Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific ABCA13 FLJ33876, FLJ33951 ENSG00000179869 ATP-binding cassette, sub-family A (ABC1), member 13 7 48171458-48647496 Predicted membrane proteins Evidence at transcript level HPA063601 Approved Vesicles
Centrosome
Cytosol Mixed Tissue enriched 10 bone marrow: 29.4 testis: 3.0 ABCB7 ABC7, ASAT, Atm1p, EST140535 ENSG00000131269 ATP-binding cassette, sub-family B (MDR/TAP), member 7 X 75053172-75156732 Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA034982 Approved Supported Mitochondria Renal cancer:5.31e-6 (favourable) Expressed in all Expressed in all parathyroid gland: 21.3 ABCB8 EST328128, M-ABC1, MABC1 ENSG00000197150 ATP-binding cassette, sub-family B (MDR/TAP), member 8 7 151028422-151047782 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA045187 Approved Supported Nucleus
Mitochondria Pancreatic cancer:3.34e-4 (favourable), Renal cancer:5.88e-4 (favourable), Head and neck cancer:5.91e-4 (favourable) Expressed in all Expressed in all thyroid gland: 17.0 ABCB9 EST122234 ENSG00000150967 ATP-binding cassette, sub-family B (MDR/TAP), member 9 12 122920951-122981649 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB033052, HPA035113, HPA035114 Approved Supported Vesicles Glioma:4.62e-4 (unfavourable) Mixed Tissue enhanced testis: 23.9 cerebral cortex: 12.1 ABCG1 ABC8 ENSG00000160179 ATP-binding cassette, sub-family G (WHITE), member 1 21 42199689-42297244 Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA031470, HPA031471 Approved Supported Golgi apparatus
Vesicles Renal cancer:7.16e-6 (favourable) Expressed in all Expressed in all spleen: 43.7 ABCG4 WHITE2 ENSG00000172350 ATP-binding cassette, sub-family G (WHITE), member 4 11 119149012-119162653 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA040312 Uncertain Not detected Group enriched 6 cerebral cortex: 6.6;parathyroid gland: 4.0;testis: 5.1 seminal vesicle: 0.8 ABCG8 GBD4 ENSG00000143921 ATP-binding cassette, sub-family G (WHITE), member 8 2 43838964-43878466 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA019556 Uncertain Uncertain Vesicles Tissue enriched Group enriched 25 duodenum: 51.4;liver: 34.1;small intestine: 56.7 gallbladder: 1.8 AC171558.1 ENSG00000274792 Unmapped 386278-387620 Predicted membrane proteins Evidence at transcript level HPA057442 Uncertain Uncertain Centrosome Tissue enriched 11 testis: 4.3 cerebral cortex: 0.4 AC171558.2 ENSG00000275249 Unmapped 372322-373405 Predicted membrane proteins Evidence at transcript level HPA058889 Uncertain Tissue enriched 26 testis: 2.5 all non-specific tissues: 0.0 ACKR1 CCBP1, CD234, DARC, Dfy, FY, GPD ENSG00000213088 Atypical chemokine receptor 1 (Duffy blood group) 1 159203307-159206500 Blood group antigen proteins, CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA016421, HPA017672 Supported Cervical cancer:2.52e-5 (favourable), Liver cancer:1.48e-4 (favourable), Thyroid cancer:9.76e-4 (unfavourable) Expressed in all Mixed adipose tissue: 111.8 ACKR2 CCBP2, CCR10, CCR9, CMKBR9, D6 ENSG00000144648 Atypical chemokine receptor 2 3 42804752-42887974 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013819, HPA073493 Supported Supported Nucleoplasm
Vesicles
Cytosol Mixed Tissue enhanced placenta: 22.8 adipose tissue: 5.2 ACKR3 CMKOR1, CXCR7, GPR159, RDC1 ENSG00000144476 Atypical chemokine receptor 3 2 236567787-236582358 Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA032003, HPA049718 Approved Supported Vesicles
Plasma membrane Renal cancer:1.76e-6 (unfavourable), Stomach cancer:2.01e-4 (unfavourable), Urothelial cancer:2.93e-4 (unfavourable), Cervical cancer:4.64e-4 (unfavourable) Expressed in all Expressed in all placenta: 175.2 ACKR4 CCBP2, CCR11, CCRL1, CCX-CKR, PPR1, VSHK1 ENSG00000129048 Atypical chemokine receptor 4 3 132597237-132618967 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA027595 Uncertain Cytosol Mixed Mixed duodenum: 19.7 ADCY5 AC5 ENSG00000173175 Adenylate cyclase 5 3 123282296-123449758 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA017730, HPA077682 Uncertain Uncertain Intermediate filaments Renal cancer:7.46e-6 (favourable) Mixed Tissue enhanced heart muscle: 72.9 seminal vesicle: 29.7 ADCYAP1R1 PAC1, PAC1R, PACAPR ENSG00000078549 Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 7 31052461-31111479 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA049877 Approved Uncertain Vesicles Endometrial cancer:5.78e-4 (favourable) Tissue enriched Tissue enhanced cerebral cortex: 137.5;fallopian tube: 46.5 cervix, uterine: 20.6 ADGRA1 GPR123, KIAA1828 ENSG00000197177 Adhesion G protein-coupled receptor A1 10 133070929-133131675 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA042773 Approved Tissue enriched Tissue enhanced adrenal gland: 4.9;cerebral cortex: 22.5 fallopian tube: 3.1 ADGRA2 DKFZp434C211, DKFZp434J0911, FLJ14390, GPR124, KIAA1531, TEM5 ENSG00000020181 Adhesion G protein-coupled receptor A2 8 37784191-37844896 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA012393 Uncertain Renal cancer:3.18e-7 (unfavourable) Expressed in all Expressed in all seminal vesicle: 86.1 ADGRA3 FLJ38547, GPR125, PGR21 ENSG00000152990 Adhesion G protein-coupled receptor A3 4 22345071-22516054 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA008904 Uncertain Expressed in all Expressed in all thyroid gland: 42.3 ADGRB2 BAI2 ENSG00000121753 Adhesion G protein-coupled receptor B2 1 31727117-31764893 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA052612, HPA054617 Supported Centrosome Lung cancer:4.02e-5 (unfavourable), Breast cancer:6.46e-4 (favourable) Tissue enhanced Tissue enriched 14 cerebral cortex: 72.5 adrenal gland: 5.1 ADGRD1 DKFZp434B1272, GPR133, PGR25 ENSG00000111452 Adhesion G protein-coupled receptor D1 12 130953907-131141469 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA042395 Uncertain Approved Nucleus
Cytosol Liver cancer:9.27e-4 (unfavourable) Mixed Tissue enhanced placenta: 44.3 lung: 32.7 ADGRE1 EMR1, TM7LN3 ENSG00000174837 Adhesion G protein-coupled receptor E1 19 6887566-6940459 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at transcript level HPA052809 Uncertain Mixed Tissue enhanced appendix: 10.2;spleen: 20.1 lung: 6.8 ADGRE2 CD312, EMR2 ENSG00000127507 Adhesion G protein-coupled receptor E2 19 14732393-14778541 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA055200 Uncertain Vesicles Renal cancer:4.35e-6 (unfavourable) Mixed Tissue enhanced appendix: 27.6;spleen: 15.7 adipose tissue: 5.9 ADGRE3 EMR3 ENSG00000131355 Adhesion G protein-coupled receptor E3 19 14619117-14690027 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at transcript level HPA015638 Uncertain Not detected Tissue enhanced appendix: 8.9;spleen: 8.8 lung: 3.9 ADGRE5 CD97, TM7LN1 ENSG00000123146 Adhesion G protein-coupled receptor E5 19 14380501-14408725 CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA013707 Supported Approved Cytosol Renal cancer:1.87e-6 (unfavourable), Liver cancer:3.73e-5 (unfavourable) Expressed in all Expressed in all spleen: 142.8 ADGRF1 GPR110, hGPCR36, PGR19 ENSG00000153292 Adhesion G protein-coupled receptor F1 6 46997703-47042363 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA038438 Approved Renal cancer:1.35e-5 (favourable) Mixed Tissue enhanced esophagus: 14.7;kidney: 17.6;urinary bladder: 19.6 gallbladder: 9.5 ADGRF2 GPR111, hGPCR35, PGR20 ENSG00000164393 Adhesion G protein-coupled receptor F2 6 47656436-47697797 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA035507 Uncertain Not detected Tissue enhanced fallopian tube: 1.5;skin: 1.4 esophagus: 0.3 ADGRF3 GPR113, hGPCR37, PGR23 ENSG00000173567 Adhesion G protein-coupled receptor F3 2 26308173-26346817 G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA044500 Uncertain Not detected Not detected kidney: 0.9 ADGRF4 FLJ38076, GPR115, PGR18 ENSG00000153294 Adhesion G protein-coupled receptor F4 6 47685864-47722021 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA007131, HPA007158 Supported Uncertain Mitochondria Pancreatic cancer:5.52e-4 (unfavourable) Mixed Group enriched 7 esophagus: 12.1;skin: 45.9 tonsil: 3.9 ADGRG1 GPR56, TM7LN4, TM7XN1 ENSG00000205336 Adhesion G protein-coupled receptor G1 16 57610652-57665580 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA046065 Uncertain Renal cancer:5.52e-7 (favourable), Head and neck cancer:2.53e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 348.2 ADGRG3 GPR97, Pb99, PGR26 ENSG00000182885 Adhesion G protein-coupled receptor G3 16 57668187-57689378 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA040469 Uncertain Mixed Group enriched 5 appendix: 19.4;bone marrow: 86.7 adipose tissue: 9.6 ADGRG4 GPR112, PGR17, RP1-299I16 ENSG00000156920 Adhesion G protein-coupled receptor G4 X 136300963-136416888 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA035324 Uncertain Not detected Tissue enhanced duodenum: 2.6;small intestine: 1.7 fallopian tube: 0.5 ADGRG5 GPR114, PGR27 ENSG00000159618 Adhesion G protein-coupled receptor G5 16 57542421-57591681 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA007133 Supported Approved Nucleoplasm
Nuclear membrane
Vesicles Cervical cancer:4.25e-4 (favourable) Mixed Tissue enhanced lymph node: 11.3;tonsil: 8.9 appendix: 6.2 ADGRG6 FLJ14937, GPR126 ENSG00000112414 Adhesion G protein-coupled receptor G6 6 142301854-142446266 G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA017346 Approved Pancreatic cancer:2.78e-5 (unfavourable), Lung cancer:8.78e-4 (unfavourable) Mixed Tissue enhanced placenta: 66.6 liver: 36.9 ADGRL1 CIRL1, KIAA0821, LEC2, LPHN1 ENSG00000072071 Adhesion G protein-coupled receptor L1 19 14147743-14206187 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA037974 Uncertain Pancreatic cancer:1.14e-4 (favourable), Renal cancer:4.45e-4 (favourable) Expressed in all Tissue enhanced cerebral cortex: 60.3 parathyroid gland: 24.2 ADGRL2 KIAA0786, LEC1, LPHH1, LPHN2 ENSG00000117114 Adhesion G protein-coupled receptor L2 1 81306160-81992436 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA043447 Approved Plasma membrane
Cell Junctions Endometrial cancer:1.33e-4 (unfavourable), Stomach cancer:3.00e-4 (unfavourable), Liver cancer:9.92e-4 (unfavourable) Expressed in all Mixed thyroid gland: 72.8 ADGRL3 KIAA0768, LEC3, LPHN3 ENSG00000150471 Adhesion G protein-coupled receptor L3 4 61201258-62078335 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA015027, HPA015762, CAB022698 Uncertain Tissue enriched Tissue enhanced cerebral cortex: 42.1;parathyroid gland: 30.1 cervix, uterine: 8.5 ADGRL4 ELTD1, ETL ENSG00000162618 Adhesion G protein-coupled receptor L4 1 78889764-79006718 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA025229 Supported Renal cancer:1.60e-4 (unfavourable) Expressed in all Mixed adipose tissue: 67.6 ADGRV1 DKFZp761P0710, FEB4, GPR98, KIAA0686, MASS1, USH2C, VLGR1 ENSG00000164199 Adhesion G protein-coupled receptor V1 5 90529344-91164221 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA067503 Approved Mixed Group enriched 6 adrenal gland: 56.5;cerebral cortex: 29.1 thyroid gland: 6.6 ADIPOR2 ACDCR2, PAQR2 ENSG00000006831 Adiponectin receptor 2 12 1688574-1788678 Predicted membrane proteins Evidence at protein level HPA043737 Approved Expressed in all Expressed in all adipose tissue: 76.9 ADORA1 RDC7 ENSG00000163485 Adenosine A1 receptor 1 203090654-203167405 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA044383 Supported Plasma membrane Tissue enhanced Tissue enhanced cerebral cortex: 46.5;testis: 23.4 parathyroid gland: 17.5 ADORA2B ENSG00000170425 Adenosine A2b receptor 17 15944917-15975746 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA073747 Uncertain Cytosol Mixed Mixed colon: 8.3 ADRA1A ADRA1C, ADRA1L1 ENSG00000120907 Adrenoceptor alpha 1A 8 26748150-26867273 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA029678, HPA029679 Approved Tissue enhanced Tissue enhanced adipose tissue: 22.6;liver: 32.0 seminal vesicle: 19.5 ADRA1B ENSG00000170214 Adrenoceptor alpha 1B 5 159916783-159972544 Cancer-related genes, FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA074416 Supported Plasma membrane Renal cancer:1.40e-6 (unfavourable), Thyroid cancer:3.19e-5 (favourable), Endometrial cancer:6.00e-5 (unfavourable), Ovarian cancer:2.67e-4 (favourable), Glioma:6.07e-4 (unfavourable) Mixed Tissue enhanced cerebral cortex: 14.8;spleen: 17.3 ovary: 4.8 ADRA1D ADRA1, ADRA1A, ADRA1R ENSG00000171873 Adrenoceptor alpha 1D 20 4220631-4249074 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at transcript level HPA038789 Uncertain Mixed Tissue enhanced cervix, uterine: 4.3;prostate: 4.2 seminal vesicle: 2.5 ADRA2B ADRA2L1, ADRA2RL1, ADRARL1 ENSG00000274286 Adrenoceptor alpha 2B 2 96112875-96116245 Predicted membrane proteins Evidence at transcript level HPA066029 Approved Mixed Mixed epididymis: 5.0 ADRA2C ADRA2L2, ADRA2RL2, ADRARL2 ENSG00000184160 Adrenoceptor alpha 2C 4 3766348-3768526 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA057688 Uncertain Mixed Tissue enhanced cervix, uterine: 21.0;endometrium: 26.0;seminal vesicle: 26.7 fallopian tube: 7.9 ADRB1 ADRB1R ENSG00000043591 Adrenoceptor beta 1 10 114044056-114046908 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA067972 Supported Tissue enriched Tissue enhanced placenta: 45.2 heart muscle: 11.9 ADRB2 ADRB2R, ADRBR, B2AR, BAR ENSG00000169252 Adrenoceptor beta 2, surface 5 148825245-148828687 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA003431, HPA075322 Uncertain Uncertain Cytosol Renal cancer:3.15e-9 (favourable) Mixed Mixed lung: 16.3 AGTR1 AG2S, AGTR1A, AGTR1B, AT1, AT1B, AT2R1, AT2R1A, AT2R1B, HAT1R ENSG00000144891 Angiotensin II receptor, type 1 3 148697784-148743008 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA003596 Supported Uncertain Vesicles Group enriched Tissue enhanced placenta: 212.0 liver: 50.8 ALG8 MGC2840 ENSG00000159063 ALG8, alpha-1,3-glucosyltransferase 11 78100936-78139660 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA051898 Approved Approved Nucleoplasm Expressed in all Expressed in all testis: 85.6 AMFR gp78, RNF45 ENSG00000159461 Autocrine motility factor receptor, E3 ubiquitin protein ligase 16 56361452-56425538 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB026381, HPA029018, HPA077835 Approved Supported Endoplasmic reticulum
Golgi apparatus Expressed in all Expressed in all testis: 154.3 ANO10 FLJ10375, MGC47890, SCAR10, TMEM16K ENSG00000160746 Anoctamin 10 3 43354859-43691594 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA051569 Approved Renal cancer:6.41e-6 (favourable), Endometrial cancer:1.11e-4 (favourable), Liver cancer:3.19e-4 (unfavourable), Colorectal cancer:6.70e-4 (favourable) Expressed in all Expressed in all duodenum: 64.3 ANO4 FLJ34221, FLJ34272, FLJ35277, TMEM16D ENSG00000151572 Anoctamin 4 12 100717526-101128641 Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA053412 Uncertain Renal cancer:5.48e-5 (favourable) Mixed Group enriched 6 adrenal gland: 17.6;cerebral cortex: 10.0;cervix, uterine: 12.5;endometrium: 8.3;ovary: 10.9;prostate: 10.9;seminal vesicle: 11.3 testis: 2.0 APH1A APH-1A, CGI-78 ENSG00000117362 APH1A gamma secretase subunit 1 150265399-150269580 Predicted membrane proteins Evidence at protein level CAB037272 Approved Expressed in all Expressed in all thyroid gland: 160.6 APLF C2orf13, MGC47799, Xip1, ZCCHH1 ENSG00000169621 Aprataxin and PNKP like factor 2 68467561-68655862 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA029396, HPA034642, HPA034643 Approved Supported Nucleoplasm Mixed Mixed skin: 3.3 APLNR AGTRL1, APJ, APJR, FLJ90771 ENSG00000134817 Apelin receptor 11 57233577-57237314 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level CAB025842 Approved Expressed in all Group enriched 5 cerebral cortex: 82.9;placenta: 145.6;spleen: 164.2 adipose tissue: 24.9 AQP11 ENSG00000178301 Aquaporin 11 11 77589391-77610355 Predicted membrane proteins, Transporters Evidence at protein level HPA042879 Approved Approved Nucleoplasm
Vesicles Ovarian cancer:9.89e-4 (favourable) Mixed Tissue enhanced duodenum: 24.8;small intestine: 23.6 adrenal gland: 10.1 AQP2 ENSG00000167580 Aquaporin 2 (collecting duct) 12 49950741-49958881 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA046834 Supported Group enriched Group enriched 93 kidney: 432.9;seminal vesicle: 299.3 prostate: 3.9 AQP8 ENSG00000103375 Aquaporin 8 16 25215731-25228940 Predicted membrane proteins, Transporters Evidence at protein level HPA046259 Approved Group enriched Group enriched 132 colon: 325.1;pancreas: 269.4;rectum: 169.2 smooth muscle: 1.9 ATP6V0A1 a1, ATP6N1, ATP6N1A, Stv1, Vph1, VPP1 ENSG00000033627 ATPase, H+ transporting, lysosomal V0 subunit a1 17 42458844-42522611 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA022144 Supported Approved Nuclear speckles
Golgi apparatus
Vesicles
Cytosol Renal cancer:1.28e-4 (favourable), Pancreatic cancer:2.05e-4 (favourable), Urothelial cancer:6.90e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 201.5 ATP6V0A2 a2, ATP6a2, ATP6N1D, J6B7, Stv1, TJ6, TJ6M, TJ6s, Vph1 ENSG00000185344 ATPase, H+ transporting, lysosomal V0 subunit a2 12 123712318-123761755 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA044279 Approved Approved Plasma membrane
Cytosol Expressed in all Expressed in all skin: 15.2 ATP7B WND ENSG00000123191 ATPase, Cu++ transporting, beta polypeptide 13 51930436-52012125 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA009137, HPA013187 Supported Supported Golgi apparatus Endometrial cancer:5.01e-4 (unfavourable) Mixed Mixed testis: 14.0 AVPR2 DIR, DIR3, V2R ENSG00000126895 Arginine vasopressin receptor 2 X 153902531-153907166 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA046678 Approved Mixed Tissue enhanced adipose tissue: 5.8 heart muscle,kidney: 2.8 BDKRB1 B1BKR, BKR1, bradyb1 ENSG00000100739 Bradykinin receptor B1 14 96255824-96268967 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA002935 Approved Mixed Tissue enhanced gallbladder: 18.3;urinary bladder: 10.3 appendix: 7.0 BDKRB2 BK-2 ENSG00000168398 Bradykinin receptor B2 14 96204679-96244166 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA050841 Approved Mixed Mixed gallbladder: 32.6 C3AR1 AZ3B, C3AR ENSG00000171860 Complement component 3a receptor 1 12 8058302-8066471 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB009405 Supported Expressed in all Tissue enhanced appendix: 88.4 placenta: 49.2 C5AR1 C5A, C5AR, C5R1, CD88 ENSG00000197405 Complement component 5a receptor 1 19 47290023-47322066 CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB002720, HPA014520 Approved Renal cancer:1.16e-4 (unfavourable), Cervical cancer:4.71e-4 (favourable), Testis cancer:7.99e-4 (unfavourable), Ovarian cancer:9.55e-4 (unfavourable) Expressed in all Tissue enhanced appendix: 123.6 adipose tissue: 90.1 C5AR2 C5L2, GPR77 ENSG00000134830 Complement component 5a receptor 2 19 47332147-47347327 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA016629 Uncertain Tissue enhanced Tissue enhanced spleen: 9.9 appendix: 6.1 CALCR CTR ENSG00000004948 Calcitonin receptor 7 93424487-93574730 Predicted membrane proteins, Predicted secreted proteins Evidence at transcript level HPA028962 Uncertain Tissue enriched Tissue enhanced kidney: 2.1;testis: 1.4 placenta: 0.9 CALCRL CGRPR, CRLR ENSG00000064989 Calcitonin receptor-like 2 187343129-187448460 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA008070, HPA046515 Uncertain Supported Plasma membrane Expressed in all Tissue enhanced lung: 114.4 adipose tissue: 76.3 CASR FHH, GPRC2A, HHC, HHC1, NSHPT ENSG00000036828 Calcium-sensing receptor 3 122183683-122286503 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA039686, HPA050335 Supported Tissue enriched Tissue enriched 60 parathyroid gland: 1627.2 kidney: 27.0 CCR10 GPR2 ENSG00000184451 Chemokine (C-C motif) receptor 10 17 42678889-42683917 Cancer-related genes, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB011684, HPA048007, HPA069188 Uncertain Supported Endoplasmic reticulum Mixed Mixed adipose tissue: 4.5 CCR2 CC-CKR-2, CD192, CKR2, CMKBR2, FLJ78302, MCP-1-R ENSG00000121807 Chemokine (C-C motif) receptor 2 3 46353734-46360928 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB003793 Approved Lung cancer:5.87e-4 (favourable) Mixed Tissue enhanced appendix: 53.0 spleen: 20.8 CCR3 CC-CKR-3, CD193, CKR3, CMKBR3 ENSG00000183625 Chemokine (C-C motif) receptor 3 3 46163604-46266706 CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB003795 Uncertain Not detected Mixed small intestine: 3.0 CCR4 CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, k5-5 ENSG00000183813 Chemokine (C-C motif) receptor 4 3 32951574-32956349 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA031613 Approved Mixed Tissue enhanced appendix: 11.8 urinary bladder: 9.2 CCR6 BN-1, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22 ENSG00000112486 Chemokine (C-C motif) receptor 6 6 167111807-167139696 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB006820, HPA014488 Approved Not detected Tissue enhanced lymph node: 20.6;tonsil: 33.8 spleen: 17.3 CCR7 BLR2, CD197, CDw197, CMKBR7, EBI1 ENSG00000126353 Chemokine (C-C motif) receptor 7 17 40553769-40565472 Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB003796, HPA031383, HPA074467 Supported Supported Mitochondria Head and neck cancer:7.61e-7 (favourable), Cervical cancer:8.03e-6 (favourable), Breast cancer:3.84e-4 (favourable), Testis cancer:7.72e-4 (unfavourable) Mixed Group enriched 6 appendix: 91.9;lymph node: 98.3;spleen: 39.9;tonsil: 80.2 urinary bladder: 12.9 CCR9 CDw199, GPR-9-6, GPR28 ENSG00000173585 Chemokine (C-C motif) receptor 9 3 45886504-45903177 CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB006839 Uncertain Not detected Group enriched 6 appendix: 1.5;duodenum: 3.9;small intestine: 5.8;spleen: 1.2 lymph node: 0.5 CCRL2 ACKR5, CKRX, CRAM-A, CRAM-B, HCR ENSG00000121797 Chemokine (C-C motif) receptor-like 2 3 46407163-46412997 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA043238 Approved Colorectal cancer:3.72e-5 (favourable), Urothelial cancer:9.67e-5 (favourable) Mixed Mixed lung: 17.7 CDS2 ENSG00000101290 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 20 5126786-5197887 Enzymes, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA019698 Approved Approved Endoplasmic reticulum
Cytosol Renal cancer:3.53e-9 (favourable) Expressed in all Expressed in all cerebral cortex: 49.1 CELSR1 ADGRC1, CDHF9, FMI2, HFMI2, ME2 ENSG00000075275 Cadherin, EGF LAG seven-pass G-type receptor 1 22 46360834-46537170 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA052976, HPA060521, HPA067269 Uncertain Supported Plasma membrane Expressed in all Mixed fallopian tube: 15.4 CELSR2 ADGRC2, CDHF10, EGFL2, Flamingo1, KIAA0279, MEGF3 ENSG00000143126 Cadherin, EGF LAG seven-pass G-type receptor 2 1 109250019-109275750 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013952 Uncertain Approved Cytosol Expressed in all Tissue enhanced cerebral cortex: 45.2 skin: 31.1 CELSR3 ADGRC3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2 ENSG00000008300 Cadherin, EGF LAG seven-pass G-type receptor 3 3 48636469-48662915 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA062866 Approved Mixed Group enriched 6 adrenal gland: 1.6;cerebral cortex: 6.0;testis: 3.6 parathyroid gland,stomach: 0.6 CERS1 LAG1, LASS1, UOG1 ENSG00000223802 Ceramide synthase 1 19 18868545-18896727 Disease related genes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA045724 Approved Approved Endoplasmic reticulum Tissue enhanced Group enriched 13 cerebral cortex: 136.6;testis: 28.0 skeletal muscle: 6.5 CERS3 LASS3, MGC27091 ENSG00000154227 Ceramide synthase 3 15 100400395-100544995 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA006092, HPA024356 Uncertain Tissue enhanced Group enriched 9 esophagus: 48.3;skin: 60.7;testis: 32.1;tonsil: 14.9 breast: 4.2 CERS4 FLJ12089, LASS4, Trh1 ENSG00000090661 Ceramide synthase 4 19 8206736-8262421 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB033734, HPA054729 Uncertain Approved Nucleus
Vesicles Lung cancer:3.45e-5 (favourable), Renal cancer:9.63e-5 (favourable), Cervical cancer:2.71e-4 (favourable), Head and neck cancer:7.83e-4 (favourable), Pancreatic cancer:8.05e-4 (favourable) Expressed in all Mixed thyroid gland: 80.7 CERS5 FLJ25304, LASS5, MGC45411, Trh4 ENSG00000139624 Ceramide synthase 5 12 50129306-50167533 Enzymes, Predicted membrane proteins Evidence at protein level HPA026589 Approved Approved Nucleus
Nucleoli Renal cancer:9.33e-11 (unfavourable), Liver cancer:4.63e-5 (unfavourable), Thyroid cancer:5.76e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 37.9 CERS6 LASS6 ENSG00000172292 Ceramide synthase 6 2 168455862-168775137 Predicted membrane proteins Evidence at protein level HPA044683, HPA063527 Approved Supported Nucleus Liver cancer:1.10e-4 (unfavourable), Endometrial cancer:7.31e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 43.4 CHRM1 ENSG00000168539 Cholinergic receptor, muscarinic 1 11 62908679-62921807 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014101, CAB022366 Supported Approved Nucleus
Cytosol Tissue enriched Group enriched 6 cerebral cortex: 40.0;prostate: 40.1;salivary gland: 11.1 breast: 4.7 CHRM2 ENSG00000181072 Cholinergic receptor, muscarinic 2 7 136868669-137020255 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022338, HPA029795 Approved Tissue enhanced Tissue enhanced gallbladder: 18.4;heart muscle: 26.7;smooth muscle: 13.6 urinary bladder: 6.1 CHRM3 ENSG00000133019 Cholinergic receptor, muscarinic 3 1 239386565-239915452 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA024106, HPA048036 Approved Supported Plasma membrane Mixed Tissue enhanced cerebral cortex: 15.7 esophagus: 8.5 CHRM4 ENSG00000180720 Cholinergic receptor, muscarinic 4 11 46385098-46386608 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022444, HPA072083 Uncertain Uncertain Nucleus
Golgi apparatus Mixed Tissue enhanced cerebral cortex: 8.1;small intestine: 7.9;spleen: 21.9 testis: 6.9 CHRM5 ENSG00000184984 Cholinergic receptor, muscarinic 5 15 33968720-34067457 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA013172 Uncertain Not detected Tissue enhanced cerebral cortex: 3.1;testis: 4.1 placenta: 2.5 CLCNKB hClC-Kb ENSG00000184908 Chloride channel, voltage-sensitive Kb 1 16043736-16057308 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA057717 Approved Renal cancer:1.27e-7 (favourable) Tissue enriched Tissue enhanced kidney: 107.5 salivary gland: 22.1 CLN3 BTS, JNCL ENSG00000188603 Ceroid-lipofuscinosis, neuronal 3 16 28477279-28495575 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA063280 Uncertain Expressed in all Expressed in all placenta: 54.9 CMKLR1 RVER1 ENSG00000174600 Chemerin chemokine-like receptor 1 12 108288044-108339341 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA047865 Uncertain Expressed in all Tissue enhanced spleen: 49.3 placenta: 40.0 CNR1 CANN6, CB-R, CB1, CB1A, CB1K5, CNR ENSG00000118432 Cannabinoid receptor 1 (brain) 6 88139864-88166359 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB005603, HPA042256 Approved Approved Plasma membrane
Actin filaments Tissue enriched Tissue enhanced cerebral cortex: 32.2 adipose tissue: 12.1 CNR2 CB2 ENSG00000188822 Cannabinoid receptor 2 (macrophage) 1 23870526-23913362 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB009719 Uncertain Tissue enriched Group enriched 7 appendix: 3.2;lymph node: 8.8;spleen: 8.1;tonsil: 7.2 bone marrow: 1.0 COQ2 CL640, FLJ26072 ENSG00000173085 Coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 4 83261536-83284914 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA056599, HPA068727 Approved Approved Cytosol Expressed in all Expressed in all adrenal gland: 18.5 COX15 CEMCOX2 ENSG00000014919 Cytochrome c oxidase assembly homolog 15 (yeast) 10 99711844-99732100 Disease related genes, Predicted membrane proteins Evidence at protein level HPA037727, HPA037728, HPA066096 Uncertain Supported Mitochondria Renal cancer:9.21e-6 (favourable) Expressed in all Expressed in all thyroid gland: 36.2 CRHR2 CRF-RB, CRF2, HM-CRF ENSG00000106113 Corticotropin releasing hormone receptor 2 7 30651943-30700129 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA046683 Uncertain Not detected Tissue enhanced seminal vesicle: 1.8 cerebral cortex: 1.2 CX3CR1 CCRL1, CMKBRL1, CMKDR1, GPR13, V28 ENSG00000168329 Chemokine (C-X3-C motif) receptor 1 3 39263494-39281735 Disease related genes, G-protein coupled receptors, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level CAB032478, HPA046587 Approved Tissue enhanced Tissue enhanced cerebral cortex: 59.4 spleen: 16.8 CXCR1 CD181, CDw128a, CKR-1, CMKAR1, IL8RA ENSG00000163464 Chemokine (C-X-C motif) receptor 1 2 218162845-218166995 Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA031991 Uncertain Mixed Tissue enhanced appendix: 35.7;spleen: 25.4 adipose tissue: 15.5 CXCR2 CD182, CMKAR2, IL8RB ENSG00000180871 Chemokine (C-X-C motif) receptor 2 2 218125289-218137253 Cancer-related genes, CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB016268, HPA031999, HPA032017 Supported Mixed Tissue enhanced appendix: 56.9;spleen: 37.2 esophagus: 30.0 CXCR3 CD183, CKR-L2, CMKAR3, GPR9, IP10-R, MigR ENSG00000186810 Chemokine (C-X-C motif) receptor 3 X 71615916-71618517 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA045942 Supported Renal cancer:1.67e-6 (unfavourable), Endometrial cancer:3.44e-6 (favourable), Melanoma:2.90e-4 (favourable), Head and neck cancer:3.35e-4 (favourable) Mixed Tissue enhanced lymph node: 18.1 spleen: 8.9 CXCR5 BLR1, CD185, MDR15 ENSG00000160683 Chemokine (C-X-C motif) receptor 5 11 118883766-118897799 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB026149, HPA042432 Supported Not detected Tissue enhanced lymph node: 32.9;spleen: 21.7;tonsil: 16.2 appendix: 15.1 CXCR6 BONZO, CD186, STRL33, TYMSTR ENSG00000172215 Chemokine (C-X-C motif) receptor 6 3 45940933-45948353 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA047591 Uncertain Endometrial cancer:6.74e-6 (favourable), Renal cancer:2.42e-5 (unfavourable), Head and neck cancer:2.16e-4 (favourable), Cervical cancer:4.92e-4 (favourable) Mixed Mixed lymph node: 17.6 CYBB CGD, GP91-PHOX, NOX2 ENSG00000165168 Cytochrome b-245, beta polypeptide X 37780011-37813461 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA051227 Supported Expressed in all Tissue enhanced appendix: 221.1 lung: 132.4 CYSLTR1 CysLT(1), CysLT1, CYSLT1R ENSG00000173198 Cysteinyl leukotriene receptor 1 X 78271464-78327691 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA010546 Approved Mixed Mixed spleen: 15.1 CYSLTR2 CysLT(2), CYSLT2R ENSG00000152207 Cysteinyl leukotriene receptor 2 13 48653711-48711226 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA046528 Uncertain Group enriched Tissue enhanced placenta: 36.4;seminal vesicle: 24.8 spleen: 11.6 DCST1 FLJ32785 ENSG00000163357 DC-STAMP domain containing 1 1 155033824-155050930 Predicted membrane proteins Evidence at protein level HPA060314 Uncertain Not detected Group enriched 5 skin: 3.7;testis: 6.2 small intestine: 0.9 DRD1 ENSG00000184845 Dopamine receptor D1 5 175440039-175444208 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013393 Uncertain Mixed Tissue enhanced cerebral cortex: 8.0 prostate: 1.6 DRD2 ENSG00000149295 Dopamine receptor D2 11 113409615-113475691 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA015691 Supported Mixed Tissue enriched 5 adrenal gland: 11.3 smooth muscle: 2.2 DRD5 DRD1B, DRD1L2 ENSG00000169676 Dopamine receptor D5 4 9781680-9784009 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA048930 Supported Not detected Tissue enhanced appendix: 1.8;cerebral cortex: 2.0;stomach: 3.7 testis: 0.8 DUOX1 LNOX1, NOXEF1, THOX1 ENSG00000137857 Dual oxidase 1 15 45129933-45165576 Enzymes, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA023544 Approved Cervical cancer:4.31e-6 (favourable) Tissue enhanced Tissue enhanced skin: 96.8;thyroid gland: 92.3 esophagus: 73.4 EDNRA ENSG00000151617 Endothelin receptor type A 4 147480917-147544954 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013774, CAB018957 Uncertain Renal cancer:1.50e-7 (unfavourable), Stomach cancer:3.93e-4 (unfavourable) Expressed in all Tissue enhanced seminal vesicle: 145.4 cervix, uterine: 82.6 EDNRB ETB, HSCR, HSCR2 ENSG00000136160 Endothelin receptor type B 13 77895481-77919768 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB017842, HPA027546 Approved Approved Plasma membrane
Cytosol Renal cancer:7.20e-5 (favourable) Group enriched Tissue enhanced placenta: 178.8 cerebral cortex: 89.1 ELOVL1 Ssc1 ENSG00000066322 ELOVL fatty acid elongase 1 1 43363397-43368074 Enzymes, Predicted membrane proteins Evidence at protein level CAB033426, HPA056557 Approved Approved Endoplasmic reticulum Liver cancer:2.79e-7 (unfavourable), Cervical cancer:3.63e-5 (unfavourable), Pancreatic cancer:8.51e-4 (unfavourable) Expressed in all Expressed in all skin: 157.0 ELOVL3 CIG-30 ENSG00000119915 ELOVL fatty acid elongase 3 10 102226328-102229589 Enzymes, Predicted membrane proteins Evidence at protein level HPA036236 Supported Approved Vesicles
Cytosol Endometrial cancer:6.25e-5 (unfavourable) Tissue enhanced Tissue enhanced adipose tissue: 3.6;breast: 4.4;skin: 3.4 testis: 2.3 ELOVL5 dJ483K16.1, HELO1, SCA38 ENSG00000012660 ELOVL fatty acid elongase 5 6 53267398-53349179 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB017042, HPA047752, HPA054197 Supported Validated Endoplasmic reticulum Renal cancer:1.94e-6 (unfavourable), Thyroid cancer:6.80e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 256.1 ELOVL6 FLJ23378, LCE, MGC5487 ENSG00000170522 ELOVL fatty acid elongase 6 4 110045846-110199199 Enzymes, Predicted membrane proteins Evidence at protein level HPA042355 Uncertain Colorectal cancer:6.74e-4 (favourable) Expressed in all Mixed liver: 27.9 ELOVL7 FLJ23563 ENSG00000164181 ELOVL fatty acid elongase 7 5 60751791-60844389 Enzymes, Predicted membrane proteins Evidence at protein level HPA036337 Approved Renal cancer:1.54e-9 (favourable), Endometrial cancer:3.87e-5 (unfavourable) Expressed in all Mixed prostate: 36.3 F2R CF2R, PAR-1, PAR1, TR ENSG00000181104 Coagulation factor II (thrombin) receptor 5 76716043-76735781 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB008973, CAB012962 Approved Renal cancer:2.21e-7 (unfavourable) Expressed in all Expressed in all spleen: 95.4 F2RL1 GPR11, PAR2 ENSG00000164251 Coagulation factor II (thrombin) receptor-like 1 5 76818933-76835315 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level CAB012989, HPA014091 Approved Approved Plasma membrane Renal cancer:5.86e-7 (favourable), Colorectal cancer:3.88e-4 (favourable), Head and neck cancer:5.88e-4 (unfavourable), Lung cancer:8.92e-4 (unfavourable) Expressed in all Mixed colon: 59.9 FAIM2 KIAA0950, LFG, LFG2, LIFEGUARD, NMP35, TMBIM2 ENSG00000135472 Fas apoptotic inhibitory molecule 2 12 49866896-49904217 Predicted membrane proteins Evidence at protein level HPA018790, HPA048800 Supported Approved Intermediate filaments Tissue enriched Tissue enriched 7 cerebral cortex: 370.8 adrenal gland: 56.0 FFAR2 FFA2R, GPR43 ENSG00000126262 Free fatty acid receptor 2 19 35443907-35451767 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA023985 Approved Tissue enhanced Tissue enhanced appendix: 26.2;bone marrow: 13.4 spleen: 11.1 FFAR3 FFA3R, GPR41 ENSG00000185897 Free fatty acid receptor 3 19 35358460-35360485 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA044681 Uncertain Not detected Tissue enhanced adipose tissue: 2.5;appendix: 3.6;smooth muscle: 2.2 gallbladder: 0.8 FFAR4 GPR120, GPR129, O3FAR1, PGR4 ENSG00000186188 Free fatty acid receptor 4 10 93566665-93604480 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA042563 Uncertain Uncertain Plasma membrane Tissue enhanced Tissue enhanced colon: 8.6;rectum: 12.9 lung: 5.5 FLVCR1 AXPC1, FLVCR, MFSD7B, PCA ENSG00000162769 Feline leukemia virus subgroup C cellular receptor 1 1 212858255-212899363 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA046646 Approved Approved Cell Junctions Renal cancer:1.06e-5 (unfavourable), Liver cancer:2.52e-5 (unfavourable), Pancreatic cancer:3.50e-4 (favourable) Expressed in all Tissue enhanced small intestine: 21.9 duodenum: 10.0 FLVCR2 C14orf58, FLJ20371, MFSD7C ENSG00000119686 Feline leukemia virus subgroup C cellular receptor family, member 2 14 75578617-75663214 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA037984 Supported Renal cancer:2.53e-5 (favourable) Expressed in all Tissue enhanced testis: 38.5 small intestine: 27.4 FPR1 FMLP, FPR ENSG00000171051 Formyl peptide receptor 1 19 51745172-51804110 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA046550, HPA061744 Approved Approved Nucleus
Nucleoli
Golgi apparatus Renal cancer:2.21e-4 (unfavourable) Expressed in all Tissue enhanced appendix: 181.6 bone marrow: 95.2 FPR2 ALXR, FMLP-R-II, FMLPX, FPR2A, FPRH2, FPRL1, HM63, LXA4R ENSG00000171049 Formyl peptide receptor 2 19 51752026-51770526 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA029154 Approved Mixed Tissue enhanced appendix: 71.3 spleen: 20.0 FZD10 CD350 ENSG00000111432 Frizzled class receptor 10 12 130162459-130165740 CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA014484, HPA014485 Uncertain Supported Nucleoplasm Endometrial cancer:5.05e-7 (favourable) Mixed Tissue enhanced cervix, uterine: 9.3;esophagus: 8.8 skin: 5.6 FZD2 ENSG00000180340 Frizzled class receptor 2 17 44557459-44559570 Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA057667 Uncertain Approved Nuclear bodies
Cell Junctions Expressed in all Mixed placenta: 4.9 FZD3 ENSG00000104290 Frizzled class receptor 3 8 28494205-28574268 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB024995, HPA042320 Approved Approved Nucleoplasm
Vesicles Colorectal cancer:1.17e-4 (favourable), Ovarian cancer:3.71e-4 (favourable) Mixed Mixed cerebral cortex: 16.5 FZD4 CD344, EVR1 ENSG00000174804 Frizzled class receptor 4 11 86945679-86955391 CD markers, Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA042328, HPA074833 Approved Approved Nucleoplasm
Plasma membrane
Cytosol Renal cancer:8.60e-5 (favourable) Expressed in all Tissue enhanced adipose tissue: 127.0 seminal vesicle: 42.1 FZD5 C2orf31, DKFZP434E2135, HFZ5 ENSG00000163251 Frizzled class receptor 5 2 207762586-207769563 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA052361 Approved Expressed in all Mixed duodenum: 20.1 FZD6 Hfz6 ENSG00000164930 Frizzled class receptor 6 8 103298433-103332866 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA017991 Approved Approved Plasma membrane Pancreatic cancer:1.20e-6 (unfavourable) Expressed in all Mixed parathyroid gland: 45.3 FZD7 FzE3 ENSG00000155760 Frizzled class receptor 7 2 202034587-202038445 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA069165 Approved Nucleoplasm Liver cancer:7.71e-5 (unfavourable) Expressed in all Mixed seminal vesicle: 38.7 FZD8 ENSG00000177283 Frizzled class receptor 8 10 35638249-35642278 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA045025, HPA071142 Approved Approved Endoplasmic reticulum Pancreatic cancer:8.21e-4 (favourable) Expressed in all Tissue enhanced spleen: 16.2 lung: 6.6 GABBR1 GPRC3A, hGB1a ENSG00000204681 Gamma-aminobutyric acid (GABA) B receptor, 1 6 29555629-29633976 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA050483, HPA058459 Uncertain Uncertain Centrosome Renal cancer:3.77e-10 (unfavourable), Pancreatic cancer:2.54e-5 (favourable) Expressed in all Tissue enhanced cerebral cortex: 20.9 spleen: 13.3 GABBR2 GABABR2, GPR51, GPRC3B, HG20 ENSG00000136928 Gamma-aminobutyric acid (GABA) B receptor, 2 9 98288082-98709197 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA013820, HPA031684 Supported Group enriched Tissue enriched 19 cerebral cortex: 88.4 adrenal gland: 4.6 GALR2 GALNR2 ENSG00000182687 Galanin receptor 2 17 76074794-76077541 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA044513 Approved Mixed Tissue enhanced smooth muscle: 2.4 bone marrow: 0.6 GCGR GGR ENSG00000215644 Glucagon receptor 17 81804132-81814013 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA071228 Approved Golgi apparatus Tissue enhanced Group enriched 7 adrenal gland: 6.6;kidney: 8.5;liver: 20.9;parathyroid gland: 9.4 skin: 1.6 GGCX VKCFD1 ENSG00000115486 Gamma-glutamyl carboxylase 2 85544723-85561547 Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level HPA018284 Approved Endometrial cancer:1.82e-6 (unfavourable) Expressed in all Expressed in all liver: 61.2 GHSR ENSG00000121853 Growth hormone secretagogue receptor 3 172445133-172448456 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB012451 Uncertain Not detected Not detected adrenal gland: 0.3 GIPR ENSG00000010310 Gastric inhibitory polypeptide receptor 19 45668244-45683724 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB022710 Uncertain Tissue enriched Tissue enhanced stomach: 22.6 parathyroid gland: 12.2 GLP2R ENSG00000065325 Glucagon-like peptide 2 receptor 17 9822206-9892102 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022690, HPA049244 Supported Supported Plasma membrane Tissue enhanced Tissue enhanced gallbladder: 19.4 duodenum: 10.4 GNRHR GRHR, LHRHR ENSG00000109163 Gonadotropin-releasing hormone receptor 4 67739328-67754360 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA013424 Supported Not detected Tissue enhanced parathyroid gland: 1.2 adrenal gland: 1.0 GPBAR1 BG37, GPCR, GPCR19, GPR131, M-BAR, MGC40597, TGR5 ENSG00000179921 G protein-coupled bile acid receptor 1 2 218259496-218263859 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA062890 Approved Tissue enhanced Tissue enhanced gallbladder: 27.0;smooth muscle: 13.8 adipose tissue: 10.0 GPER1 CEPR, CMKRL2, DRY12, FEG-1, GPCR-Br, GPER, GPR30, LERGU, LERGU2, LyGPR ENSG00000164850 G protein-coupled estrogen receptor 1 7 1082208-1093815 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA027052 Approved Endometrial cancer:1.17e-4 (favourable) Expressed in all Mixed placenta: 9.1 GPR1 ENSG00000183671 G protein-coupled receptor 1 2 206175316-206218047 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010525 Uncertain Supported Vesicles
Plasma membrane Mixed Tissue enhanced placenta: 11.2 esophagus: 5.5 GPR101 ENSG00000165370 G protein-coupled receptor 101 X 137030148-137031674 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA001084 Uncertain Not detected Not detected cerebral cortex: 0.1 GPR107 FLJ20998, KIAA1624, LUSTR1, RP11-88G17 ENSG00000148358 G protein-coupled receptor 107 9 130053426-130140169 Predicted membrane proteins Evidence at protein level HPA031704 Supported Approved Nucleoplasm
Golgi apparatus Renal cancer:1.87e-5 (favourable), Breast cancer:3.56e-5 (unfavourable) Expressed in all Expressed in all thyroid gland: 55.1 GPR12 GPCR21, PPP1R84 ENSG00000132975 G protein-coupled receptor 12 13 26755200-26760785 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA050972 Uncertain Group enriched Tissue enhanced cerebral cortex: 8.0 breast: 1.7 GPR132 G2A ENSG00000183484 G protein-coupled receptor 132 14 105049389-105065445 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA029694, HPA029695 Supported Renal cancer:1.71e-5 (unfavourable), Cervical cancer:3.21e-4 (favourable), Head and neck cancer:6.44e-4 (favourable) Mixed Mixed appendix: 9.7 GPR135 HUMNPIIY20, PAFR ENSG00000181619 G protein-coupled receptor 135 14 59429022-59465342 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA045337 Uncertain Mixed Tissue enhanced testis: 9.1 fallopian tube: 5.0 GPR137 C11orf4, GPR137A, TM7SF1L1 ENSG00000173264 G protein-coupled receptor 137 11 64270062-64289500 Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA062871 Uncertain Approved Nucleus
Nucleoli
Actin filaments Liver cancer:5.34e-4 (unfavourable), Pancreatic cancer:6.18e-4 (favourable) Expressed in all Expressed in all testis: 147.8 GPR137B TM7SF1 ENSG00000077585 G protein-coupled receptor 137B 1 236142505-236221865 Predicted membrane proteins, Transporters Evidence at protein level HPA026422 Approved Colorectal cancer:1.63e-4 (unfavourable) Expressed in all Mixed kidney: 70.2 GPR137C DKFZp762F0713, TM7SF1L2 ENSG00000180998 G protein-coupled receptor 137C 14 52553148-52637713 Predicted membrane proteins Evidence at transcript level HPA003640, HPA030763 Uncertain Approved Vesicles Mixed Tissue enhanced cerebral cortex: 18.0;epididymis: 10.5 testis: 8.2 GPR139 PGR3 ENSG00000180269 G protein-coupled receptor 139 16 20031485-20073917 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA046596 Uncertain Not detected Not detected endometrium: 0.3 GPR142 PGR2 ENSG00000257008 G protein-coupled receptor 142 17 74367407-74372622 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA031392 Uncertain Uncertain Plasma membrane
Cell Junctions
Cytosol Tissue enhanced Not detected appendix: 0.1 GPR143 OA1 ENSG00000101850 G protein-coupled receptor 143 X 9725346-9786297 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA003648 Approved Renal cancer:2.45e-5 (favourable), Cervical cancer:8.73e-4 (favourable) Tissue enriched Mixed skin: 10.3 GPR148 PGR6 ENSG00000173302 G protein-coupled receptor 148 2 130729070-130730336 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA060527 Uncertain Not detected Not detected stomach: 0.4 GPR15 ENSG00000154165 G protein-coupled receptor 15 3 98531899-98533150 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA013775 Approved Mixed Tissue enhanced colon: 25.7;rectum: 47.8 urinary bladder: 19.1 GPR150 PGR11 ENSG00000178015 G protein-coupled receptor 150 5 95620078-95622142 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA026635 Uncertain Mixed Tissue enhanced cerebral cortex: 1.3;parathyroid gland: 2.0 pancreas: 1.0 GPR152 PGR5 ENSG00000175514 G protein-coupled receptor 152 11 67451301-67452729 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA035078 Uncertain Not detected Not detected parathyroid gland: 0.2 GPR156 GABABL, PGR28 ENSG00000175697 G protein-coupled receptor 156 3 120164645-120285094 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028642, HPA028644 Uncertain Supported Plasma membrane Mixed Tissue enhanced testis: 5.1 fallopian tube: 1.8 GPR158 KIAA1136 ENSG00000151025 G protein-coupled receptor 158 10 25175062-25602226 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013185 Uncertain Approved Cytosol Mixed Tissue enriched 17 cerebral cortex: 17.9 testis: 1.0 GPR160 GPCR1, GPCR150 ENSG00000173890 G protein-coupled receptor 160 3 170037929-170085403 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA006970 Approved Supported Plasma membrane Renal cancer:4.93e-7 (favourable), Lung cancer:1.21e-4 (favourable), Urothelial cancer:3.61e-4 (favourable) Expressed in all Tissue enhanced parathyroid gland: 426.5 small intestine: 111.2 GPR161 RE2 ENSG00000143147 G protein-coupled receptor 161 1 168079543-168137667 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at transcript level HPA015576, HPA072047 Uncertain Approved Nucleus
Nucleoli Mixed Tissue enhanced smooth muscle: 39.8 endometrium: 28.5 GPR162 A-2, GRCA ENSG00000250510 G protein-coupled receptor 162 12 6821545-6829972 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA055135 Supported Approved Microtubule organizing center Renal cancer:1.37e-6 (unfavourable), Pancreatic cancer:4.29e-5 (favourable) Tissue enriched Group enriched 6 cerebral cortex: 84.5;fallopian tube: 29.1 lung: 9.6 GPR17 ENSG00000144230 G protein-coupled receptor 17 2 127645864-127652639 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA029766 Approved Approved Vesicles Tissue enriched Mixed spleen: 12.3 GPR171 H963 ENSG00000174946 G protein-coupled receptor 171 3 151197832-151203201 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA062429 Approved Mixed Tissue enhanced appendix: 30.7 lymph node: 21.8 GPR173 SREB3 ENSG00000184194 G protein-coupled receptor 173 X 53049091-53080615 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA003905 Approved Plasma membrane
Cytosol Endometrial cancer:2.88e-6 (unfavourable), Pancreatic cancer:2.33e-5 (favourable), Renal cancer:2.47e-4 (unfavourable) Tissue enhanced Tissue enhanced cerebral cortex: 19.1 ovary: 9.0 GPR174 FKSG79 ENSG00000147138 G protein-coupled receptor 174 X 79170972-79172229 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA041025 Supported Uncertain Vesicles Mixed Tissue enhanced lymph node: 30.2;spleen: 16.9;tonsil: 17.8 appendix: 13.1 GPR176 Gm1012 ENSG00000166073 G protein-coupled receptor 176 15 39799023-39920892 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA039943, HPA039979 Approved Renal cancer:9.38e-7 (unfavourable), Stomach cancer:6.84e-5 (unfavourable) Expressed in all Mixed cerebral cortex: 19.1 GPR179 CSNB1E, GPR158L1 ENSG00000277399 G protein-coupled receptor 179 17 38325530-38343847 Predicted membrane proteins No evidence HPA017885 Uncertain Not detected Not detected epididymis: 0.1 GPR18 ENSG00000125245 G protein-coupled receptor 18 13 99254714-99261744 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013873 Supported Mixed Tissue enhanced lymph node: 52.2;testis: 25.1;tonsil: 32.9 appendix: 17.0 GPR180 ITR ENSG00000152749 G protein-coupled receptor 180 13 94601903-94634645 Predicted membrane proteins Evidence at protein level HPA047250 Approved Approved Vesicles Renal cancer:3.18e-5 (unfavourable) Expressed in all Mixed adipose tissue: 6.3 GPR182 ADMR, AM-R, G10D, hrhAMR ENSG00000166856 G protein-coupled receptor 182 12 56994446-56998441 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA027037 Supported Not detected Tissue enhanced spleen: 12.4;testis: 6.6 liver: 2.0 GPR183 EBI2 ENSG00000169508 G protein-coupled receptor 183 13 99294530-99307405 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028847, CAB033690 Uncertain Approved Nuclear membrane
Vesicles Cervical cancer:9.77e-4 (favourable) Expressed in all Mixed appendix: 117.8 GPR19 ENSG00000183150 G protein-coupled receptor 19 12 12660891-12696207 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA013955 Uncertain Tissue enhanced Tissue enhanced cerebral cortex: 8.5;testis: 7.7 appendix: 2.8 GPR21 ENSG00000188394 G protein-coupled receptor 21 9 123034527-123035696 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA041651 Uncertain Not detected Tissue enhanced cerebral cortex: 2.1 endometrium: 0.9 GPR27 SREB1 ENSG00000170837 G protein-coupled receptor 27 3 71754050-71756496 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA029395 Approved Approved Nucleoplasm
Plasma membrane
Actin filaments
Cytosol Ovarian cancer:1.21e-6 (favourable), Breast cancer:5.63e-4 (favourable) Mixed Tissue enhanced parathyroid gland: 45.7 cerebral cortex: 24.9 GPR3 ACCA ENSG00000181773 G protein-coupled receptor 3 1 27392644-27395814 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB006254 Uncertain Mixed Tissue enhanced cerebral cortex: 5.3 thyroid gland: 1.3 GPR32 RVDR1 ENSG00000142511 G protein-coupled receptor 32 19 50770464-50771732 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA030330 Approved Not detected Tissue enriched 98 parathyroid gland: 254.8 placenta: 2.5 GPR34 ENSG00000171659 G protein-coupled receptor 34 X 41688973-41697277 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA010668, CAB025490 Uncertain Uncertain Nucleus
Cytosol Expressed in all Mixed placenta: 60.4 GPR37 EDNRBL, hET(B)R-LP, PAELR ENSG00000170775 G protein-coupled receptor 37 (endothelin receptor type B-like) 7 124745997-124765627 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA042903, HPA068009 Approved Approved Nuclear membrane
Cytosol Lung cancer:6.00e-5 (unfavourable), Ovarian cancer:7.26e-4 (favourable) Tissue enhanced Tissue enhanced cerebral cortex: 78.9;testis: 27.6 placenta: 12.7 GPR39 ENSG00000183840 G protein-coupled receptor 39 2 132416574-132646559 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA022111 Approved Pancreatic cancer:7.50e-4 (unfavourable) Mixed Tissue enhanced parathyroid gland: 17.7 colon: 6.2 GPR4 ENSG00000177464 G protein-coupled receptor 4 19 45589764-45602208 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014278 Uncertain Renal cancer:2.07e-5 (unfavourable), Lung cancer:9.19e-4 (unfavourable) Expressed in all Mixed adipose tissue: 10.3 GPR42 FFAR3L, GPR41L, GPR42P ENSG00000126251 G protein-coupled receptor 42 (gene/pseudogene) 19 35370929-35372962 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA044681 Uncertain Not detected Not detected appendix,small intestine: 0.3 GPR45 PSP24, PSP24A ENSG00000135973 G protein-coupled receptor 45 2 105241743-105243049 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA055940 Uncertain Not detected Tissue enhanced cerebral cortex: 1.8 testis: 0.5 GPR50 H9, Mel1c ENSG00000102195 G protein-coupled receptor 50 X 151176653-151181465 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA049862, HPA054678 Supported Supported Nucleoplasm
Plasma membrane Mixed Not detected placenta: 0.6 GPR52 ENSG00000203737 G protein-coupled receptor 52 1 174448111-174449198 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA028575 Uncertain Not detected Tissue enriched 7 cerebral cortex: 2.7 bone marrow: 0.3 GPR61 BALGR ENSG00000156097 G protein-coupled receptor 61 1 109539872-109548406 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA007326, HPA026088 Approved Not detected Tissue enhanced cerebral cortex: 3.4;thyroid gland: 1.2 adrenal gland: 1.0 GPR63 PSP24(beta), PSP24B ENSG00000112218 G protein-coupled receptor 63 6 96794126-96837463 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA039103 Approved Approved Nucleus
Plasma membrane
Cytosol Mixed Mixed testis: 4.6 GPR65 hTDAG8, TDAG8 ENSG00000140030 G protein-coupled receptor 65 14 88005124-88014811 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA054454 Approved Cytosol Renal cancer:4.99e-4 (unfavourable) Mixed Mixed spleen: 13.5 GPR82 ENSG00000171657 G protein-coupled receptor 82 X 41724155-41730135 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA035914 Approved Mixed Tissue enhanced tonsil: 6.7 lymph node: 3.7 GPR84 EX33 ENSG00000139572 G protein-coupled receptor 84 12 54362445-54364487 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA027603 Supported Mixed Tissue enhanced appendix: 11.9;bone marrow: 14.7 adipose tissue: 5.9 GPR87 GPR95 ENSG00000138271 G protein-coupled receptor 87 3 151294086-151316952 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA066313 Approved Nucleoplasm
Lipid droplets
Mitochondria Pancreatic cancer:4.62e-6 (unfavourable) Group enriched Tissue enhanced esophagus: 29.4;skin: 29.8 placenta: 11.9 GPR88 ENSG00000181656 G protein-coupled receptor 88 1 100538137-100542018 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA007488 Uncertain Approved Tissue enriched Group enriched 12 breast: 9.7;cerebral cortex: 3.1;liver: 5.1;ovary: 3.4;parathyroid gland: 7.9;spleen: 14.7 adipose tissue,prostate: 0.6 GPRC5A PEIG-1, RAI3, RAIG1, TIG1 ENSG00000013588 G protein-coupled receptor, class C, group 5, member A 12 12890782-12917937 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA007928, HPA046526 Approved Validated Vesicles
Plasma membrane Pancreatic cancer:4.63e-6 (unfavourable), Renal cancer:9.02e-5 (unfavourable) Mixed Tissue enhanced lung: 302.3 thyroid gland: 90.7 GPRC5B RAIG-2 ENSG00000167191 G protein-coupled receptor, class C, group 5, member B 16 19856691-19886167 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA015247 Approved Supported Nucleus
Nucleoli
Vesicles Colorectal cancer:9.27e-5 (unfavourable), Renal cancer:6.30e-4 (favourable) Expressed in all Tissue enhanced cerebral cortex: 309.2 testis: 66.5 GPRC5C RAIG-3 ENSG00000170412 G protein-coupled receptor, class C, group 5, member C 17 74424851-74451653 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA029776 Supported Uncertain Nucleus
Microtubule organizing center
Cytosol Renal cancer:1.58e-5 (favourable) Expressed in all Mixed thyroid gland: 103.7 GPRC5D ENSG00000111291 G protein-coupled receptor, class C, group 5, member D 12 12940775-12952147 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA071909 Approved Head and neck cancer:5.09e-4 (favourable) Mixed Mixed testis: 5.2 GRINA HNRGW, LFG1, NMDARA1, TMBIM3 ENSG00000178719 Glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) 8 143990058-143993415 Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA036980, HPA036981 Approved Approved Nucleoli fibrillar center
Cytosol Expressed in all Expressed in all seminal vesicle: 261.5 GRM1 GPRC1A, mGlu1, MGLUR1, PPP1R85 ENSG00000152822 Glutamate receptor, metabotropic 1 6 146027646-146437598 Disease related genes, G-protein coupled receptors, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA015701 Approved Approved Vesicles Not detected Tissue enhanced cerebral cortex: 7.1 heart muscle: 1.4 GRM2 GPRC1B, mGlu2, MGLUR2 ENSG00000164082 Glutamate receptor, metabotropic 2 3 51707070-51718613 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA065166 Approved Tissue enhanced Tissue enriched 10 cerebral cortex: 4.4 testis: 0.4 GRM4 GPRC1D, mGlu4, MGLUR4 ENSG00000124493 Glutamate receptor, metabotropic 4 6 34018645-34155622 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB022096 Supported Tissue enhanced Tissue enhanced cerebral cortex: 2.9 testis: 0.7 GRM6 CSNB1B, GPRC1F, mGlu6, MGLUR6 ENSG00000113262 Glutamate receptor, metabotropic 6 5 178978327-178996206 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA014511 Supported Not detected Not detected testis: 0.8 GRM7 GLUR7, GPRC1G, mGlu7, MGLUR7, PPP1R87 ENSG00000196277 Glutamate receptor, metabotropic 7 3 6770001-7741533 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA015964 Uncertain Cytosol Not detected Tissue enhanced cerebral cortex: 10.1;parathyroid gland: 7.0 smooth muscle: 3.4 GRM8 GLUR8, GPRC1H, mGlu8, MGLUR8 ENSG00000179603 Glutamate receptor, metabotropic 8 7 126438598-127253294 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at transcript level HPA051481 Uncertain Tissue enhanced Tissue enhanced cerebral cortex: 4.1 testis: 2.9 GRPR BB2 ENSG00000126010 Gastrin-releasing peptide receptor X 16123556-16153021 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA069604 Validated Plasma membrane Tissue enhanced Tissue enhanced pancreas: 4.2 breast: 2.6 HAS1 HAS ENSG00000105509 Hyaluronan synthase 1 19 51713112-51723994 Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA067602 Approved Approved Nucleoplasm
Plasma membrane Mixed Tissue enhanced adipose tissue: 26.9 appendix: 9.1 HAS2 ENSG00000170961 Hyaluronan synthase 2 8 121612116-121641390 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA052060 Approved Nuclear speckles Mixed Tissue enhanced adipose tissue: 27.7 appendix: 12.9 HAS3 ENSG00000103044 Hyaluronan synthase 3 16 69105564-69118719 Enzymes, Predicted membrane proteins Evidence at protein level HPA031554, CAB033850 Supported Approved Microtubules Pancreatic cancer:5.36e-4 (unfavourable) Group enriched Tissue enhanced lung: 29.9;urinary bladder: 37.7 stomach: 12.1 HCAR2 GPR109A, HCA2, HM74A, NIACR1, Puma-g, PUMAG ENSG00000182782 Hydroxycarboxylic acid receptor 2 12 122701293-122703343 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028660 Approved Approved Cell Junctions Group enriched Tissue enhanced spleen: 36.5 esophagus: 25.6 HCAR3 GPR109B, HCA3, HM74 ENSG00000255398 Hydroxycarboxylic acid receptor 3 12 122714756-122716892 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028660 Approved Approved Cell Junctions Mixed Tissue enhanced bone marrow: 16.7;spleen: 22.1 appendix: 12.6 HCRTR1 OX1R ENSG00000121764 Hypocretin (orexin) receptor 1 1 31617686-31632518 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA014018 Approved Not detected Mixed adrenal gland: 1.2 HCRTR2 OX2R ENSG00000137252 Hypocretin (orexin) receptor 2 6 55106460-55282620 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA054516 Supported Not detected Not detected kidney: 0.6 HRH1 ENSG00000196639 Histamine receptor H1 3 11137093-11263557 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA029740 Uncertain Supported Plasma membrane
Cytosol Pancreatic cancer:1.27e-5 (unfavourable) Mixed Mixed cerebral cortex: 12.4 HRH2 ENSG00000113749 Histamine receptor H2 5 175658030-175686242 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013770 Approved Tissue enhanced Tissue enhanced bone marrow: 26.4 placenta: 17.9 HRH4 AXOR35, GPCR105, GPRv53, H4R, HH4R ENSG00000134489 Histamine receptor H4 18 24460629-24479957 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA035009 Uncertain Not detected Not detected skin: 0.7 HTR1A 5-HT1A, ADRB2RL1, ADRBRL1 ENSG00000178394 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 5 63960356-63962507 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA018073 Uncertain Not detected Group enriched 10 cerebral cortex: 1.9;ovary: 3.9 testis: 0.2 HTR1B 5-HT1B, 5-HT1DB, HTR1D2, S12 ENSG00000135312 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6 77462205-77463464 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA028808 Approved Uncertain Plasma membrane Mixed Tissue enhanced placenta: 13.7;stomach: 5.8 cerebral cortex: 2.8 HTR1E 5-HT1E ENSG00000168830 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 6 86937306-87016683 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA004931 Approved Not detected Tissue enhanced endometrium: 2.4;ovary: 4.9 cerebral cortex: 1.9 HTR1F 5-HT1F, HTR1EL ENSG00000179097 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 3 87990696-87993835 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA005555 Uncertain Not detected Tissue enhanced placenta: 2.7 cerebral cortex: 1.0 HTR2A 5-HT2A, HTR2 ENSG00000102468 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13 46831550-46897076 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014011 Supported Not detected Tissue enriched 8 cerebral cortex: 32.3 smooth muscle: 3.8 HTR2B 5-HT(2B), 5-HT2B ENSG00000135914 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2 231108230-231125118 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level CAB011448, HPA012867, HPA063658 Approved Approved Nucleoplasm Mixed Tissue enhanced cervix, uterine: 31.1;endometrium: 30.0;smooth muscle: 23.0 adrenal gland: 19.1 HTR4 5-HT4 ENSG00000164270 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5 148451032-148677235 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA040591 Approved Not detected Tissue enhanced duodenum: 5.0;small intestine: 10.2 heart muscle: 3.5 HTR5A 5-HT5A ENSG00000157219 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 7 155070324-155085749 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level CAB017467 Approved Not detected Tissue enriched 11 cerebral cortex: 8.6 testis: 0.7 HTR7 5-HT7 ENSG00000148680 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 10 90740823-90857698 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, RAS pathway related proteins Evidence at protein level CAB022708 Uncertain Supported Nuclear speckles
Plasma membrane
Cytosol Group enriched Group enriched 8 parathyroid gland: 43.9;testis: 16.0 urinary bladder: 3.9 HTT HD, IT15 ENSG00000197386 Huntingtin 4 3074681-3243959 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB002756, HPA026114 Supported Supported Nucleoplasm
Cytosol Renal cancer:2.41e-12 (favourable), Head and neck cancer:3.26e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 26.8 ITPR1 ACV, Insp3r1, IP3R1, PPP1R94, SCA15, SCA16, SCA29 ENSG00000150995 Inositol 1,4,5-trisphosphate receptor, type 1 3 4493348-4847840 Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA014765, HPA016487 Approved Approved Vesicles Thyroid cancer:3.43e-4 (unfavourable) Expressed in all Tissue enhanced parathyroid gland: 104.9 thyroid gland: 47.2 ITPR3 IP3R3 ENSG00000096433 Inositol 1,4,5-trisphosphate receptor, type 3 6 33620365-33696574 Plasma proteins, Predicted membrane proteins Evidence at protein level HPA003915, HPA064704 Approved Uncertain Vesicles Expressed in all Mixed skin: 65.2 KCNC4 C1orf30, HKSHIIIC, Kv3.4 ENSG00000116396 Potassium channel, voltage gated Shaw related subfamily C, member 4 1 110211343-110283100 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA014740 Approved Approved Nucleoli
Cytosol Mixed Mixed cerebral cortex: 6.3 KCNG1 K13, KCNG, kH2, Kv6.1 ENSG00000026559 Potassium channel, voltage gated modifier subfamily G, member 1 20 51003656-51023129 Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA039530, HPA040024 Approved Validated Vesicles Tissue enhanced Tissue enhanced endometrium: 23.4;seminal vesicle: 17.9 placenta: 10.8 KCNG2 KCNF2, Kv6.2 ENSG00000178342 Potassium channel, voltage gated modifier subfamily G, member 2 18 79863668-79900184 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA048628 Approved Not detected Not detected cerebral cortex: 0.4 KCNG3 Kv6.3 ENSG00000171126 Potassium channel, voltage gated modifier subfamily G, member 3 2 42442017-42494097 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA041625 Approved Cytoplasmic bodies Mixed Tissue enhanced adrenal gland: 1.2;cerebral cortex: 1.3;testis: 1.1 colon,endometrium: 0.4 KCNG4 Kv6.4 ENSG00000168418 Potassium channel, voltage gated modifier subfamily G, member 4 16 84218667-84239750 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA039161 Uncertain Not detected Not detected adrenal gland: 0.6 KCNH7 erg3, HERG3, Kv11.3 ENSG00000184611 Potassium channel, voltage gated eag related subfamily H, member 7 2 162371407-162838730 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA018039 Uncertain Not detected Tissue enriched 6 cerebral cortex: 4.7 testis: 0.7 KCNMA1 KCa1.1, mSLO1, SLO ENSG00000156113 Potassium channel, calcium activated large conductance subfamily M alpha, member 1 10 76869601-77638595 Disease related genes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA054648 Approved Mixed Tissue enhanced smooth muscle: 147.6 endometrium: 122.5 KCNN2 hSK2, KCa2.2 ENSG00000080709 Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 5 114360945-114496500 Plasma proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA038221 Uncertain Uncertain Nucleoplasm
Cytosol Group enriched Tissue enhanced adrenal gland: 27.4;prostate: 18.5 liver: 15.9 KCNN3 hSK3, KCa2.3, SKCA3 ENSG00000143603 Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1 154697455-154870280 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA017990, HPA057127 Uncertain Approved Nucleoplasm Renal cancer:1.97e-4 (unfavourable) Tissue enhanced Tissue enhanced cerebral cortex: 25.4 fallopian tube: 9.4 KCNT1 KCa4.1, KIAA1422, SLACK, Slo2.2 ENSG00000107147 Potassium channel, sodium activated subfamily T, member 1 9 135702185-135795508 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA059880 Uncertain Tissue enhanced Group enriched 5 cerebral cortex: 11.7;ovary: 3.9;skeletal muscle: 3.9;spleen: 6.7 testis: 1.2 KDELR1 ERD2, ERD2.1, HDEL ENSG00000105438 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 19 48382570-48391553 Predicted membrane proteins, Transporters Evidence at protein level CAB017455 Approved Supported Golgi apparatus
Vesicles Liver cancer:1.61e-4 (unfavourable), Head and neck cancer:3.49e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 259.3 KDELR2 ELP-1, ERD2.2 ENSG00000136240 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 7 6445953-6484242 Predicted membrane proteins Evidence at protein level HPA016459 Approved Renal cancer:6.79e-8 (unfavourable), Head and neck cancer:1.03e-5 (unfavourable), Glioma:8.16e-5 (unfavourable) Expressed in all Expressed in all placenta: 202.3 KDELR3 ENSG00000100196 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 22 38468062-38483447 Predicted membrane proteins Evidence at protein level HPA043477, HPA076405 Uncertain Validated Endoplasmic reticulum Renal cancer:6.05e-10 (unfavourable), Liver cancer:1.19e-4 (unfavourable) Expressed in all Mixed cervix, uterine: 46.3 KISS1R AXOR12, GPR54, HOT7T175 ENSG00000116014 KISS1 receptor 19 917287-921015 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA071913 Supported Vesicles
Plasma membrane Renal cancer:3.33e-6 (unfavourable) Tissue enhanced Tissue enriched 5 cerebral cortex: 1.2 appendix,lymph node,placenta: 0.2 LGR4 GPR48 ENSG00000205213 Leucine-rich repeat containing G protein-coupled receptor 4 11 27365961-27472775 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA030267, HPA054350 Uncertain Approved Microtubule organizing center Renal cancer:2.00e-7 (favourable) Expressed in all Expressed in all kidney: 55.7 LGR5 FEX, GPR49, GPR67, HG38 ENSG00000139292 Leucine-rich repeat containing G protein-coupled receptor 5 12 71439770-71586310 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA012530 Approved Lung cancer:5.09e-4 (favourable) Group enriched Tissue enhanced fallopian tube: 26.3;placenta: 26.7 seminal vesicle: 9.7 LGR6 FLJ14471 ENSG00000133067 Leucine-rich repeat containing G protein-coupled receptor 6 1 202193901-202319781 G-protein coupled receptors, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA008556 Approved Approved Nucleoplasm
Plasma membrane Glioma:2.00e-4 (unfavourable) Tissue enhanced Tissue enhanced fallopian tube: 14.1 gallbladder: 9.6 LHCGR HHG, LCGR, LGR2, LHR, ULG5 ENSG00000138039 Luteinizing hormone/choriogonadotropin receptor 2 48686775-48755730 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB009814 Uncertain Not detected Group enriched 5 adipose tissue: 1.3;adrenal gland: 1.1;ovary: 1.5;testis: 4.3;thyroid gland: 1.1 breast,esophagus: 0.3 LMBRD1 bA810I22.1, C6orf209, cblF, FLJ11240 ENSG00000168216 LMBR1 domain containing 1 6 69675802-69797111 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA019547 Uncertain Renal cancer:1.07e-7 (favourable) Expressed in all Expressed in all parathyroid gland: 170.0 LPAR1 edg-2, EDG2, Gpcr26, GPR26, LPA1, Mrec1.3, rec.1.3, vzg-1 ENSG00000198121 Lysophosphatidic acid receptor 1 9 110873263-111038458 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA050667 Approved Nuclear speckles
Plasma membrane Expressed in all Mixed cervix, uterine: 90.9 LPAR2 EDG-4, EDG4, LPA2 ENSG00000064547 Lysophosphatidic acid receptor 2 19 19623668-19628930 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA019616 Approved Renal cancer:1.61e-7 (unfavourable), Stomach cancer:1.43e-4 (favourable) Expressed in all Mixed testis: 40.7 LPAR3 Edg-7, EDG7, HOFNH30, LP-A3, LPA3, RP4-678I3 ENSG00000171517 Lysophosphatidic acid receptor 3 1 84811602-84893213 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013421 Uncertain Supported Plasma membrane Ovarian cancer:4.31e-5 (favourable) Tissue enhanced Tissue enhanced fallopian tube: 66.2 prostate: 21.5 LPAR4 GPR23, LPA4, P2RY9, P2Y5-LIKE, P2Y9 ENSG00000147145 Lysophosphatidic acid receptor 4 X 78747709-78757094 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA054951, HPA055571 Uncertain Tissue enhanced Tissue enhanced ovary: 4.5 cerebral cortex: 2.2 LPAR5 GPR92, GPR93, KPG_010, LPA5 ENSG00000184574 Lysophosphatidic acid receptor 5 12 6618835-6636447 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013170 Approved Thyroid cancer:6.56e-5 (favourable) Mixed Mixed tonsil: 11.0 LPAR6 P2RY5, P2Y5 ENSG00000139679 Lysophosphatidic acid receptor 6 13 48389567-48444704 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA028934, HPA076273 Approved Supported Vesicles
Plasma membrane Renal cancer:3.60e-4 (unfavourable), Lung cancer:6.22e-4 (favourable) Expressed in all Expressed in all placenta: 100.1 LTB4R BLTR, CMKRL1, GPR16, LTB4R1, P2RY7, P2Y7 ENSG00000213903 Leukotriene B4 receptor 14 24311450-24318036 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA003873 Approved Renal cancer:3.44e-15 (unfavourable), Pancreatic cancer:1.85e-4 (favourable) Expressed in all Tissue enhanced skin: 165.5 esophagus: 42.8 LTB4R2 BLT2, BLTR2, JULF2, NOP9 ENSG00000213906 Leukotriene B4 receptor 2 14 24305734-24312053 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022689, HPA029680, HPA072921 Uncertain Supported Nucleoplasm
Plasma membrane Mixed Tissue enhanced skin: 40.6 spleen: 11.2 MAS1 ENSG00000130368 MAS1 proto-oncogene, G protein-coupled receptor 6 159906690-159916530 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA013564 Uncertain Not detected Tissue enhanced cerebral cortex: 1.8 cervix, uterine: 0.7 MAS1L dJ994E9.2, MAS-L, MRG ENSG00000204687 MAS1 proto-oncogene like, G protein-coupled receptor 6 29486697-29487956 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA017983 Uncertain Approved Nucleoplasm
Plasma membrane
Cytosol Not detected Tissue enhanced cervix, uterine: 5.1 epididymis: 2.3 MBOAT1 dJ434O11.1, LPEAT1, MGC44669, OACT1 ENSG00000172197 Membrane bound O-acyltransferase domain containing 1 6 20102145-20212399 Enzymes, Predicted membrane proteins Evidence at protein level HPA052996 Approved Mitochondria Pancreatic cancer:9.15e-4 (unfavourable) Expressed in all Mixed fallopian tube: 55.1 MBTPS2 KFSD, S2P ENSG00000012174 Membrane-bound transcription factor peptidase, site 2 X 21839636-21885424 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA005494, CAB009486 Approved Approved Nucleoplasm
Mitochondria
Cytosol Expressed in all Expressed in all parathyroid gland: 19.0 MC4R ENSG00000166603 Melanocortin 4 receptor 18 60371110-60372775 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA016719 Uncertain Tissue enhanced Group enriched 10 cerebral cortex: 3.0;fallopian tube: 5.0 epididymis: 0.4 MC5R ENSG00000176136 Melanocortin 5 receptor 18 13824155-13826743 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA042365 Uncertain Not detected Tissue enriched 6 epididymis: 3.0 esophagus,testis: 0.5 MFSD10 IT10C3, TETRAN ENSG00000109736 Major facilitator superfamily domain containing 10 4 2930561-2934859 Predicted membrane proteins Evidence at protein level HPA043209 Uncertain Approved Nucleoplasm
Nuclear membrane Renal cancer:5.68e-5 (unfavourable), Liver cancer:4.49e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 41.3 MFSD2A FLJ14490, MFSD2 ENSG00000168389 Major facilitator superfamily domain containing 2A 1 39955112-39969968 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA043107 Uncertain Approved Plasma membrane
Cytosol
Cytoplasmic bodies Renal cancer:4.22e-6 (unfavourable), Urothelial cancer:2.33e-4 (favourable) Mixed Tissue enhanced epididymis: 114.6;seminal vesicle: 109.6 testis: 63.3 MLC1 KIAA0027, LVM, MLC, VL ENSG00000100427 Megalencephalic leukoencephalopathy with subcortical cysts 1 22 50059391-50085902 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA003040, HPA067533 Supported Tissue enriched Tissue enriched 8 cerebral cortex: 181.4 bone marrow: 23.1 MMD MMA, PAQR11 ENSG00000108960 Monocyte to macrophage differentiation-associated 17 55392613-55421992 Predicted membrane proteins, Transporters Evidence at transcript level HPA026978 Approved Vesicles Colorectal cancer:3.52e-5 (favourable), Liver cancer:6.39e-5 (unfavourable), Renal cancer:2.85e-4 (unfavourable), Endometrial cancer:3.88e-4 (unfavourable), Thyroid cancer:8.62e-4 (unfavourable) Expressed in all Tissue enhanced adipose tissue: 141.1 cerebral cortex: 73.3 MPDU1 CDGIf, Lec35, PQLC5, SL15 ENSG00000129255 Mannose-P-dolichol utilization defect 1 17 7583529-7592789 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA014845 Uncertain Supported Endoplasmic reticulum
Mitochondria Expressed in all Expressed in all rectum: 70.2 MRGPRD mrgD ENSG00000172938 MAS-related GPR, member D 11 68980021-68980986 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA031346 Uncertain Not detected Not detected seminal vesicle: 0.4 MRGPRE GPR167, mrgE ENSG00000184350 MAS-related GPR, member E 11 3227698-3232386 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA046556 Uncertain Tissue enhanced Tissue enhanced cervix, uterine: 1.0 endometrium,spleen: 0.6 MRGPRF GPR140, GPR168, MGC21621, mrgF ENSG00000172935 MAS-related GPR, member F 11 69004395-69013409 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA028811 Approved Supported Nuclear membrane
Plasma membrane Expressed in all Mixed smooth muscle: 77.8 MRGPRG GPR169, mrgG ENSG00000182170 MAS-related GPR, member G 11 3217944-3218813 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA058909 Uncertain Not detected Tissue enriched 18 testis: 1.7 all non-specific tissues: 0.0 MRGPRX2 MRGX2 ENSG00000183695 MAS-related GPR, member X2 11 19054455-19060681 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA055220 Approved Not detected Tissue enhanced breast: 1.2;skin: 1.2 cervix, uterine: 0.6 MT-CO3 CO3, COIII, COX3, MTCO3 ENSG00000198938 Mitochondrially encoded cytochrome c oxidase III MT 9207-9990 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA042788 Approved Approved Nucleoplasm Pancreatic cancer:1.04e-4 (favourable), Liver cancer:2.01e-4 (favourable) Expressed in all Expressed in all heart muscle: 56545.8 MT-ND1 MTND1, NAD1, ND1 ENSG00000198888 Mitochondrially encoded NADH dehydrogenase 1 MT 3307-4262 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level CAB033779 Approved Pancreatic cancer:3.26e-4 (favourable), Breast cancer:3.63e-4 (favourable) Expressed in all Expressed in all skeletal muscle: 23823.0 NIPA1 MGC35570, SPG6 ENSG00000170113 Non imprinted in Prader-Willi/Angelman syndrome 1 15 22773063-22829791 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA023269 Uncertain Expressed in all Tissue enhanced cerebral cortex: 38.3 parathyroid gland: 16.6 NIPAL3 DJ462O23.2, NPAL3 ENSG00000001461 NIPA-like domain containing 3 1 24415794-24472976 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA039978 Approved Approved Nucleoplasm Renal cancer:3.03e-7 (favourable), Thyroid cancer:3.95e-4 (favourable) Expressed in all Expressed in all prostate: 94.7 NMBR BB1 ENSG00000135577 Neuromedin B receptor 6 142058330-142088799 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA026665 Supported Plasma membrane
Cytosol Not detected Group enriched 5 fallopian tube: 1.3;testis: 2.6 cerebral cortex: 0.3 NMUR1 FM-3, GPC-R, GPR66, NMU1R ENSG00000171596 Neuromedin U receptor 1 2 231523160-231530495 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at transcript level HPA027895 Uncertain Mixed Mixed adipose tissue: 5.5 NMUR2 NMU2R ENSG00000132911 Neuromedin U receptor 2 5 152391532-152433368 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA045836 Approved Group enriched Tissue enhanced stomach: 1.1;testis: 2.2 thyroid gland: 0.9 NOX3 GP91-3 ENSG00000074771 NADPH oxidase 3 6 155395370-155455903 Predicted membrane proteins, Transporters Evidence at protein level HPA073837 Uncertain Vesicles Not detected Not detected adrenal gland: 0.1 NOX4 KOX, KOX-1 ENSG00000086991 NADPH oxidase 4 11 89324356-89498187 Predicted membrane proteins, Transporters Evidence at protein level HPA015475 Uncertain Approved Nucleus Renal cancer:6.14e-4 (favourable) Mixed Tissue enriched 12 kidney: 133.6 parathyroid gland: 10.7 NPFFR1 GPR147, NPFF1R1, OT7T022 ENSG00000148734 Neuropeptide FF receptor 1 10 70247329-70283676 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA037521 Uncertain Tissue enhanced Tissue enhanced testis: 2.1 cerebral cortex,lymph node: 0.8 NPFFR2 GPR74, NPFF2, NPGPR ENSG00000056291 Neuropeptide FF receptor 2 4 72031804-72148067 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA026825 Approved Plasma membrane
Actin filaments Mixed Tissue enhanced placenta: 2.3;seminal vesicle: 4.5 epididymis: 1.1 NPSR1 GPR154, GPRA, PGR14 ENSG00000187258 Neuropeptide S receptor 1 7 34658239-34878332 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA007489 Supported Tissue enhanced Not detected stomach: 0.5 NPY1R NPYR ENSG00000164128 Neuropeptide Y receptor Y1 4 163323961-163344832 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA029903 Approved Nucleus
Mitochondria
Cytosol Breast cancer:7.68e-5 (favourable) Tissue enriched Tissue enhanced spleen: 153.9 breast: 39.0 NPY4R PP1, PPYR1, Y4 ENSG00000204174 Neuropeptide Y receptor Y4 10 46461099-46465881 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA027863 Approved Tissue enhanced Tissue enhanced colon: 9.0;rectum: 10.5 skin: 6.4 NTSR1 NTR ENSG00000101188 Neurotensin receptor 1 (high affinity) 20 62708837-62762771 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA050299 Supported Plasma membrane Tissue enhanced Not detected cerebral cortex: 0.5 OPN1SW BCP, BOP, CBT ENSG00000128617 Opsin 1 (cone pigments), short-wave-sensitive 7 128772491-128775790 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA013562, HPA014083 Supported Renal cancer:2.26e-8 (unfavourable), Stomach cancer:5.98e-8 (unfavourable), Liver cancer:8.50e-5 (unfavourable), Urothelial cancer:9.33e-4 (unfavourable) Expressed in all Mixed smooth muscle: 14.7 OPN3 ECPN, encephalopsin, ERO, NMO-1, PPP1R116 ENSG00000054277 Opsin 3 1 241590102-241677376 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB013682, HPA064443 Uncertain Approved Nucleoplasm Cervical cancer:3.17e-5 (unfavourable), Glioma:2.51e-4 (unfavourable) Expressed in all Tissue enhanced placenta: 26.8 lung: 12.7 OPN5 dJ402H5.1, neuropsin, TMEM13 ENSG00000124818 Opsin 5 6 47781982-47832780 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA026084 Supported Not detected Tissue enriched 42 testis: 4.3 heart muscle: 0.1 OPRD1 ENSG00000116329 Opioid receptor, delta 1 1 28812142-28871267 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013744 Uncertain Tissue enhanced Tissue enhanced cerebral cortex: 2.6 adrenal gland: 0.8 OPRK1 KOR, OPRK ENSG00000082556 Opioid receptor, kappa 1 8 53225716-53251697 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022595 Uncertain Tissue enhanced Group enriched 7 cerebral cortex: 3.6;prostate: 3.2;testis: 1.8 placenta,skeletal muscle: 0.3 OPRM1 MOR1 ENSG00000112038 Opioid receptor, mu 1 6 154010496-154246867 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014509, HPA067435 Supported Supported Not detected Tissue enhanced testis: 4.2 adrenal gland,esophagus: 1.2 OR10A7 ENSG00000179919 Olfactory receptor, family 10, subfamily A, member 7 12 55221025-55221975 G-protein coupled receptors, Predicted membrane proteins No evidence HPA055111 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR10AD1 OR10AD1P ENSG00000172640 Olfactory receptor, family 10, subfamily AD, member 1 12 48202083-48203387 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA049913 Uncertain Not detected Mixed testis: 1.2 OR10C1 hs6M1-17, OR10C1P, OR10C2 ENSG00000279941 Olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene) 6 29440016-29440954 Predicted membrane proteins No evidence HPA049336 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR10D3 HTPCRX09, OR10D3P ENSG00000197309 Olfactory receptor, family 10, subfamily D, member 3 (non-functional) 11 124185216-124186245 G-protein coupled receptors, Predicted membrane proteins No evidence HPA049991 Uncertain Not detected Not detected testis: 0.7 OR10G3 ENSG00000169208 Olfactory receptor, family 10, subfamily G, member 3 14 21569803-21570744 G-protein coupled receptors, Predicted membrane proteins No evidence HPA019766 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR10K1 ENSG00000173285 Olfactory receptor, family 10, subfamily K, member 1 1 158465562-158466503 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA059125 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR10K2 ENSG00000180708 Olfactory receptor, family 10, subfamily K, member 2 1 158419928-158420866 G-protein coupled receptors, Predicted membrane proteins No evidence HPA059125 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR10Q1 ENSG00000180475 Olfactory receptor, family 10, subfamily Q, member 1 11 58227882-58228918 G-protein coupled receptors, Predicted membrane proteins No evidence HPA046968 Uncertain Not detected Not detected placenta: 0.1 OR10R2 OR10R2Q ENSG00000198965 Olfactory receptor, family 10, subfamily R, member 2 1 158479878-158480885 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA059775, HPA060399 Uncertain Not detected Not detected thyroid gland: 0.1 OR10S1 ENSG00000196248 Olfactory receptor, family 10, subfamily S, member 1 11 123976661-123977781 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA019038 Uncertain Not detected Not detected thyroid gland: 0.1 OR10V1 ENSG00000172289 Olfactory receptor, family 10, subfamily V, member 1 11 59712823-59713864 G-protein coupled receptors, Predicted membrane proteins No evidence HPA060076 Uncertain Not detected Not detected cervix, uterine: 0.2 OR10X1 OR10X1P ENSG00000186400 Olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene) 1 158578919-158579899 G-protein coupled receptors, Predicted membrane proteins No evidence HPA060990 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR10Z1 ENSG00000198967 Olfactory receptor, family 10, subfamily Z, member 1 1 158606439-158607380 G-protein coupled receptors, Predicted membrane proteins No evidence HPA058072 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR11H1 OR22-1 ENSG00000130538 Olfactory receptor, family 11, subfamily H, member 1 22 15528158-15529139 G-protein coupled receptors, Predicted membrane proteins No evidence HPA047370 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR11H12 ENSG00000257115 Olfactory receptor, family 11, subfamily H, member 12 14 18601045-18602129 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047370 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR11H2 C14orf15, OR11H2P, OR11H8P ENSG00000258453 Olfactory receptor, family 11, subfamily H, member 2 14 19712936-19713920 G-protein coupled receptors, Predicted membrane proteins No evidence HPA047370 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR11H4 ENSG00000176198 Olfactory receptor, family 11, subfamily H, member 4 14 20242739-20243820 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA052790 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR13A1 ENSG00000256574 Olfactory receptor, family 13, subfamily A, member 1 10 45302654-45315608 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA057237 Uncertain Tissue enhanced Not detected urinary bladder: 0.5 OR13C3 ENSG00000204246 Olfactory receptor, family 13, subfamily C, member 3 9 104535749-104536856 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA053978 Uncertain Not detected Not detected testis: 0.7 OR13D1 ENSG00000179055 Olfactory receptor, family 13, subfamily D, member 1 9 104694422-104695462 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA055921 Uncertain Not detected Not detected testis: 0.5 OR14A2 OR5AX1, OR5AX1P ENSG00000241128 Olfactory receptor, family 14, subfamily A, member 2 1 247723099-247724043 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA052685 Uncertain Not detected Tissue enriched 51 testis: 5.1 all non-specific tissues: 0.0 OR14J1 hs6M1-28, OR5U1 ENSG00000204695 Olfactory receptor, family 14, subfamily J, member 1 6 29306690-29307655 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA045575 Uncertain Not detected Not detected testis: 0.1 OR14K1 OR5AY1 ENSG00000153230 Olfactory receptor, family 14, subfamily K, member 1 1 247738615-247739559 G-protein coupled receptors, Predicted membrane proteins No evidence HPA016643 Uncertain Not detected Not detected testis: 0.3 OR1B1 OR9-B ENSG00000171484 Olfactory receptor, family 1, subfamily B, member 1 (gene/pseudogene) 9 122628579-122629535 G-protein coupled receptors, Predicted membrane proteins No evidence HPA058654 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR1L3 OR9-D ENSG00000171481 Olfactory receptor, family 1, subfamily L, member 3 9 122675130-122676104 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058878 Uncertain Not detected Not detected cerebral cortex: 0.1 OR1Q1 HSTPCR106, OR1Q2, OR1Q3, OR9-A, OST226, OST226OR9-A, TPCR106 ENSG00000165202 Olfactory receptor, family 1, subfamily Q, member 1 9 122614738-122615682 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA044828 Uncertain Not detected Not detected epididymis: 0.9 OR1S2 ENSG00000197887 Olfactory receptor, family 1, subfamily S, member 2 11 58203202-58204181 G-protein coupled receptors, Predicted membrane proteins No evidence HPA049304 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR2A1 ENSG00000221970 Olfactory receptor, family 2, subfamily A, member 1 7 144318125-144319057 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058272 Uncertain Not detected Tissue enhanced thyroid gland: 3.2 ovary: 1.4 OR2A25 OR2A25P, OR2A27 ENSG00000221933 Olfactory receptor, family 2, subfamily A, member 25 7 144074182-144075195 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058272 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR2A4 OR2A10 ENSG00000180658 Olfactory receptor, family 2, subfamily A, member 4 6 131700469-131701401 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058272 Uncertain Tissue enriched Not detected testis: 0.2 OR2A42 ENSG00000212807 Olfactory receptor, family 2, subfamily A, member 42 7 144231911-144232843 G-protein coupled receptors, Predicted membrane proteins No evidence HPA058272 Uncertain Not detected Not detected thyroid gland: 0.8 OR2A7 HSDJ0798C17 ENSG00000243896 Olfactory receptor, family 2, subfamily A, member 7 7 144258607-144259722 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058272 Uncertain Mixed Mixed thyroid gland: 20.0 OR2AE1 OR2AE2 ENSG00000244623 Olfactory receptor, family 2, subfamily AE, member 1 7 99875987-99877057 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA042957 Uncertain Not detected Not detected parathyroid gland: 0.2 OR2AK2 OR2AK1P ENSG00000187080 Olfactory receptor, family 2, subfamily AK, member 2 1 247965233-247966339 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA052544 Uncertain Not detected Not detected testis: 0.2 OR2AT4 ENSG00000171561 Olfactory receptor, family 2, subfamily AT, member 4 11 75088713-75089754 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA060357 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR2B11 ENSG00000177535 Olfactory receptor, family 2, subfamily B, member 11 1 247451029-247451982 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047459 Uncertain Not detected Not detected adipose tissue: 0.7 OR2C3 OR2C4, OR2C5P, OST742 ENSG00000196242 Olfactory receptor, family 2, subfamily C, member 3 1 247530132-247533839 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA053920, HPA058578 Uncertain Supported Plasma membrane Not detected Expressed in all parathyroid gland: 26.6 OR2D3 ENSG00000178358 Olfactory receptor, family 2, subfamily D, member 3 11 6920974-6922043 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA052551 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR2K2 HSHTPCRH06, HTPCRH06, OR2AR1P ENSG00000171133 Olfactory receptor, family 2, subfamily K, member 2 9 111327483-111328520 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA024261 Uncertain Not detected Not detected testis: 0.3 OR2M4 HSHTPCRX18, HTPCRX18, OST710, TPCR100 ENSG00000171180 Olfactory receptor, family 2, subfamily M, member 4 1 248238929-248239864 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA051308 Uncertain Not detected Not detected cerebral cortex: 0.2 OR2T10 ENSG00000184022 Olfactory receptor, family 2, subfamily T, member 10 1 248592830-248593768 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA052019 Uncertain Tissue enhanced Tissue enriched 13 kidney: 7.1 prostate: 0.5 OR2T11 OR2T11Q ENSG00000183130 Olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene) 1 248626178-248627128 G-protein coupled receptors, Predicted membrane proteins No evidence HPA047416 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR2V1 OR2V1P, OST265 ENSG00000185372 Olfactory receptor, family 2, subfamily V, member 1 5 181124357-181125304 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA049953 Uncertain Not detected Tissue enriched 24 fallopian tube: 2.5 testis: 0.1 OR2V2 OR2V3, OST713 ENSG00000182613 Olfactory receptor, family 2, subfamily V, member 2 5 181154943-181155890 G-protein coupled receptors, Predicted membrane proteins No evidence HPA049953 Uncertain Not detected Not detected fallopian tube: 0.4 OR2W3 OR2W3P, OR2W8P, OST718 ENSG00000238243 Olfactory receptor, family 2, subfamily W, member 3 1 247895587-247896531 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA045594 Uncertain Tissue enhanced Tissue enhanced bone marrow: 7.8;thyroid gland: 10.5 cerebral cortex: 2.9 OR2Z1 OR2Z2 ENSG00000181733 Olfactory receptor, family 2, subfamily Z, member 1 19 8730954-8732009 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA048760 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4A47 ENSG00000237388 Olfactory receptor, family 4, subfamily A, member 47 11 48488717-48489780 G-protein coupled receptors, Predicted membrane proteins No evidence HPA059763 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4B1 OST208 ENSG00000175619 Olfactory receptor, family 4, subfamily B, member 1 11 48216792-48217762 G-protein coupled receptors, Predicted membrane proteins No evidence HPA059443 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4C15 ENSG00000181939 Olfactory receptor, family 4, subfamily C, member 15 11 55554307-55555419 G-protein coupled receptors, Predicted membrane proteins No evidence HPA061939 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4C16 ENSG00000181935 Olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene) 11 55572128-55573060 G-protein coupled receptors, Plasma proteins, Predicted membrane proteins No evidence HPA059128 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4C3 ENSG00000176547 Olfactory receptor, family 4, subfamily C, member 3 11 48324920-48328471 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA049116 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4D5 ENSG00000171014 Olfactory receptor, family 4, subfamily D, member 5 11 123939543-123940637 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA045005 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4F16 ENSG00000273547 Olfactory receptor, family 4, subfamily F, member 16 1 685716-686654 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047705 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4F21 OR4F21P ENSG00000176269 Olfactory receptor, family 4, subfamily F, member 21 8 166049-167043 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047705 Uncertain Not detected Not detected testis: 0.2 OR4F29 ENSG00000278566 Olfactory receptor, family 4, subfamily F, member 29 1 450740-451678 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047705 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4F3 ENSG00000230178 Olfactory receptor, family 4, subfamily F, member 3 5 181367268-181368262 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047705 Uncertain Not detected Not detected testis: 0.6 OR4K1 ENSG00000155249 Olfactory receptor, family 4, subfamily K, member 1 14 19935608-19936683 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA028877 Uncertain Not detected Not detected testis: 0.3 OR4K15 OR4K15Q ENSG00000169488 Olfactory receptor, family 4, subfamily K, member 15 14 19975444-19976659 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA055732 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4M1 ENSG00000176299 Olfactory receptor, family 4, subfamily M, member 1 14 19780242-19781357 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058889 Uncertain Not detected Tissue enriched 10 testis: 1.0 all non-specific tissues: 0.0 OR4M2 ENSG00000274102 Olfactory receptor, family 4, subfamily M, member 2 15 22080527-22081659 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058889 Uncertain Not detected Tissue enriched 10 testis: 1.2 cerebral cortex: 0.1 OR4N4 ENSG00000183706 Olfactory receptor, family 4, subfamily N, member 4 15 22094431-22095556 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA057442 Uncertain Uncertain Centrosome Not detected Tissue enriched 103 testis: 10.3 cervix, uterine: 0.1 OR4P4 OR4P3P ENSG00000181927 Olfactory receptor, family 4, subfamily P, member 4 11 55638358-55639296 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA059458 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR4Q3 C14orf13, OR4Q4 ENSG00000182652 Olfactory receptor, family 4, subfamily Q, member 3 14 19747428-19748369 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA049924 Uncertain Not detected Tissue enriched 20 testis: 2.7 cerebral cortex: 0.1 OR4X2 ENSG00000279556 Olfactory receptor, family 4, subfamily X, member 2 (gene/pseudogene) 11 48245104-48246015 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA060249 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR51A7 ENSG00000176895 Olfactory receptor, family 51, subfamily A, member 7 11 4907370-4908308 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA061356 Uncertain Not detected Not detected testis: 0.2 OR51B5 ENSG00000242180 Olfactory receptor, family 51, subfamily B, member 5 11 5342586-5343524 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA063124 Uncertain Not detected Not detected testis: 0.3 OR51D1 OR51D1Q ENSG00000197428 Olfactory receptor, family 51, subfamily D, member 1 11 4639715-4640838 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA061240 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR51E1 GPR136, GPR164, OR51E1P, OR52A3P ENSG00000180785 Olfactory receptor, family 51, subfamily E, member 1 11 4643420-4655488 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level CAB019995, HPA051439 Approved Renal cancer:1.23e-6 (unfavourable) Tissue enriched Tissue enhanced adipose tissue: 6.3;placenta: 9.5;prostate: 8.0 urinary bladder: 1.8 OR51M1 ENSG00000184698 Olfactory receptor, family 51, subfamily M, member 1 11 5389399-5390379 G-protein coupled receptors, Predicted membrane proteins No evidence HPA056773 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR51T1 ENSG00000176900 Olfactory receptor, family 51, subfamily T, member 1 11 4881819-4882883 G-protein coupled receptors, Predicted membrane proteins No evidence HPA046877 Uncertain Not detected Not detected prostate: 0.1 OR52D1 ENSG00000181609 Olfactory receptor, family 52, subfamily D, member 1 11 5488685-5489749 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA046965 Uncertain Not detected Tissue enriched 6 testis: 2.3 epididymis: 0.3 OR52E2 ENSG00000176787 Olfactory receptor, family 52, subfamily E, member 2 11 5058650-5059627 G-protein coupled receptors, Predicted membrane proteins No evidence HPA045748 Uncertain Not detected Not detected testis: 0.4 OR52I2 ENSG00000226288 Olfactory receptor, family 52, subfamily I, member 2 11 4586791-4587905 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA049343 Uncertain Not detected Not detected epididymis: 0.2 OR52N1 ENSG00000181001 Olfactory receptor, family 52, subfamily N, member 1 11 5787854-5788816 Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins No evidence HPA054028 Uncertain Not detected Not detected adipose tissue: 0.1 OR56B1 OR56B1P ENSG00000181023 Olfactory receptor, family 56, subfamily B, member 1 11 5736517-5737491 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA045043 Uncertain Not detected Not detected parathyroid gland: 0.3 OR5A2 ENSG00000172324 Olfactory receptor, family 5, subfamily A, member 2 11 59421943-59422976 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047135, HPA049575 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5D16 ENSG00000205029 Olfactory receptor, family 5, subfamily D, member 16 11 55838752-55839738 G-protein coupled receptors, Predicted membrane proteins No evidence HPA046711 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5F1 OR11-10 ENSG00000149133 Olfactory receptor, family 5, subfamily F, member 1 11 55993681-55994625 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA059360 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5J2 ENSG00000174957 Olfactory receptor, family 5, subfamily J, member 2 11 56176618-56177556 G-protein coupled receptors, Predicted membrane proteins No evidence HPA059466 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5L1 OST262 ENSG00000186117 Olfactory receptor, family 5, subfamily L, member 1 (gene/pseudogene) 11 55811467-55812402 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047524 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5L2 HSHTPCRX16, HTPCRX16 ENSG00000205030 Olfactory receptor, family 5, subfamily L, member 2 11 55827219-55828154 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047524 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5P3 JCG1 ENSG00000182334 Olfactory receptor, family 5, subfamily P, member 3 11 7825037-7825972 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA060787 Uncertain Not detected Not detected epididymis,skin: 0.1 OR5R1 OR5R1P ENSG00000174942 Olfactory receptor, family 5, subfamily R, member 1 (gene/pseudogene) 11 56417258-56418232 G-protein coupled receptors, Predicted membrane proteins No evidence HPA049992 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5T1 OR5T1P ENSG00000181698 Olfactory receptor, family 5, subfamily T, member 1 11 56275639-56276619 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA050952 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5T3 OR5T3Q ENSG00000172489 Olfactory receptor, family 5, subfamily T, member 3 11 56252200-56253222 G-protein coupled receptors, Predicted membrane proteins No evidence HPA044986 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR5V1 hs6M1-21 ENSG00000243729 Olfactory receptor, family 5, subfamily V, member 1 6 29355230-29431967 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA046707 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR6B1 OR7-3 ENSG00000221813 Olfactory receptor, family 6, subfamily B, member 1 7 144003929-144004983 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA053164 Uncertain Not detected Not detected testis: 0.3 OR6B2 OR6B2P ENSG00000182083 Olfactory receptor, family 6, subfamily B, member 2 2 240028965-240030456 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047529 Uncertain Not detected Not detected testis: 0.6 OR6B3 OR6B3P, OR6B3Q ENSG00000178586 Olfactory receptor, family 6, subfamily B, member 3 2 240045077-240046072 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047529 Uncertain Not detected Tissue enhanced epididymis: 1.9 testis: 0.7 OR6C6 ENSG00000188324 Olfactory receptor, family 6, subfamily C, member 6 12 55294288-55295232 G-protein coupled receptors, Predicted membrane proteins No evidence HPA051090 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR6K3 ENSG00000203757 Olfactory receptor, family 6, subfamily K, member 3 1 158717168-158718163 G-protein coupled receptors, Predicted membrane proteins No evidence HPA055949 Uncertain Not detected Not detected bone marrow: 0.8 OR6M1 ENSG00000196099 Olfactory receptor, family 6, subfamily M, member 1 11 123805335-123806387 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA048674 Uncertain Not detected Not detected testis: 0.3 OR6N2 ENSG00000188340 Olfactory receptor, family 6, subfamily N, member 2 1 158776682-158777635 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA056637 Uncertain Not detected Tissue enriched 12 bone marrow: 1.1 all non-specific tissues: 0.0 OR6P1 ENSG00000186440 Olfactory receptor, family 6, subfamily P, member 1 1 158562651-158563604 G-protein coupled receptors, Predicted membrane proteins No evidence HPA047466 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR6T1 ENSG00000181499 Olfactory receptor, family 6, subfamily T, member 1 11 123942785-123943873 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA060893 Uncertain Not detected Not detected testis: 0.6 OR7A5 HTPCR2 ENSG00000188269 Olfactory receptor, family 7, subfamily A, member 5 19 14792490-14835376 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA053823 Uncertain Tissue enriched Tissue enhanced epididymis: 5.4;parathyroid gland: 5.2;testis: 2.8 breast,seminal vesicle: 0.9 OR7C1 OR19-5, OR7C4 ENSG00000127530 Olfactory receptor, family 7, subfamily C, member 1 19 14799146-14800211 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA047127 Uncertain Tissue enriched Tissue enhanced epididymis: 3.4;parathyroid gland: 4.9;testis: 3.9 seminal vesicle: 1.5 OR7C2 OR19-18, OR7C3 ENSG00000127529 Olfactory receptor, family 7, subfamily C, member 2 19 14941489-14942448 G-protein coupled receptors, Predicted membrane proteins No evidence HPA047295 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR8B4 OR8B4P ENSG00000198657 Olfactory receptor, family 8, subfamily B, member 4 (gene/pseudogene) 11 124423942-124424871 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA049884 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR8D1 OR8D3, OST004 ENSG00000196341 Olfactory receptor, family 8, subfamily D, member 1 11 124309812-124310837 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA059510 Uncertain Not detected Tissue enriched 21 testis: 2.0 all non-specific tissues: 0.0 OR8K1 ENSG00000150261 Olfactory receptor, family 8, subfamily K, member 1 11 56346039-56346998 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA055233 Uncertain Not detected Not detected all non-specific tissues: 0.0 OR8S1 ENSG00000197376 Olfactory receptor, family 8, subfamily S, member 1 12 48507354-48529897 G-protein coupled receptors, Predicted membrane proteins No evidence HPA045595 Uncertain Approved Plasma membrane Not detected Not detected breast,testis: 0.1 OR9K2 ENSG00000170605 Olfactory receptor, family 9, subfamily K, member 2 12 55129681-55130802 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA015808 Uncertain Not detected Not detected all non-specific tissues: 0.0 OXER1 GPCR, GPR170, TG1019 ENSG00000162881 Oxoeicosanoid (OXE) receptor 1 2 42762481-42764261 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA051433 Uncertain Expressed in all Mixed small intestine: 9.3 OXGR1 aKGR, GPR80, GPR99, P2RY15, P2Y15 ENSG00000165621 Oxoglutarate (alpha-ketoglutarate) receptor 1 13 96985719-96994730 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA067673 Supported Plasma membrane Mixed Mixed breast: 5.2 P2RY1 P2Y1 ENSG00000169860 Purinergic receptor P2Y, G-protein coupled, 1 3 152834693-152841439 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA015577 Approved Renal cancer:2.04e-7 (unfavourable) Mixed Tissue enhanced placenta: 33.7 esophagus: 20.0 P2RY10 P2Y10 ENSG00000078589 Purinergic receptor P2Y, G-protein coupled, 10 X 78945332-78961954 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA036757, HPA065766 Approved Renal cancer:3.63e-4 (unfavourable) Mixed Tissue enhanced lymph node: 33.5;spleen: 23.0;tonsil: 24.9 appendix: 20.1 P2RY11 P2Y11 ENSG00000244165 Purinergic receptor P2Y, G-protein coupled, 11 19 10111538-10115372 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014232 Approved Urothelial cancer:1.77e-4 (favourable) Expressed in all Mixed lymph node: 7.3 P2RY12 HORK3, P2Y12, SP1999 ENSG00000169313 Purinergic receptor P2Y, G-protein coupled, 12 3 151337380-151384812 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA013796, HPA014518 Supported Tissue enriched Tissue enriched 6 cerebral cortex: 84.0 lymph node: 13.3 P2RY13 FKSG77, GPR86, GPR94, P2Y13 ENSG00000181631 Purinergic receptor P2Y, G-protein coupled, 13 3 151326312-151329548 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA049047 Supported Expressed in all Tissue enhanced spleen: 51.9 appendix: 28.7 P2RY14 GPR105, KIAA0001 ENSG00000174944 Purinergic receptor P2Y, G-protein coupled, 14 3 151212117-151278467 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level CAB022646 Uncertain Renal cancer:1.72e-5 (unfavourable) Mixed Tissue enhanced placenta: 45.4 esophagus: 23.4 P2RY2 P2U ENSG00000175591 Purinergic receptor P2Y, G-protein coupled, 2 11 73218298-73236352 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022642 Uncertain Uncertain Cytosol Pancreatic cancer:2.19e-5 (unfavourable) Mixed Tissue enhanced esophagus: 19.0 skeletal muscle: 14.9 P2RY4 NRU, P2P, P2Y4, UNR ENSG00000186912 Pyrimidinergic receptor P2Y, G-protein coupled, 4 X 70258170-70259764 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022644 Uncertain Not detected Tissue enhanced small intestine: 3.1 rectum,skin: 0.6 P2RY6 P2Y6 ENSG00000171631 Pyrimidinergic receptor P2Y, G-protein coupled, 6 11 73264505-73298617 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022740 Uncertain Renal cancer:2.50e-7 (unfavourable) Mixed Tissue enhanced placenta: 16.8;spleen: 36.2 appendix: 11.0 P2RY8 P2Y8 ENSG00000182162 Purinergic receptor P2Y, G-protein coupled, 8 X 1462572-1537107 Cancer-related genes, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA003631 Supported Head and neck cancer:7.80e-5 (favourable), Liver cancer:1.73e-4 (favourable), Pancreatic cancer:6.54e-4 (favourable) Expressed in all Tissue enhanced lymph node: 43.1 tonsil: 29.0 PAQR3 ENSG00000163291 Progestin and adipoQ receptor family member III 4 78887127-78939438 Predicted membrane proteins Evidence at protein level HPA058453 Uncertain Expressed in all Tissue enhanced testis: 1.1 cerebral cortex,duodenum,lymph node: 0.3 PARL PRO2207, PSARL, PSARL1, RHBDS1 ENSG00000175193 Presenilin associated, rhomboid-like 3 183829385-183884933 Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA019545 Approved Supported Mitochondria Urothelial cancer:9.11e-5 (favourable) Expressed in all Expressed in all epididymis: 71.5 PGAP1 Bst1, FLJ12377, SPG67 ENSG00000197121 Post-GPI attachment to proteins 1 2 196833004-196927796 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA069704 Uncertain Mixed Mixed skin: 14.7 PGAP3 CAB2, MGC9753, PER1, PERLD1, PP1498 ENSG00000161395 Post-GPI attachment to proteins 3 17 39671122-39696797 Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA016591 Approved Approved Plasma membrane
Cytosol Renal cancer:3.89e-4 (favourable), Liver cancer:3.94e-4 (favourable), Ovarian cancer:6.82e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 35.5 PHTF1 PHTF ENSG00000116793 Putative homeodomain transcription factor 1 1 113696831-113759489 Plasma proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA059486 Approved Nucleoli
Nuclear bodies Renal cancer:1.21e-6 (unfavourable) Expressed in all Tissue enhanced testis: 54.1 parathyroid gland: 18.8 PHTF2 DKFZp434D166 ENSG00000006576 Putative homeodomain transcription factor 2 7 77798792-77957503 Predicted membrane proteins, Transcription factors Evidence at protein level HPA012312 Uncertain Approved Nucleoplasm
Cytosol Renal cancer:3.09e-7 (unfavourable), Thyroid cancer:2.78e-4 (unfavourable) Expressed in all Mixed parathyroid gland: 60.8 PIGC ENSG00000135845 Phosphatidylinositol glycan anchor biosynthesis, class C 1 172370189-172444086 Enzymes, Predicted membrane proteins Evidence at protein level HPA036663 Uncertain Renal cancer:1.43e-8 (unfavourable), Liver cancer:4.49e-4 (unfavourable) Expressed in all Expressed in all epididymis: 47.0 PIGQ GPI1, hGPI1 ENSG00000007541 Phosphatidylinositol glycan anchor biosynthesis, class Q 16 566995-584136 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA039105, HPA039828, HPA061414 Approved Approved Nucleoplasm
Golgi apparatus
Vesicles Renal cancer:2.53e-6 (favourable) Expressed in all Expressed in all bone marrow: 24.2 PIGW FLJ37433, Gwt1 ENSG00000277161 Phosphatidylinositol glycan anchor biosynthesis, class W 17 36535020-36539310 Disease related genes, Predicted membrane proteins Evidence at protein level HPA023499 Approved Plasma membrane Expressed in all Mixed appendix: 5.3 PKD2 Pc-2, PC2, PKD4, TRPP2 ENSG00000118762 Polycystic kidney disease 2 (autosomal dominant) 4 88007668-88077777 Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level CAB004544, HPA015794 Approved Validated Endoplasmic reticulum Expressed in all Expressed in all endometrium: 100.4 PKD2L2 TRPP5 ENSG00000078795 Polycystic kidney disease 2-like 2 5 137887968-137942747 Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at transcript level HPA041903, HPA043634 Approved Approved Plasma membrane
Cytosol Not detected Tissue enriched 11 testis: 15.6 thyroid gland: 1.4 POMT1 LGMD2K ENSG00000130714 Protein-O-mannosyltransferase 1 9 131502902-131523806 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA065252 Approved Golgi apparatus Pancreatic cancer:3.90e-5 (favourable), Renal cancer:4.68e-5 (favourable) Expressed in all Expressed in all testis: 62.7 PPAN-P2RY11 ENSG00000243207 PPAN-P2RY11 readthrough 19 10106223-10114780 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA014232 Uncertain Not detected Mixed fallopian tube: 2.4 PRLHR GPR10, PrRPR ENSG00000119973 Prolactin releasing hormone receptor 10 118589989-118595699 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA039361 Supported Not detected Group enriched 7 adrenal gland: 6.5;cerebral cortex: 3.5;endometrium: 3.9;smooth muscle: 5.4 seminal vesicle: 0.7 PROKR1 GPR73, GPR73a, PKR1, ZAQ ENSG00000169618 Prokineticin receptor 1 2 68643589-68658247 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA029396 Uncertain Not detected Group enriched 8 adipose tissue: 1.7;adrenal gland: 1.4;epididymis: 4.3 testis: 0.3 PROKR2 dJ680N4.3, GPR73b, GPR73L1, GPRg2, KAL3, PKR2 ENSG00000101292 Prokineticin receptor 2 20 5302040-5314369 Disease related genes, G-protein coupled receptors, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA047281 Uncertain Not detected Tissue enhanced cerebral cortex: 3.0 bone marrow: 0.8 PRRT3 FLJ33674 ENSG00000163704 Proline-rich transmembrane protein 3 3 9945542-9952394 Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA035127, HPA035128 Uncertain Approved Nucleus
Plasma membrane
Cytosol Mixed Tissue enhanced cerebral cortex: 19.5;parathyroid gland: 27.5 fallopian tube: 12.3 PSEN1 AD3, FAD, PS1, S182 ENSG00000080815 Presenilin 1 14 73136418-73223691 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB006844, HPA030760, HPA067496 Approved Approved Nucleus
Golgi apparatus
Cell Junctions Renal cancer:1.52e-8 (favourable), Liver cancer:1.99e-5 (unfavourable) Expressed in all Expressed in all cerebral cortex: 66.1 PSEN2 AD3L, AD4, PS2, STM2 ENSG00000143801 Presenilin 2 1 226870184-226896105 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level CAB013634, HPA038005 Supported Nucleus Expressed in all Expressed in all parathyroid gland: 29.1 PTAFR ENSG00000169403 Platelet-activating factor receptor 1 28147166-28193936 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA027543 Approved Supported Nucleoplasm
Vesicles
Plasma membrane Expressed in all Tissue enhanced appendix: 42.1 bone marrow: 26.2 PTCHD3 FLJ44037, PTR ENSG00000182077 Patched domain containing 3 10 27398187-27414368 Predicted membrane proteins Evidence at protein level HPA044613 Supported Not detected Tissue enriched 9 testis: 4.1 adipose tissue: 0.4 PTGDR2 CD294, CRTH2, DP2, GPR44 ENSG00000183134 Prostaglandin D2 receptor 2 11 60850940-60855971 CD markers, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014259 Uncertain Mixed Tissue enhanced small intestine: 7.3;stomach: 7.5 parathyroid gland: 5.3 PTGER3 EP3 ENSG00000050628 Prostaglandin E receptor 3 (subtype EP3) 1 70852353-71047808 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA010689 Uncertain Renal cancer:3.50e-4 (unfavourable) Group enriched Group enriched 7 adipose tissue: 58.5;endometrium: 114.7;kidney: 87.6;smooth muscle: 103.9 skin: 14.0 PTGER4 EP4 ENSG00000171522 Prostaglandin E receptor 4 (subtype EP4) 5 40679498-40693735 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA011226, HPA012756 Approved Urothelial cancer:2.48e-4 (favourable) Expressed in all Expressed in all bone marrow: 48.1 PTH1R PTHR, PTHR1 ENSG00000160801 Parathyroid hormone 1 receptor 3 46877746-46903799 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA007978 Approved Renal cancer:6.79e-6 (favourable) Tissue enhanced Tissue enhanced kidney: 158.5 adrenal gland: 36.8 PTH2R PTHR2 ENSG00000144407 Parathyroid hormone 2 receptor 2 208359714-208854503 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA010655 Approved Tissue enhanced Mixed bone marrow: 2.9 QRFPR GPR103 ENSG00000186867 Pyroglutamylated RFamide peptide receptor 4 121329312-121381059 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA014300 Uncertain Renal cancer:3.09e-4 (favourable) Tissue enriched Not detected heart muscle: 0.6 RABGAP1 GAPCenA, TBC1D11 ENSG00000011454 RAB GTPase activating protein 1 9 122940833-123104866 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA041651, HPA064860, HPA072273 Approved Validated Cytosol Renal cancer:6.06e-6 (favourable), Breast cancer:8.09e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 66.1 RHBDF1 C16orf8, Dist1, EGFR-RS, FLJ2235, iRhom1 ENSG00000007384 Rhomboid 5 homolog 1 (Drosophila) 16 58059-76355 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA077399 Uncertain Vesicles Renal cancer:2.49e-5 (unfavourable) Expressed in all Mixed placenta: 39.6 RHBDF2 FLJ22341, iRhom2, RHBDL5, RHBDL6, TOC, TOCG ENSG00000129667 Rhomboid 5 homolog 2 (Drosophila) 17 76470891-76501790 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA018080 Uncertain Renal cancer:3.96e-11 (unfavourable) Expressed in all Expressed in all appendix: 51.0 RHBDL1 RHBDL, RRP ENSG00000103269 Rhomboid, veinlet-like 1 (Drosophila) 16 675666-678268 Enzymes, Predicted membrane proteins Evidence at protein level HPA030359, HPA030360, HPA046593 Uncertain Approved Nucleoplasm Breast cancer:8.12e-4 (favourable) Expressed in all Tissue enhanced cerebral cortex: 8.0 adrenal gland: 3.3 RHBDL2 FLJ20435 ENSG00000158315 Rhomboid, veinlet-like 2 (Drosophila) 1 38885807-38941799 Enzymes, Predicted membrane proteins Evidence at protein level HPA043807 Approved Mixed Mixed rectum: 22.5 RHBDL3 RHBDL4, VRHO ENSG00000141314 Rhomboid, veinlet-like 3 (Drosophila) 17 32266176-32324661 Enzymes, Predicted membrane proteins Evidence at transcript level HPA059607 Uncertain Tissue enhanced Tissue enhanced cerebral cortex: 20.7 adrenal gland: 5.5 RHO CSNBAD1, OPN2, RP4 ENSG00000163914 Rhodopsin 3 129528640-129535169 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA013440, CAB022486 Supported Not detected Not detected cerebral cortex: 0.3 RP11-294C11.1 ENSG00000182974 Olfactory receptor 4M2 15 21637909-21638992 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA058889 Uncertain Not detected Tissue enriched 24 testis: 2.3 all non-specific tissues: 0.0 RP11-294C11.3 ENSG00000279408 15 21651844-21653039 Predicted membrane proteins Evidence at transcript level HPA057442 Uncertain Uncertain Centrosome Not detected Tissue enriched 17 testis: 14.6 cerebral cortex: 0.8 RP11-566K11.2 ENSG00000198211 16 89919165-89936092 Predicted membrane proteins Evidence at protein level CAB011512, HPA043640, HPA046280 Uncertain Validated Microtubules Not detected Tissue enhanced skin: 1.1 testis: 0.7 RXFP1 LGR7, RXFPR1 ENSG00000171509 Relaxin/insulin-like family peptide receptor 1 4 158315311-158653372 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA027067 Approved Tissue enriched Tissue enhanced cerebral cortex: 21.7;endometrium: 10.1 adrenal gland: 5.7 RXFP3 GPCR135, RLN3R1, RXFPR3, SALPR ENSG00000182631 Relaxin/insulin-like family peptide receptor 3 5 33936386-33938237 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA027833 Uncertain Not detected Not detected adrenal gland: 0.3 RYR1 CCO, MHS, MHS1, PPP1R137, RYR ENSG00000196218 Ryanodine receptor 1 (skeletal) 19 38433699-38587564 Disease related genes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA056416 Supported Approved Golgi apparatus
Vesicles
Cytosol Mixed Tissue enriched 30 skeletal muscle: 572.4 esophagus: 18.7 S1PR1 CD363, D1S3362, edg-1, EDG1 ENSG00000170989 Sphingosine-1-phosphate receptor 1 1 101236888-101241518 Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level CAB010104, HPA075568 Supported Supported Vesicles Urothelial cancer:8.78e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 86.5 S1PR2 AGR16, EDG5, Gpcr13, H218 ENSG00000267534 Sphingosine-1-phosphate receptor 2 19 10221435-10231272 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA014307 Approved Renal cancer:4.36e-10 (unfavourable) Expressed in all Tissue enhanced placenta: 26.9 lymph node: 13.5 S1PR4 EDG6 ENSG00000125910 Sphingosine-1-phosphate receptor 4 19 3172346-3180332 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA060601, HPA067232 Uncertain Mitochondria Head and neck cancer:1.45e-6 (favourable), Cervical cancer:1.33e-4 (favourable), Endometrial cancer:2.22e-4 (favourable), Renal cancer:2.87e-4 (unfavourable), Breast cancer:3.13e-4 (favourable) Expressed in all Tissue enhanced lymph node: 18.3;spleen: 27.0 appendix: 14.5 S1PR5 Edg-8, EDG8 ENSG00000180739 Sphingosine-1-phosphate receptor 5 19 10512742-10517931 FDA approved drug targets, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA029683 Supported Renal cancer:6.71e-7 (unfavourable) Group enriched Tissue enhanced cerebral cortex: 14.9;skin: 22.1 spleen: 12.2 SCTR ENSG00000080293 Secretin receptor 2 119439843-119525301 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at transcript level HPA007269 Uncertain Tissue enhanced Tissue enhanced duodenum: 27.4;lung: 13.0;pancreas: 14.3 stomach: 4.2 SLC10A3 DXS253E, P3 ENSG00000126903 Solute carrier family 10, member 3 X 154487306-154490690 Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA021656 Approved Approved Intermediate filaments Colorectal cancer:4.15e-5 (unfavourable), Cervical cancer:4.53e-4 (favourable), Pancreatic cancer:7.22e-4 (unfavourable) Expressed in all Expressed in all gallbladder: 33.2 SLC10A7 C4orf13, DKFZp313H0531, DKFZp566M114, DKFZp779O2438, MGC25043 ENSG00000120519 Solute carrier family 10, member 7 4 146253975-146521964 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA039996, HPA057906 Uncertain Approved Nucleoli Expressed in all Mixed epididymis: 16.0 SLC13A3 NADC3, SDCT2 ENSG00000158296 Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 20 46557823-46684467 Predicted membrane proteins, Transporters Evidence at protein level HPA014353, HPA014736 Supported Mixed Tissue enriched 7 kidney: 428.6 placenta: 60.6 SLC14A1 HsT1341, JK, RACH1, RACH2 ENSG00000141469 Solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 18 45724127-45752520 Blood group antigen proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA058353, HPA059570 Supported Supported Vesicles Group enriched Group enriched 5 prostate: 132.1;urinary bladder: 51.9 cerebral cortex: 18.2 SLC15A1 HPECT1, HPEPT1, PEPT1 ENSG00000088386 Solute carrier family 15 (oligopeptide transporter), member 1 13 98683801-98752654 Predicted membrane proteins, Transporters Evidence at protein level HPA002827 Uncertain Approved Nucleoplasm
Cytosol Mixed Group enriched 5 duodenum: 157.7;gallbladder: 68.0;small intestine: 230.1 skin: 27.9 SLC16A1 MCT, MCT1 ENSG00000155380 Solute carrier family 16 (monocarboxylate transporter), member 1 1 112911847-112957013 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA003324, CAB017489, HPA071055 Supported Validated Plasma membrane
Cell Junctions Renal cancer:6.78e-8 (unfavourable), Endometrial cancer:8.37e-6 (unfavourable), Pancreatic cancer:2.10e-4 (unfavourable), Lung cancer:4.05e-4 (unfavourable) Expressed in all Mixed testis: 32.0 SLC16A3 MCT3, MCT4 ENSG00000141526 Solute carrier family 16 (monocarboxylate transporter), member 3 17 82228397-82261129 Predicted membrane proteins, Transporters Evidence at protein level CAB017490, HPA021451 Approved Supported Nuclear membrane
Plasma membrane Liver cancer:1.19e-7 (unfavourable), Renal cancer:3.71e-7 (unfavourable), Lung cancer:2.02e-5 (unfavourable), Cervical cancer:6.07e-4 (unfavourable) Expressed in all Expressed in all skeletal muscle: 74.4 SLC1A6 EAAT4 ENSG00000105143 Solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 19 14950034-15022990 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA041505, HPA044066 Supported Uncertain Intermediate filaments Urothelial cancer:6.88e-6 (unfavourable) Tissue enriched Group enriched 6 cerebral cortex: 16.2;skin: 8.9;testis: 36.8 epididymis: 3.7 SLC22A16 CT2, FLIPT2, OAT6, OKB1 ENSG00000004809 Solute carrier family 22 (organic cation/carnitine transporter), member 16 6 110424687-110476641 Predicted membrane proteins Evidence at protein level HPA036902 Uncertain Tissue enriched Group enriched 8 bone marrow: 13.0;parathyroid gland: 16.1;testis: 38.4 smooth muscle: 2.7 SLC26A11 ENSG00000181045 Solute carrier family 26 (anion exchanger), member 11 17 80219699-80253500 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA029893 Approved Supported Nucleoplasm
Golgi apparatus
Vesicles Liver cancer:1.82e-6 (unfavourable), Pancreatic cancer:1.43e-5 (favourable), Endometrial cancer:1.55e-5 (unfavourable) Expressed in all Expressed in all adrenal gland: 34.5 SLC2A13 HMIT ENSG00000151229 Solute carrier family 2 (facilitated glucose transporter), member 13 12 39755021-40106089 Predicted membrane proteins, Transporters Evidence at protein level HPA006584 Approved Approved Nuclear membrane Mixed Tissue enhanced cerebral cortex: 49.5;parathyroid gland: 73.3 cervix, uterine: 20.3 SLC2A8 GLUT8, GLUTX1 ENSG00000136856 Solute carrier family 2 (facilitated glucose transporter), member 8 9 127397138-127408424 Predicted membrane proteins, Transporters Evidence at protein level HPA011935 Uncertain Approved Vesicles Cervical cancer:2.57e-6 (favourable), Renal cancer:6.55e-6 (favourable), Pancreatic cancer:9.86e-6 (favourable) Expressed in all Expressed in all testis: 50.1 SLC30A7 ZNT7, ZnTL2 ENSG00000162695 Solute carrier family 30 (zinc transporter), member 7 1 100896076-100981753 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA018034 Uncertain Supported Golgi apparatus Expressed in all Mixed parathyroid gland: 20.6 SLC35A2 UGALT, UGAT, UGT, UGT1, UGT2, UGTL ENSG00000102100 Solute carrier family 35 (UDP-galactose transporter), member A2 X 48903180-48911958 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA036087 Approved Supported Golgi apparatus Liver cancer:9.64e-5 (unfavourable), Breast cancer:3.16e-4 (unfavourable), Stomach cancer:8.23e-4 (favourable) Expressed in all Expressed in all fallopian tube: 44.1 SLC35B1 UGTREL1 ENSG00000121073 Solute carrier family 35, member B1 17 49700943-49709014 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA048655, HPA057418 Approved Approved Nucleus
Endoplasmic reticulum
Vesicles Renal cancer:5.69e-7 (unfavourable) Expressed in all Expressed in all thyroid gland: 52.0 SLC37A3 DKFZp761N0624 ENSG00000157800 Solute carrier family 37, member 3 7 140293693-140404433 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA014713, HPA061841 Supported Cytosol Liver cancer:4.78e-5 (unfavourable), Cervical cancer:9.54e-4 (unfavourable) Expressed in all Expressed in all endometrium: 72.5 SLC38A7 FLJ10815 ENSG00000103042 Solute carrier family 38, member 7 16 58665109-58685104 Predicted membrane proteins, Transporters Evidence at protein level HPA041777 Approved Approved Nucleoplasm
Plasma membrane
Cytosol Renal cancer:2.87e-4 (favourable), Endometrial cancer:6.87e-4 (favourable) Expressed in all Mixed testis: 34.8 SLC39A11 C17orf26 ENSG00000133195 Solute carrier family 39, member 11 17 72645949-73092712 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA021455 Approved Nucleoplasm Expressed in all Expressed in all thyroid gland: 60.0 SLC39A2 ZIP2 ENSG00000165794 Solute carrier family 39 (zinc transporter), member 2 14 20999255-21001871 Predicted membrane proteins Evidence at protein level HPA030489 Uncertain Mixed Group enriched 12 esophagus: 19.0;prostate: 20.5;seminal vesicle: 46.3;skin: 34.2 tonsil: 2.6 SLC39A9 FLJ11274 ENSG00000029364 Solute carrier family 39, member 9 14 69398015-69462388 Predicted membrane proteins, Transporters Evidence at protein level HPA007921, HPA075390 Approved Approved Endoplasmic reticulum Renal cancer:1.05e-6 (favourable) Expressed in all Expressed in all parathyroid gland,thyroid gland: 44.1 SLC43A3 DKFZp762A227, Eeg1, FOAP-13, PRO1659, SEEEG-1 ENSG00000134802 Solute carrier family 43, member 3 11 57406954-57427580 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA030551 Approved Renal cancer:3.97e-13 (unfavourable) Expressed in all Expressed in all thyroid gland: 121.6 SLC4A1 AE1, CD233, DI, EPB3, FR, RTA1A, SW, WD, WR ENSG00000004939 Solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 17 44248385-44268141 Blood group antigen proteins, CD markers, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA015584, CAB034438, HPA063911 Supported Tissue enriched Tissue enriched 8 bone marrow: 238.4 kidney: 29.9 SLC50A1 HsSWEET1, RAG1AP1, RP11-540D14.5, RZPDo834D038D, SCP, slv, SWEET1 ENSG00000169241 Solute carrier family 50 (sugar efflux transporter), member 1 1 155135344-155138857 Predicted membrane proteins, Transporters Evidence at protein level HPA018095 Approved Renal cancer:3.88e-7 (unfavourable) Expressed in all Expressed in all epididymis: 133.2 SLC51A OSTalpha ENSG00000163959 Solute carrier family 51, alpha subunit 3 196211487-196243178 Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at transcript level HPA039123 Approved Liver cancer:7.54e-4 (favourable) Tissue enriched Tissue enhanced duodenum: 30.1;liver: 35.2;small intestine: 72.7 colon: 10.2 SLC52A1 FLJ10060, GPCR42, GPR172B, hRFT1, PAR2, RFVT1 ENSG00000132517 Solute carrier family 52 (riboflavin transporter), member 1 17 5032600-5052009 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB011449 Uncertain Cervical cancer:9.54e-4 (favourable) Mixed Group enriched 10 duodenum: 37.1;placenta: 26.0;skin: 13.3;small intestine: 26.8 parathyroid gland: 2.6 SLC7A8 LAT2, LPI-PC1 ENSG00000092068 Solute carrier family 7 (amino acid transporter light chain, L system), member 8 14 23125295-23183674 Predicted membrane proteins, Transporters Evidence at protein level CAB046015, HPA051950, HPA060672 Supported Urothelial cancer:1.52e-4 (unfavourable), Liver cancer:1.97e-4 (unfavourable), Lung cancer:3.15e-4 (favourable) Expressed in all Tissue enriched 8 parathyroid gland: 1066.4 kidney: 131.5 SLCO1B3 OATP1B3, OATP8, SLC21A8 ENSG00000111700 Solute carrier organic anion transporter family, member 1B3 12 20810702-20916911 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA004943, HPA050892 Supported Supported Plasma membrane Tissue enhanced Tissue enriched 7 liver: 138.5 cervix, uterine: 19.4 SLCO2B1 OATP-B, OATP2B1, SLC21A9 ENSG00000137491 Solute carrier organic anion transporter family, member 2B1 11 75100563-75206549 FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA020659 Uncertain Expressed in all Expressed in all liver: 123.0 SLCO6A1 CT48, MGC26949, OATP6A1, OATPY ENSG00000205359 Solute carrier organic anion transporter family, member 6A1 5 102371782-102499016 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA054126 Supported Not detected Tissue enriched 136 testis: 53.7 placenta: 0.3 SMO FZD11, SMOH ENSG00000128602 Smoothened, frizzled class receptor 7 129188872-129213545 Cancer-related genes, FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB011446 Approved Expressed in all Mixed ovary: 30.3 SOAT1 ACAT, SOAT, STAT ENSG00000057252 Sterol O-acyltransferase 1 1 179293714-179358680 Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level CAB009533, HPA047171 Supported Validated Endoplasmic reticulum Expressed in all Tissue enhanced adrenal gland: 219.3 prostate: 44.0 SOAT2 ACAT2 ENSG00000167780 Sterol O-acyltransferase 2 12 53103518-53124538 Enzymes, Predicted membrane proteins Evidence at protein level HPA062409 Uncertain Group enriched Tissue enhanced duodenum: 12.4;small intestine: 22.4 spleen: 3.5 SSTR1 ENSG00000139874 Somatostatin receptor 1 14 38207999-38213067 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA031506 Approved Renal cancer:4.28e-4 (favourable) Mixed Tissue enhanced cerebral cortex: 13.6;duodenum: 14.6;stomach: 21.4 small intestine: 9.3 SSTR2 ENSG00000180616 Somatostatin receptor 2 17 73165012-73176633 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA007264 Uncertain Supported Cytosol Renal cancer:9.04e-7 (unfavourable), Pancreatic cancer:6.63e-4 (favourable) Mixed Tissue enhanced cerebral cortex: 22.9 spleen: 5.9 SSTR3 ENSG00000278195 Somatostatin receptor 3 22 37204238-37212322 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022647 Approved Tissue enhanced Tissue enhanced testis: 10.9 cerebral cortex: 3.9 SSTR4 ENSG00000132671 Somatostatin receptor 4 20 23035386-23036812 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA064252 Uncertain Not detected Not detected cerebral cortex: 0.8 SSTR5 ENSG00000162009 Somatostatin receptor 5 16 1078781-1080142 FDA approved drug targets, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins Evidence at protein level HPA066503 Supported Plasma membrane Mixed Tissue enhanced adrenal gland: 1.2 heart muscle: 0.8 SUCNR1 GPR91 ENSG00000198829 Succinate receptor 1 3 151873643-151884619 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level CAB022745 Uncertain Mixed Tissue enhanced kidney: 42.0 thyroid gland: 15.8 SURF4 ERV29, FLJ22993, MGC102753 ENSG00000148248 Surfeit 4 9 133361449-133376166 Predicted membrane proteins Evidence at protein level HPA064613 Approved Head and neck cancer:1.47e-5 (unfavourable), Breast cancer:5.85e-4 (unfavourable), Liver cancer:8.11e-4 (unfavourable) Expressed in all Expressed in all small intestine: 84.4 SVOPL MGC46715 ENSG00000157703 SVOP-like 7 138594285-138701352 Predicted membrane proteins Evidence at transcript level HPA018035 Uncertain Mixed Tissue enriched 5 parathyroid gland: 14.0 fallopian tube: 2.6 TAAR1 TA1, TAR1, TRAR1 ENSG00000146399 Trace amine associated receptor 1 6 132644984-132646003 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA055614 Approved Tissue enhanced Group enriched 17 fallopian tube: 2.2;stomach: 7.9 duodenum,endometrium,prostate,urinary bladder: 0.2 TAAR5 PNR ENSG00000135569 Trace amine associated receptor 5 6 132588673-132589686 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA051703 Uncertain Not detected Not detected all non-specific tissues: 0.0 TACR1 NK1R, NKIR, SPR, TAC1R ENSG00000115353 Tachykinin receptor 1 2 75046463-75199700 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA074573 Approved Mixed Tissue enhanced cervix, uterine: 7.3 fallopian tube: 4.7 TACR3 NK3R ENSG00000169836 Tachykinin receptor 3 4 103586031-103719816 Disease related genes, G-protein coupled receptors, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA009418 Uncertain Not detected Not detected cerebral cortex: 0.5 TAS1R1 GPR70, T1R1, TR1 ENSG00000173662 Taste receptor, type 1, member 1 1 6555181-6579757 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at transcript level HPA034579, HPA034580 Approved Mixed Tissue enriched 7 testis: 4.2 gallbladder,skin: 0.5 TAS1R3 T1R3 ENSG00000169962 Taste receptor, type 1, member 3 1 1331314-1335306 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA053439 Approved Mixed Group enriched 5 epididymis: 14.7;salivary gland: 3.3 appendix: 1.7 TAS2R1 T2R1, TRB7 ENSG00000169777 Taste receptor, type 2, member 1 5 9628997-9712378 G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA051879 Uncertain Not detected Tissue enriched 41 testis: 13.2 fallopian tube: 0.3 TAS2R38 PTC, T2R61 ENSG00000257138 Taste receptor, type 2, member 38 7 141972631-141973773 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA043862, HPA054366 Uncertain Not detected Not detected rectum,small intestine: 0.3 TAS2R39 ENSG00000236398 Taste receptor, type 2, member 39 7 143183419-143184435 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA053456, HPA060680 Uncertain Not detected Not detected all non-specific tissues: 0.0 TAS2R41 T2R59 ENSG00000221855 Taste receptor, type 2, member 41 7 143477873-143478796 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA057063 Uncertain Not detected Not detected all non-specific tissues: 0.0 TAS2R42 hT2R55, T2R24, T2R55, TAS2R55 ENSG00000186136 Taste receptor, type 2, member 42 12 11185993-11186937 G-protein coupled receptors, Predicted membrane proteins Evidence at transcript level HPA036149 Uncertain Approved Nucleoplasm
Actin filaments
Focal adhesion sites Not detected Not detected all non-specific tissues: 0.0 TBXA2R ENSG00000006638 Thromboxane A2 receptor 19 3594506-3606840 Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA077366 Supported Nuclear speckles
Plasma membrane Renal cancer:1.45e-4 (unfavourable), Pancreatic cancer:7.17e-4 (favourable) Expressed in all Mixed spleen: 5.3 TEX261 MGC32043, TEG-261 ENSG00000144043 Testis expressed 261 2 70985938-70994945 Predicted membrane proteins Evidence at transcript level HPA016631 Approved Approved Nucleoplasm
Cytosol Liver cancer:4.23e-4 (unfavourable), Endometrial cancer:6.17e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 91.4 TM7SF2 ANG1, DHCR14A, NET47 ENSG00000149809 Transmembrane 7 superfamily member 2 11 65111845-65116384 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA030691, HPA072704 Approved Supported Endoplasmic reticulum
Vesicles Renal cancer:8.49e-8 (favourable) Expressed in all Expressed in all adrenal gland: 161.3 TMBIM4 CGI-119, GAAP, LFG4, S1R, ZPRO ENSG00000155957 Transmembrane BAX inhibitor motif containing 4 12 66135846-66170072 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA077642 Supported Golgi apparatus Expressed in all Expressed in all thyroid gland: 164.8 TMBIM6 BAXI1, BI-1, TEGT ENSG00000139644 Transmembrane BAX inhibitor motif containing 6 12 49707725-49764934 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA017378 Approved Renal cancer:1.00e-5 (favourable), Head and neck cancer:1.91e-4 (unfavourable), Breast cancer:3.54e-4 (unfavourable) Expressed in all Expressed in all kidney: 1179.3 TMC8 EVER2, EVIN2 ENSG00000167895 Transmembrane channel-like 8 17 78130770-78142968 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA047387, HPA054429 Uncertain Uncertain Golgi apparatus Renal cancer:1.96e-7 (unfavourable), Cervical cancer:8.45e-6 (favourable), Head and neck cancer:4.19e-5 (favourable) Expressed in all Tissue enhanced lymph node: 120.4;spleen: 107.5 appendix: 75.5 TMCO3 C13orf11, FLJ20623 ENSG00000150403 Transmembrane and coiled-coil domains 3 13 113490995-113554590 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA039561, HPA048126 Uncertain Approved Cytosol Liver cancer:1.14e-5 (unfavourable), Urothelial cancer:4.10e-4 (unfavourable), Cervical cancer:5.80e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 49.2 TMEM115 PL6 ENSG00000126062 Transmembrane protein 115 3 50354749-50359610 Plasma proteins, Predicted membrane proteins Evidence at protein level CAB006319, HPA015497 Supported Supported Golgi apparatus Renal cancer:1.04e-7 (favourable), Liver cancer:3.73e-5 (unfavourable) Expressed in all Expressed in all parathyroid gland: 36.8 TMEM145 FLJ90805 ENSG00000167619 Transmembrane protein 145 19 42313325-42325062 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA060462 Supported Approved Vesicles Tissue enhanced Tissue enriched 6 cerebral cortex: 38.4 adrenal gland: 6.0 TMEM161A FLJ20422, FLJ39645 ENSG00000064545 Transmembrane protein 161A 19 19119169-19138513 Predicted membrane proteins Evidence at protein level HPA043365 Approved Approved Cytosol Stomach cancer:2.99e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 20.9 TMEM161B MGC33214 ENSG00000164180 Transmembrane protein 161B 5 88189633-88269476 Predicted membrane proteins Evidence at protein level HPA044562 Uncertain Expressed in all Expressed in all parathyroid gland: 58.9 TMEM164 FLJ22679, RP13-360B22.2 ENSG00000157600 Transmembrane protein 164 X 110002631-110182734 Predicted membrane proteins Evidence at protein level HPA038784 Approved Approved Vesicles
Cell Junctions Liver cancer:8.17e-6 (unfavourable), Stomach cancer:3.14e-4 (favourable) Expressed in all Expressed in all lung: 26.7 TMEM175 MGC4618 ENSG00000127419 Transmembrane protein 175 4 932387-958656 Predicted membrane proteins, Transporters Evidence at protein level HPA057160 Approved Approved Nucleus
Nuclear membrane Pancreatic cancer:9.85e-5 (favourable) Expressed in all Expressed in all cerebral cortex: 20.8 TMEM184A MGC9712 ENSG00000164855 Transmembrane protein 184A 7 1542235-1560821 Predicted membrane proteins Evidence at protein level HPA053790, HPA071312 Uncertain Approved Nucleoplasm Colorectal cancer:1.12e-4 (unfavourable), Thyroid cancer:9.94e-4 (unfavourable) Mixed Tissue enhanced skin: 33.5 esophagus: 26.7 TMEM184B C22orf5, DKFZP586A1024, FM08, HS5O6A ENSG00000198792 Transmembrane protein 184B 22 38219291-38273034 Predicted membrane proteins, Transporters Evidence at protein level HPA024076 Approved Approved Nucleoplasm
Golgi apparatus
Cytosol Liver cancer:5.94e-6 (unfavourable) Expressed in all Expressed in all cerebral cortex: 57.5 TMEM184C FLJ10846, TMEM34 ENSG00000164168 Transmembrane protein 184C 4 147617383-147672044 Predicted membrane proteins Evidence at protein level HPA054013 Uncertain Approved Nucleoplasm
Vesicles Renal cancer:2.31e-7 (favourable), Pancreatic cancer:6.37e-4 (unfavourable) Expressed in all Group enriched 5 parathyroid gland: 253.7;thyroid gland: 54.5 placenta: 28.5 TMEM241 C18orf45, FLJ44259, MGC11386 ENSG00000134490 Transmembrane protein 241 18 23197144-23437961 Predicted membrane proteins Evidence at protein level HPA029489, HPA059922 Uncertain Approved Golgi apparatus
Vesicles Urothelial cancer:5.80e-4 (unfavourable) Expressed in all Mixed cerebral cortex: 4.3 TMEM39A FLJ10902 ENSG00000176142 Transmembrane protein 39A 3 119429500-119468830 Predicted membrane proteins Evidence at protein level HPA039140 Approved Approved Nucleoplasm
Vesicles Renal cancer:1.00e-5 (unfavourable), Liver cancer:3.26e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 32.9 TMEM45A DERP7, FLJ10134 ENSG00000181458 Transmembrane protein 45A 3 100492619-100577444 Predicted membrane proteins Evidence at protein level HPA024082, HPA062101 Uncertain Approved Intermediate filaments
Microtubules Renal cancer:6.18e-11 (unfavourable), Lung cancer:7.42e-4 (unfavourable) Expressed in all Tissue enriched 10 skin: 563.8 placenta: 58.1 TMEM56 FLJ31842 ENSG00000152078 Transmembrane protein 56 1 95117338-95197607 Predicted membrane proteins Evidence at protein level HPA046762 Uncertain Approved Nuclear speckles Tissue enhanced Tissue enhanced liver: 66.0 heart muscle: 16.1 TMEM82 ENSG00000162460 Transmembrane protein 82 1 15742422-15747982 Predicted membrane proteins Evidence at protein level HPA060282 Uncertain Renal cancer:3.80e-7 (favourable) Tissue enhanced Tissue enhanced duodenum: 23.7;liver: 9.0;small intestine: 19.8 kidney: 7.6 TMEM87A DKFZP564G2022 ENSG00000103978 Transmembrane protein 87A 15 42210452-42273663 Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA018104, HPA018189 Supported Supported Golgi apparatus Expressed in all Expressed in all prostate: 122.4 TMEM87B FLJ14681 ENSG00000153214 Transmembrane protein 87B 2 112055223-112119318 Predicted membrane proteins Evidence at protein level HPA035183 Approved Approved Golgi apparatus
Vesicles Renal cancer:1.52e-7 (unfavourable), Cervical cancer:3.78e-4 (unfavourable), Head and neck cancer:4.28e-4 (unfavourable), Liver cancer:4.72e-4 (unfavourable) Expressed in all Mixed prostate: 43.2 TMEM8A M83, TMEM6, TMEM8 ENSG00000129925 Transmembrane protein 8A 16 370773-387113 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA051281, HPA064673 Approved Supported Nucleoplasm
Cytokinetic bridge Renal cancer:1.29e-5 (favourable) Expressed in all Expressed in all testis: 57.6 TMEM8B C9orf127, NAG-5, NGX6 ENSG00000137103 Transmembrane protein 8B 9 35814451-35854847 Predicted membrane proteins Evidence at protein level HPA052130, HPA062701 Approved Approved Vesicles Renal cancer:1.89e-15 (favourable), Pancreatic cancer:3.14e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 26.7 TMTC1 ARG99, FLJ31400, FLJ41625, OLF ENSG00000133687 Transmembrane and tetratricopeptide repeat containing 1 12 29500840-29784759 Predicted membrane proteins Evidence at protein level HPA016720 Approved Approved Nucleoplasm
Cytosol Endometrial cancer:1.90e-4 (unfavourable), Renal cancer:5.49e-4 (unfavourable) Mixed Tissue enhanced spleen: 61.6 adipose tissue: 41.5 TPCN2 TPC2 ENSG00000162341 Two pore segment channel 2 11 69048897-69090604 Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA016561, HPA027080 Supported Approved Nucleoli Ovarian cancer:1.49e-4 (unfavourable), Head and neck cancer:2.96e-4 (unfavourable) Expressed in all Mixed endometrium: 11.7 TPRA1 FLJ32197, GPR175, TMEM227, TPRA40 ENSG00000163870 Transmembrane protein, adipocyte asscociated 1 3 127573069-127598251 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA019784 Approved Approved Vesicles Liver cancer:6.46e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 38.1 TRAM2 KIAA0057 ENSG00000065308 Translocation associated membrane protein 2 6 52497402-52576915 Predicted membrane proteins Evidence at protein level HPA035092, HPA057925 Approved Approved Cytosol Renal cancer:1.41e-9 (unfavourable), Endometrial cancer:1.88e-4 (unfavourable) Expressed in all Expressed in all placenta: 51.8 TRPC3 ENSG00000138741 Transient receptor potential cation channel, subfamily C, member 3 4 121879027-121951754 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA037969 Uncertain Not detected Tissue enhanced smooth muscle: 4.1 cerebral cortex: 2.1 TRPC6 FSGS2, TRP6 ENSG00000137672 Transient receptor potential cation channel, subfamily C, member 6 11 101451564-101872562 Disease related genes, Plasma proteins, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels Evidence at protein level HPA045098, HPA062164 Approved Approved Nucleoplasm
Cytosol Mixed Tissue enhanced placenta: 29.8 lung: 20.0 TRPC7 ENSG00000069018 Transient receptor potential cation channel, subfamily C, member 7 5 136213320-136365537 Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level CAB022592, HPA031126 Uncertain Uncertain Actin filaments
Focal adhesion sites Not detected Not detected testis: 0.7 TRPM1 CSNB1C, LTRPC1, MLSN1 ENSG00000134160 Transient receptor potential cation channel, subfamily M, member 1 15 31001061-31161273 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Voltage-gated ion channels Evidence at protein level HPA014779, HPA014785 Approved Uncertain Nucleoplasm
Cytosol Tissue enriched Group enriched 27 skin: 4.8;testis: 2.5 kidney: 0.1 TRPM2 EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, TRPC7 ENSG00000142185 Transient receptor potential cation channel, subfamily M, member 2 21 44350163-44443081 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA030976, HPA035260 Approved Approved Nuclear membrane Renal cancer:4.39e-6 (unfavourable), Urothelial cancer:7.59e-4 (favourable), Endometrial cancer:9.28e-4 (favourable) Expressed in all Mixed bone marrow: 18.9 TSHR LGR3 ENSG00000165409 Thyroid stimulating hormone receptor 14 80954989-81146302 Cancer-related genes, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000473 Approved Tissue enriched Tissue enriched 277 thyroid gland: 443.8 lymph node: 1.6 VIPR1 HVR1, RDC1, VPAC1, VPAC1R ENSG00000114812 Vasoactive intestinal peptide receptor 1 3 42489299-42537573 G-protein coupled receptors, Predicted membrane proteins, Transporters Evidence at protein level HPA026777 Approved Tissue enhanced Tissue enhanced lung: 60.0 duodenum: 35.4 VIPR2 VPAC2, VPAC2R ENSG00000106018 Vasoactive intestinal peptide receptor 2 7 159028175-159144957 G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA062707 Approved Tissue enhanced Tissue enhanced seminal vesicle: 28.2 epididymis: 14.8 VMP1 EPG3, TANGO5, TMEM49 ENSG00000062716 Vacuole membrane protein 1 17 59707192-59842255 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA030773, HPA064780 Uncertain Approved Nucleoli
Endoplasmic reticulum Renal cancer:2.77e-8 (unfavourable), Endometrial cancer:1.56e-5 (unfavourable), Liver cancer:8.02e-4 (unfavourable) Expressed in all Expressed in all spleen: 64.7 WLS C1orf139, EVI, FLJ23091, GPR177, mig-14, MRP, wls ENSG00000116729 Wntless Wnt ligand secretion mediator 1 68098473-68233120 Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA069520 Approved Supported Endoplasmic reticulum Renal cancer:3.67e-7 (favourable), Urothelial cancer:3.51e-4 (unfavourable), Breast cancer:4.03e-4 (favourable), Ovarian cancer:9.43e-4 (favourable) Expressed in all Expressed in all epididymis: 160.7 XCR1 CCXCR1, GPR5 ENSG00000173578 Chemokine (C motif) receptor 1 3 46017024-46027742 G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA013169 Uncertain Mixed Tissue enhanced lymph node: 11.0 spleen: 9.3 ZMPSTE24 FACE-1, HGPS, PRO1, STE24, Ste24p ENSG00000084073 Zinc metallopeptidase STE24 1 40258107-40294184 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA006988 Approved Approved Golgi apparatus
Cytosol Liver cancer:5.73e-6 (unfavourable), Thyroid cancer:6.34e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 89.0