The human protein atlas blog


Prognostic genes in pancreatic cancer

2017-11-17
Cancer Immunohistochemistry Pancreatic cancer Pathology Atlas TCGA tissue

Figure 1. Immunohistochemical staining of MUC1 shows differential expression pattern, high (left panel) and low (right panel) in

Next in our series of articles on cancer is Pancreatic cancer, a relatively rare cancer associated with very poor prognosis. The vast majority of tumors originate from ductal cells and a small fraction are endocrine tumors. Over 80% of pancreatic cancers develop at ages above 60 years and most tumors are detected at late stages of the disease when the cancer has spread beyond the pancreas.

There is a great need for biomarkers to facilitate early detection and help establishment of diagnosis. Smoking, obesity, physical inactivity and long-lasting inflammation in the pancreas are some of the factors that lead to an increased risk of pancreatic cancer...Read more


Ovarian Cancer Awareness Month

2017-09-29
Cancer Immunohistochemistry Life Science Ovarian cancer awareness Pathology Atlas Plasma Profilling TCGA tissue

Figure 1. Immunohistochemical staining of EPCAM using antibody CAB055098 shows differential expression, both high (left panel) and low (right panel) in samples from ovarian cancer patients.

In this week's Pathology Atlas blog post, we highlight genes with prognostic association to ovarian cancer , as September is National Ovarian Cancer Awareness Month in the US. Ovarian cancer is the fifth most frequent cause of cancer death in women, and 50% of all ovarian cancers are diagnosed in women older than 65 years of age.

Epithelial ovarian carcinoma is one of the most common gynecologic malignancy. There are five subtypes of epithelial ovarian carcinoma, of which high-grade serous carcinoma is the most common...Read more


Awareness for prostate cancer

2017-09-27
European Prostate Cancer Awareness Day Immunohistochemistry Life Science Pathology Atlas Prostate cancer Prostate Cancer Awareness Month TCGA tissue

Figure 1. Immunohistochemical staining of ODF2 using antibody HPA001874 shows differential expression in samples from prostate cancer patients.

As part of the release of the Pathology Atlas, the Human Protein Atlas Blog presents brief and informative summaries of most cancers, and highlight genes with prognostic association in the different cancer forms. The Pathology Atlas is an open access database which includes quantitative transcriptomics data and spatial proteomics data of the major human cancer types that have been analyzed using a systems level approach.

We focus on prostate cancer in this week's blog post to highlight Prostate Cancer Awareness Month in North America and the European Prostate Cancer Awareness Day on the 27th of September...Read more


Focusing on prognostic genes in breast cancer

2017-09-07
Breast Cancer Cancer Cancer Genome Atlas Immunohistochemistry Pathology Atlas TCGA tissue

Figure 1. Immunohistochemical staining of CBX3 using antibody HPA004902 shows a differential nuclear expression in samples from breast cancer patients.

The Pathology Atlas, recently published in Science presents key proteins associated with different cancer types. This week's news article will focus on breast cancer and proteins related to cancer prognosis.

Breast cancer is the most common invasive cancer form in women worldwide. The cancer can roughly be classified as ductal or lobular breast cancer depending on the origin. The majority of breast cancers develop sporadically, but for 5-10% of patients there is an inherited factor associated with increased breast cancer risk, namely the BRCA1 and BRCA2 genes. Women with abnormal BRCA1 or BRCA2 have higher risk of developing breast cancer...Read more


Crystallins are proteins expressed in the human eye with a long life

2017-07-22
Eye Image of the week Immunocytochemistry Immunohistochemistry Lens proteins Pathology tissue Tissue Atlas

The beta-crystallin B2 protein, encoded by the CRYBB2 gene, is a very important structural component of the human eye lens. Immunohistochemical staining of CRYBB2 protein shows specific expression in the lens.

Previously we have highlighted proteins expressed in the human neural retina. This week's article emphasizes the cellular structure and molecular dynamics of the lens.

The main function of the lens is to focus light on the retina. The passage of light through the cornea, lens and vitreous all the way to the retinal layer of the eye is only possible due to transparency of the tissue. Although the lens is very protein-rich, light absorption and light scattering in the lens is minimal.

The lens comprises non-diving lens cells which are mainly composed of ordered proteins called crystallins...Read more


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