeLab) are teaming up with the Chan Zuckerberg Initiative to strengthen research in cell biology and proteomics.

The Chan Zuckerberg Initiative, which was founded by Facebook founder Mark Zuckerberg and his wife, Dr. Priscilla Chan, provides financial and engineering support for the Human Cell Atlas, an ambitious international collaboration that aims to create a reference atlas of all cells in the healthy human body as a resource for studies of health and disease...Read more


The HPA at the Image-based Cell Atlas Meeting

2017-10-06
Cell Atlas Chan-Zuckerberg Initiative Image analysis Immunofluorescence microscopy Proteomics

Participants at the Image-based Cell Atlas Meeting 2017

The importance of mapping the human cell has become recognized as one of the key challenges in modern biology. Image-based assays offer a data-rich medium of studying cells and their proteins in situ. As such, several large-scale initiatives for studying cellular biology using image-based assays have been founded in recent years...Read more


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