Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific AHR bHLHe76 ENSG00000106546 Aryl hydrocarbon receptor 7 17298622-17346152 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB005072, HPA029722, HPA029723 Supported Validated Nucleoplasm
Cytosol Expressed in all Mixed urinary bladder: 57.6 AHRR AHH, AHHR, bHLHe77, KIAA1234 ENSG00000063438 Aryl-hydrocarbon receptor repressor 5 304176-438291 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA021483 Supported Nucleoplasm
Cytosol Mixed Tissue enriched 8 testis: 65.3 skin: 7.9 ARNT bHLHe2, HIF-1beta ENSG00000143437 Aryl hydrocarbon receptor nuclear translocator 1 150809705-150876768 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001759, CAB004318 Supported Supported Nucleus
Nuclear bodies Expressed in all Expressed in all ovary: 46.6 ARNT2 bHLHe1, KIAA0307 ENSG00000172379 Aryl-hydrocarbon receptor nuclear translocator 2 15 80404350-80597937 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001056, CAB005081 Approved Approved Nucleus
Mitochondria Pancreatic cancer:1.46e-6 (favourable), Renal cancer:7.51e-4 (favourable) Expressed in all Tissue enriched 8 cerebral cortex: 154.5 testis: 19.3 ARNTL bHLHe5, BMAL1, JAP3, MOP3, PASD3 ENSG00000133794 Aryl hydrocarbon receptor nuclear translocator-like 11 13276652-13387266 Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level CAB045962, HPA050938 Supported Supported Nucleoplasm
Vesicles Expressed in all Expressed in all testis: 27.5 ARNTL2 bHLHe6, BMAL2, CLIF, MOP9, PASD9 ENSG00000029153 Aryl hydrocarbon receptor nuclear translocator-like 2 12 27332854-27425289 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA059074, HPA065355 Uncertain Validated Nucleus
Nucleoli Pancreatic cancer:5.29e-6 (unfavourable), Renal cancer:1.56e-5 (unfavourable) Mixed Tissue enhanced esophagus: 31.3 tonsil: 21.0 ASCL1 ASH1, bHLHa46, HASH1 ENSG00000139352 Achaete-scute family bHLH transcription factor 1 12 102957686-102960516 Predicted secreted proteins, Transcription factors Evidence at protein level HPA029217 Supported Group enriched Group enriched 8 cerebral cortex: 16.3;liver: 6.5 adrenal gland: 1.4 ASCL3 bHLHa42, HASH3, Sgn1 ENSG00000176009 Achaete-scute family bHLH transcription factor 3 11 8937579-8938211 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA027032 Uncertain Not detected Tissue enriched 9 salivary gland: 3.3 prostate,testis: 0.3 ASCL4 bHLHa44, HASH4 ENSG00000187855 Achaete-scute family bHLH transcription factor 4 12 107774385-107776644 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA036116 Uncertain Tissue enhanced Not detected parathyroid gland: 0.7 ATF1 TREB36 ENSG00000123268 Activating transcription factor 1 12 50763710-50821122 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB016222, HPA055069, HPA055406 Supported Validated Nucleoplasm Liver cancer:1.53e-5 (unfavourable) Expressed in all Expressed in all thyroid gland: 39.5 ATF2 CRE-BP1, CREB2, HB16, TREB7 ENSG00000115966 Activating transcription factor 2 2 175072250-175168382 Enzymes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB003769, HPA022134 Supported Validated Nucleoplasm Liver cancer:7.08e-5 (unfavourable) Expressed in all Expressed in all thyroid gland: 53.7 ATF3 ENSG00000162772 Activating transcription factor 3 1 212565334-212620777 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001562 Approved Validated Nucleus
Nucleoli Expressed in all Expressed in all smooth muscle: 445.6 ATF4 CREB-2, TAXREB67, TXREB ENSG00000128272 Activating transcription factor 4 22 39519695-39522685 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB011596 Approved Supported Microtubule organizing center
Cytosol Renal cancer:9.77e-5 (unfavourable), Liver cancer:4.07e-4 (unfavourable) Expressed in all Expressed in all bone marrow: 531.3 ATF5 ENSG00000169136 Activating transcription factor 5 19 49928702-49933935 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA030187 Uncertain Supported Nucleoplasm
Cytosol Renal cancer:3.39e-7 (unfavourable), Cervical cancer:1.14e-4 (favourable), Endometrial cancer:1.16e-4 (unfavourable) Tissue enriched Group enriched 7 liver: 387.7;thyroid gland: 190.1 appendix: 43.6 ATF6 ATF6A ENSG00000118217 Activating transcription factor 6 1 161766294-161964070 Plasma proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA005935 Approved Approved Cytosol Expressed in all Expressed in all parathyroid gland: 40.6 ATF6B CREBL1, G13 ENSG00000213676 Activating transcription factor 6 beta 6 32098176-32128253 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA046871 Uncertain Supported Nucleus
Nucleoli Expressed in all Expressed in all parathyroid gland: 55.8 ATF7 ATFA ENSG00000170653 Activating transcription factor 7 12 53507856-53626410 Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA003384 Approved Approved Nucleus
Cytosol Stomach cancer:2.10e-4 (unfavourable) Expressed in all Expressed in all endometrium: 40.1 ATOH7 bHLHa13, Math5 ENSG00000179774 Atonal bHLH transcription factor 7 10 68230624-68232103 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA027008 Uncertain Not detected Tissue enriched 6 cerebral cortex: 2.2 endometrium,kidney,small intestine: 0.3 ATOH8 bHLHa21, FLJ14708, HATH6 ENSG00000168874 Atonal bHLH transcription factor 8 2 85751344-85788066 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA028406 Supported Nucleoplasm Pancreatic cancer:8.98e-6 (favourable), Renal cancer:3.80e-5 (favourable) Tissue enhanced Tissue enhanced adipose tissue: 31.6 lung: 17.1 BACH1 BACH-1, BTBD24 ENSG00000156273 BTB and CNC homology 1, basic leucine zipper transcription factor 1 21 29194071-29630751 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA034949 Approved Nucleus
Cytosol Pancreatic cancer:3.11e-5 (unfavourable), Renal cancer:7.14e-4 (unfavourable) Expressed in all Expressed in all placenta: 71.6 BACH2 BTBD25 ENSG00000112182 BTB and CNC homology 1, basic leucine zipper transcription factor 2 6 89926529-90296908 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA051384, HPA058384 Supported Supported Nucleus
Cytosol Mixed Tissue enhanced lymph node: 21.4 tonsil: 12.5 BATF B-ATF, BATF1, SFA-2 ENSG00000156127 Basic leucine zipper transcription factor, ATF-like 14 75522425-75547015 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA059588, HPA064962 Approved Validated Nucleoplasm Renal cancer:3.74e-9 (unfavourable), Endometrial cancer:5.35e-6 (favourable), Head and neck cancer:7.91e-5 (favourable), Urothelial cancer:4.30e-4 (favourable), Colorectal cancer:8.30e-4 (unfavourable) Expressed in all Tissue enhanced lymph node: 31.9 appendix: 27.3 BATF2 MGC20410 ENSG00000168062 Basic leucine zipper transcription factor, ATF-like 2 11 64987943-64997045 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA062496 Approved Approved Nucleoli Ovarian cancer:9.39e-5 (favourable), Pancreatic cancer:2.12e-4 (unfavourable) Expressed in all Mixed spleen: 17.8 BHLHA15 bHLHa15, BHLHB8, MIST1 ENSG00000180535 Basic helix-loop-helix family, member a15 7 98211427-98212979 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB034083, HPA047834 Supported Approved Nucleoplasm
Golgi apparatus Tissue enhanced Group enriched 9 pancreas: 85.5;salivary gland: 54.2 prostate: 7.9 BHLHA9 bHLHa9, BHLHF42 ENSG00000205899 Basic helix-loop-helix family, member a9 17 1270559-1271460 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA062632 Uncertain Tissue enhanced Not detected cerebral cortex: 0.8 BHLHE22 Beta3, BHLHB5, bHLHe22, CAGL85, TNRC20 ENSG00000180828 Basic helix-loop-helix family, member e22 8 64580367-64583628 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA064128, HPA064872, HPA067500 Supported Mixed Tissue enhanced cerebral cortex: 12.2 seminal vesicle: 3.3 BHLHE23 bA305P22.3, Beta4, BHLHB4, bHLHe23 ENSG00000125533 Basic helix-loop-helix family, member e23 20 63005927-63007035 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA030575 Uncertain Tissue enriched Not detected testis: 0.1 BHLHE40 BHLHB2, bHLHe40, DEC1, STRA13 ENSG00000134107 Basic helix-loop-helix family, member e40 3 4979116-4985323 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA028922 Uncertain Supported Nuclear bodies Pancreatic cancer:8.74e-4 (unfavourable) Expressed in all Expressed in all esophagus: 230.8 BHLHE41 BHLHB3, bHLHe41, DEC2, SHARP-1, SHARP1 ENSG00000123095 Basic helix-loop-helix family, member e41 12 26120026-26125127 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA056035 Approved Nucleoplasm Renal cancer:8.73e-5 (unfavourable), Urothelial cancer:1.09e-4 (favourable) Expressed in all Tissue enhanced thyroid gland: 94.0 fallopian tube: 70.3 CEBPA C/EBP-alpha, CEBP ENSG00000245848 CCAAT/enhancer binding protein (C/EBP), alpha 19 33299934-33302564 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA052734, HPA065037, HPA067937 Approved Approved Nucleoplasm
Vesicles Expressed in all Expressed in all adipose tissue: 107.9 CEBPB C/EBP-beta, CRP2, IL6DBP, LAP, NFIL6, TCF5 ENSG00000172216 CCAAT/enhancer binding protein (C/EBP), beta 20 50190734-50192689 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004213, HPA061355, HPA062267 Supported Validated Nucleoplasm Renal cancer:2.44e-12 (unfavourable) Expressed in all Expressed in all adrenal gland: 112.9 CEBPD C/EBP-delta, CELF, CRP3, NF-IL6-beta ENSG00000221869 CCAAT/enhancer binding protein (C/EBP), delta 8 47736909-47739086 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA067581 Supported Nucleoplasm Renal cancer:2.87e-7 (unfavourable), Breast cancer:2.28e-5 (favourable) Expressed in all Expressed in all adipose tissue: 71.2 CEBPE CRP1 ENSG00000092067 CCAAT/enhancer binding protein (C/EBP), epsilon 14 23117304-23119616 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA002928, CAB005113 Supported Validated Nucleoplasm Not detected Tissue enriched 9 bone marrow: 26.0 small intestine: 2.8 CEBPG GPE1BP, IG/EBP-1 ENSG00000153879 CCAAT/enhancer binding protein (C/EBP), gamma 19 33373330-33382686 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA012024 Supported Supported Nucleoplasm Endometrial cancer:7.97e-5 (unfavourable), Renal cancer:7.23e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 41.2 CLOCK bHLHe8, KAT13D, KIAA0334 ENSG00000134852 Clock circadian regulator 4 55427903-55547138 Enzymes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001867, HPA027565 Supported Validated Nucleoplasm Expressed in all Mixed testis: 26.3 CREB1 ENSG00000118260 CAMP responsive element binding protein 1 2 207529737-207603431 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB003803, HPA019150 Supported Validated Nucleoplasm Liver cancer:2.77e-5 (unfavourable) Expressed in all Expressed in all testis: 58.7 CREB3 Luman, LZIP, sLZIP ENSG00000107175 CAMP responsive element binding protein 3 9 35732320-35737007 Predicted membrane proteins, Transcription factors Evidence at protein level HPA030978 Supported Cytosol Renal cancer:3.77e-5 (favourable), Ovarian cancer:5.40e-4 (favourable), Liver cancer:5.57e-4 (unfavourable) Expressed in all Expressed in all prostate: 54.5 CREB3L1 OASIS ENSG00000157613 CAMP responsive element binding protein 3-like 1 11 46277661-46321422 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA024069, CAB026151 Supported Uncertain Plasma membrane
Cytosol Renal cancer:2.97e-4 (unfavourable), Endometrial cancer:3.92e-4 (favourable), Thyroid cancer:8.59e-4 (unfavourable) Expressed in all Mixed stomach: 66.1 CREB3L2 BBF2H7, TCAG_1951439 ENSG00000182158 CAMP responsive element binding protein 3-like 2 7 137874979-138002067 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA015068, HPA015534 Uncertain Supported Nucleoplasm
Endoplasmic reticulum Expressed in all Expressed in all thyroid gland: 109.9 CREB3L3 CREB-H ENSG00000060566 CAMP responsive element binding protein 3-like 3 19 4153601-4173054 Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA040671, HPA056228 Supported Renal cancer:3.53e-6 (unfavourable) Tissue enriched Group enriched 104 duodenum: 248.3;liver: 61.3;small intestine: 284.6 colon: 1.9 CREB3L4 AIbZIP, ATCE1, CREB3, CREB4, hJAL ENSG00000143578 CAMP responsive element binding protein 3-like 4 1 153967534-153974363 Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA038122 Supported Approved Nucleoplasm
Nuclear membrane
Mitochondria Endometrial cancer:7.21e-4 (favourable) Group enriched Expressed in all prostate: 171.5 CREB5 CRE-BPA, H_GS165L15.1 ENSG00000146592 CAMP responsive element binding protein 5 7 28299321-28825894 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA050020, HPA061622 Approved Nucleus
Vesicles
Plasma membrane Mixed Mixed gallbladder: 18.6 CREBL2 ENSG00000111269 CAMP responsive element binding protein-like 2 12 12611827-12645108 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA043738 Uncertain Approved Nucleoplasm
Mitochondria
Cytosol Renal cancer:2.26e-5 (favourable) Expressed in all Expressed in all adrenal gland: 174.3 CREBZF ZF ENSG00000137504 CREB/ATF bZIP transcription factor 11 85659708-85682908 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA021526, HPA063652 Uncertain Approved Nucleus
Mitochondria Expressed in all Expressed in all endometrium,parathyroid gland: 31.1 CREM hCREM-2 ENSG00000095794 CAMP responsive element modulator 10 35126791-35212958 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001818, CAB018352 Supported Supported Nucleus
Vesicles Renal cancer:1.23e-5 (unfavourable) Expressed in all Expressed in all testis: 337.8 DDIT3 CHOP, CHOP10, GADD153 ENSG00000175197 DNA-damage-inducible transcript 3 12 57516588-57520517 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA058416, HPA068416 Approved Approved Nucleoplasm Liver cancer:6.55e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 263.1 EPAS1 bHLHe73, HIF2A, HLF, MOP2, PASD2 ENSG00000116016 Endothelial PAS domain protein 1 2 46293667-46386703 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA031200 Approved Nucleoplasm
Cytosol Renal cancer:2.63e-4 (favourable) Expressed in all Expressed in all placenta: 636.7 FERD3L bHLHa31, N-TWIST, NATO3 ENSG00000146618 Fer3-like bHLH transcription factor 7 19144782-19145421 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA043494 Uncertain Not detected Not detected cerebral cortex: 0.5 FOS AP-1, c-fos ENSG00000170345 FBJ murine osteosarcoma viral oncogene homolog 14 75278774-75282230 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA018531 Approved Supported Nucleoplasm Prostate cancer:7.81e-4 (favourable) Expressed in all Expressed in all fallopian tube: 1834.8 FOSB AP-1, DKFZp686C0818, G0S3, GOS3, GOSB, MGC42291 ENSG00000125740 FBJ murine osteosarcoma viral oncogene homolog B 19 45467995-45475179 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB010267, HPA054663 Approved Supported Nucleoplasm
Vesicles Expressed in all Mixed gallbladder: 560.0 FOSL1 fra-1 ENSG00000175592 FOS-like antigen 1 11 65892049-65900573 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004396, HPA066901 Uncertain Validated Nucleoplasm Renal cancer:6.40e-6 (unfavourable), Pancreatic cancer:9.26e-5 (unfavourable), Lung cancer:1.95e-4 (unfavourable), Head and neck cancer:2.05e-4 (unfavourable), Glioma:2.46e-4 (unfavourable) Expressed in all Tissue enhanced adipose tissue: 35.2;gallbladder: 51.8 urinary bladder: 27.7 FOSL2 FLJ23306, FRA2 ENSG00000075426 FOS-like antigen 2 2 28392448-28417312 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA004817, CAB013460, HPA061417 Supported Validated Nucleus Expressed in all Expressed in all adrenal gland: 226.0 HAND1 bHLHa27, eHand, Hxt, Thing1 ENSG00000113196 Heart and neural crest derivatives expressed 1 5 154474972-154478264 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA040925 Approved Uncertain Nucleus
Nuclear membrane Group enriched Tissue enhanced smooth muscle: 16.6 adrenal gland: 6.3 HAND2 bHLHa26, dHand, Hed, Thing2 ENSG00000164107 Heart and neural crest derivatives expressed 2 4 173524969-173530229 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA019591, CAB025576 Approved Supported Nucleoplasm
Vesicles Tissue enhanced Tissue enhanced endometrium: 83.7 smooth muscle: 77.6 HELT bHLHb44, HCM1228, HESL, MEGANE, Mgn ENSG00000187821 Helt bHLH transcription factor 4 185018841-185020804 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA036188, HPA036189 Uncertain Not detected Not detected lung: 0.5 HES1 bHLHb39, FLJ20408, HES-1, Hes1, HRY ENSG00000114315 Hes family bHLH transcription factor 1 3 194136145-194138732 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA050504 Supported Nucleoplasm Urothelial cancer:2.04e-5 (favourable) Expressed in all Mixed thyroid gland: 97.6 HES2 bHLHb40 ENSG00000069812 Hes family bHLH transcription factor 2 1 6412418-6424670 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA039462 Uncertain Mixed Tissue enhanced skin: 17.0 placenta: 9.8 HES3 bHLHb43 ENSG00000173673 Hes family bHLH transcription factor 3 1 6244192-6245578 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA047927, HPA072697 Uncertain Uncertain Nucleus Tissue enriched Not detected testis: 0.1 HES4 bHLHb42 ENSG00000188290 Hes family bHLH transcription factor 4 1 998962-1000172 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA062465 Approved Nucleoplasm
Vesicles
Cytosol Liver cancer:2.99e-4 (unfavourable), Endometrial cancer:3.85e-4 (favourable), Renal cancer:6.27e-4 (unfavourable) Expressed in all Mixed cerebral cortex: 7.5 HES5 bHLHb38 ENSG00000197921 Hes family bHLH transcription factor 5 1 2528745-2530245 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA065458 Approved Nucleoplasm
Nuclear speckles
Cytosol Tissue enhanced Tissue enhanced cerebral cortex: 1.8 skin: 0.9 HES6 bHLHb41 ENSG00000144485 Hes family bHLH transcription factor 6 2 238238267-238240662 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA061763 Approved Nucleus
Nucleoli
Nuclear bodies
Cytosol Lung cancer:9.18e-5 (favourable), Liver cancer:2.79e-4 (unfavourable) Expressed in all Tissue enhanced cerebral cortex: 77.0 fallopian tube: 22.1 HES7 bHLHb37 ENSG00000179111 Hes family bHLH transcription factor 7 17 8120590-8124092 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA072105 Uncertain Approved Nucleoplasm
Nucleoli Not detected Tissue enhanced placenta: 1.1 testis: 1.0 HEY1 bHLHb31, CHF-2, CHF2, HERP2, HESR-1, HESR1, HRT-1 ENSG00000164683 Hes-related family bHLH transcription factor with YRPW motif 1 8 79764010-79767863 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA055599, HPA063472 Uncertain Approved Nucleoplasm
Nuclear membrane
Cytosol Expressed in all Tissue enhanced cerebral cortex: 96.6 placenta: 28.7 HEY2 bHLHb32, HERP1, HESR2 ENSG00000135547 Hes-related family bHLH transcription factor with YRPW motif 2 6 125747664-125761269 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA030205, HPA074851 Approved Approved Nuclear bodies
Aggresome Expressed in all Mixed fallopian tube: 21.5 HEYL bHLHb33, HESR3, HEY3 ENSG00000163909 Hes-related family bHLH transcription factor with YRPW motif-like 1 39624153-39639945 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001438 Approved Mitochondria
Cytosol Renal cancer:2.26e-6 (unfavourable), Urothelial cancer:2.63e-5 (unfavourable), Stomach cancer:3.57e-4 (unfavourable) Expressed in all Mixed placenta: 44.0 HIF1A bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8 ENSG00000100644 Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 14 61695513-61748259 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA000907, HPA001275, CAB017442 Supported Supported Nucleoplasm
Nuclear bodies
Plasma membrane Expressed in all Expressed in all bone marrow: 292.9 HIF3A bHLHe17, IPAS, MOP7, PASD7 ENSG00000124440 Hypoxia inducible factor 3, alpha subunit 19 46297046-46343433 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA041141 Approved Supported Nucleoplasm
Plasma membrane
Cytosol Endometrial cancer:6.90e-9 (unfavourable) Mixed Tissue enhanced placenta: 39.5 spleen: 20.3 HLF MGC33822 ENSG00000108924 Hepatic leukemia factor 17 55265012-55325065 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA068156, HPA071210 Validated Nucleus Lung cancer:2.71e-7 (favourable), Renal cancer:3.55e-6 (favourable), Head and neck cancer:1.88e-4 (favourable) Tissue enhanced Mixed cerebral cortex: 65.6 ID1 bHLHb24, dJ857M17.1.2 ENSG00000125968 Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 20 31605283-31606515 Cancer-related genes, Plasma proteins, Predicted secreted proteins, Transcription factors Evidence at protein level CAB025915, HPA051456, HPA058518 Approved Validated Nucleoplasm
Golgi apparatus Lung cancer:4.85e-4 (unfavourable) Expressed in all Expressed in all seminal vesicle: 211.5 ID2 bHLHb26, GIG8 ENSG00000115738 Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2 8678845-8684453 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA027612 Approved Nucleoplasm
Nuclear bodies
Centrosome Head and neck cancer:9.95e-4 (favourable) Expressed in all Tissue enriched 5 parathyroid gland: 1947.2 thyroid gland: 357.9 ID3 bHLHb25, HEIR-1 ENSG00000117318 Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1 23557918-23559794 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB021353, HPA024677 Approved Supported Nucleoplasm Endometrial cancer:1.27e-5 (favourable) Expressed in all Mixed seminal vesicle: 90.6 ID4 bHLHb27 ENSG00000172201 Inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 6 19837386-19840684 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA060800 Supported Nucleus Pancreatic cancer:2.49e-4 (favourable) Expressed in all Tissue enhanced thyroid gland: 623.1 fallopian tube: 127.6 JDP2 JUNDM2 ENSG00000140044 Jun dimerization protein 2 14 75427716-75474111 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA059511 Supported Approved Nucleoplasm
Nuclear speckles Colorectal cancer:8.58e-5 (unfavourable) Expressed in all Expressed in all spleen: 87.3 JUN AP-1, c-Jun ENSG00000177606 Jun proto-oncogene 1 58780788-58784327 Cancer-related genes, FDA approved drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB003801, CAB007780, HPA059474 Supported Validated Nucleoplasm Expressed in all Expressed in all thyroid gland: 312.9 JUNB ENSG00000171223 Jun B proto-oncogene 19 12791496-12793315 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB004464, HPA019149 Approved Validated Nucleoplasm Renal cancer:1.05e-4 (unfavourable), Ovarian cancer:3.65e-4 (unfavourable) Expressed in all Expressed in all adrenal gland: 322.6 JUND AP-1 ENSG00000130522 Jun D proto-oncogene 19 18279760-18281622 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB005268, HPA063029 Supported Supported Nucleus Breast cancer:6.15e-5 (favourable) Expressed in all Expressed in all bone marrow: 278.3 LYL1 bHLHa18 ENSG00000104903 Lymphoblastic leukemia associated hematopoiesis regulator 1 19 13099033-13103161 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA075004 Approved Golgi apparatus Renal cancer:3.89e-4 (unfavourable) Expressed in all Tissue enhanced bone marrow: 22.9;spleen: 21.2 appendix: 14.8 MAF c-MAF ENSG00000178573 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 16 79585843-79600714 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB010296, HPA028289 Approved Renal cancer:3.74e-4 (unfavourable) Expressed in all Tissue enhanced parathyroid gland: 147.2 small intestine: 93.1 MAFB KRML ENSG00000204103 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 20 40685848-40689240 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA005653 Approved Approved Nucleus
Nucleoli Endometrial cancer:5.64e-4 (unfavourable) Expressed in all Tissue enriched 7 parathyroid gland: 677.4 spleen: 103.7 MAFF hMafF ENSG00000185022 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 22 38200767-38216511 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB025341, HPA055371 Approved Approved Nucleus
Mitochondria Breast cancer:4.32e-4 (favourable) Expressed in all Mixed gallbladder: 66.4 MAFG MGC13090, MGC20149 ENSG00000197063 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 17 81918270-81927714 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB025573 Approved Liver cancer:1.90e-6 (unfavourable), Endometrial cancer:5.82e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 28.3 MAFK NFE2U, P18 ENSG00000198517 V-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 7 1530714-1543043 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB026820, HPA060841 Approved Validated Nucleoplasm Expressed in all Expressed in all placenta: 36.6 MAX bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 ENSG00000125952 MYC associated factor X 14 65006174-65102695 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000328, HPA003474 Supported Supported Nucleoplasm
Golgi apparatus
Vesicles Thyroid cancer:2.12e-4 (favourable), Renal cancer:5.57e-4 (unfavourable) Expressed in all Expressed in all spleen: 80.2 MESP1 bHLHc5, MGC10676 ENSG00000166823 Mesoderm posterior bHLH transcription factor 1 15 89748661-89751310 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA069981 Supported Nucleus
Nucleoli Group enriched Tissue enhanced adipose tissue: 4.8;prostate: 4.0 cerebral cortex: 1.4 MGA FLJ12634, KIAA0518, MAD5, MXD5 ENSG00000174197 MGA, MAX dimerization protein 15 41621224-41773081 Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA042278, HPA058183 Approved Supported Nucleoplasm
Cytosol Expressed in all Expressed in all testis: 16.0 MITF bHLHe32, MI, WS2, WS2A ENSG00000187098 Microphthalmia-associated transcription factor 3 69739435-69968337 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB002578, HPA003259 Supported Renal cancer:8.35e-10 (favourable) Group enriched Tissue enhanced cervix, uterine: 80.4;endometrium: 78.8 smooth muscle: 68.6 MLX bHLHd13, MAD7, MXD7, TCFL4 ENSG00000108788 MLX, MAX dimerization protein 17 42567068-42573239 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB025329, HPA052766, HPA064438 Approved Approved Nucleoplasm
Nuclear membrane
Cytosol Expressed in all Expressed in all duodenum: 47.6 MLXIP bHLHe36, KIAA0867, MIR, MONDOA ENSG00000175727 MLX interacting protein 12 122078722-122147347 Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA023084 Approved Liver cancer:2.28e-4 (unfavourable), Renal cancer:2.92e-4 (unfavourable) Expressed in all Expressed in all rectum: 24.8 MLXIPL bHLHd14, CHREBP, MIO, MONDOB, WBSCR14, WS-bHLH ENSG00000009950 MLX interacting protein-like 7 73593194-73624543 Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA064640 Supported Nucleus Tissue enriched Tissue enhanced adipose tissue: 60.8;duodenum: 60.3 liver: 47.2 MNT bHLHd3, MAD6, MXD6, ROX ENSG00000070444 MAX network transcriptional repressor 17 2384060-2401118 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA059532, HPA067578 Validated Nucleoplasm Expressed in all Expressed in all cerebral cortex: 15.3 MSC ABF-1, bHLHa22 ENSG00000178860 Musculin 8 71841549-71844468 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA062878 Supported Nucleoplasm Renal cancer:1.07e-13 (unfavourable), Liver cancer:4.83e-5 (unfavourable), Glioma:7.15e-4 (unfavourable) Expressed in all Mixed placenta: 22.6 MXD1 bHLHc58, MAD, MAD1 ENSG00000059728 MAX dimerization protein 1 2 69897688-69942945 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001599 Supported Uncertain Nucleoplasm
Mitochondria
Cytosol Endometrial cancer:8.14e-6 (unfavourable), Pancreatic cancer:8.50e-4 (unfavourable) Expressed in all Tissue enhanced bone marrow: 114.0;esophagus: 102.3 appendix: 57.5 MXD3 bHLHc13, MAD3 ENSG00000213347 MAX dimerization protein 3 5 177301461-177312757 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA070111 Approved Nucleus
Nucleoli Liver cancer:3.60e-4 (unfavourable) Expressed in all Tissue enhanced bone marrow: 24.3 skin: 12.6 MXD4 bHLHc12, MAD4, MST149, MSTP149 ENSG00000123933 MAX dimerization protein 4 4 2247432-2262294 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA053363 Supported Cytosol Pancreatic cancer:1.39e-5 (favourable), Head and neck cancer:2.21e-5 (favourable) Expressed in all Expressed in all spleen: 42.0 MXI1 bHLHc11, MAD2, MXD2, MXI ENSG00000119950 MAX interactor 1, dimerization protein 10 110207605-110287365 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA035319, HPA056762 Approved Supported Nucleus
Nucleoli Renal cancer:1.02e-5 (unfavourable), Prostate cancer:9.17e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 88.4 MYC bHLHe39, c-Myc, MYCC ENSG00000136997 V-myc avian myelocytomatosis viral oncogene homolog 8 127735434-127741434 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000084, CAB010307, HPA055893, HPA066556 Supported Validated Nucleoplasm Renal cancer:5.49e-8 (unfavourable), Urothelial cancer:4.96e-5 (unfavourable), Ovarian cancer:7.52e-4 (unfavourable) Expressed in all Expressed in all adipose tissue: 144.4 MYCL bHLHe38, LMYC, MYCL1 ENSG00000116990 V-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 1 39895426-39902256 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA063132 Supported Nucleus Lung cancer:4.49e-4 (favourable) Expressed in all Tissue enhanced skin: 41.7 urinary bladder: 24.6 MYCN bHLHe37, MYCNOT, N-myc, NMYC ENSG00000134323 V-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 2 15940564-15947007 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA057420 Approved Nucleus
Nucleoli Tissue enhanced Tissue enhanced placenta: 9.6 cerebral cortex: 5.3 MYF5 bHLHc2 ENSG00000111049 Myogenic factor 5 12 80716912-80719673 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA041691 Supported Nucleoplasm Not detected Tissue enhanced skeletal muscle: 1.9 esophagus,prostate: 0.3 MYOD1 bHLHc1, MYF3, MYOD, PUM ENSG00000129152 Myogenic differentiation 1 11 17719568-17722131 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA051362 Supported Nucleoplasm
Nuclear bodies
Cytosol Tissue enhanced Tissue enriched 12 skeletal muscle: 9.0 prostate: 0.7 MYOG bHLHc3, MYF4 ENSG00000122180 Myogenin (myogenic factor 4) 1 203083132-203086036 Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA028336, HPA038093 Approved Supported Nucleoplasm Group enriched Tissue enriched 12 skeletal muscle: 31.7 prostate: 2.7 NCOA1 bHLHe74, F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1 ENSG00000084676 Nuclear receptor coactivator 1 2 24491914-24770702 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB019402, HPA070213, HPA070520 Supported Validated Nucleoplasm
Plasma membrane
Cytosol Expressed in all Expressed in all parathyroid gland: 58.0 NCOA2 bHLHe75, GRIP1, KAT13C, NCoA-2, TIF2 ENSG00000140396 Nuclear receptor coactivator 2 8 70109762-70403805 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA060243 Supported Nucleoplasm
Nuclear bodies Renal cancer:5.08e-4 (favourable) Expressed in all Expressed in all epididymis: 35.4 NCOA3 ACTR, AIB1, bHLHe42, CAGH16, KAT13B, p/CIP, RAC3, SRC-3, SRC3, TNRC16, TRAM-1 ENSG00000124151 Nuclear receptor coactivator 3 20 47501902-47656877 Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB009800, HPA024210 Supported Supported Nucleoplasm
Cytosol Liver cancer:8.09e-4 (unfavourable) Expressed in all Expressed in all lymph node: 45.3 NEUROD1 BETA2, BHF-1, bHLHa3, MODY6, NEUROD ENSG00000162992 Neuronal differentiation 1 2 181673088-181680876 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003278, CAB022450 Approved Glioma:6.83e-5 (favourable) Tissue enhanced Tissue enhanced cerebral cortex: 6.0;duodenum: 6.2;small intestine: 4.5;stomach: 4.9 pancreas: 1.8 NEUROD4 ATH-3, Atoh3, bHLHa4, MATH-3 ENSG00000123307 Neuronal differentiation 4 12 55019945-55030014 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA015545 Supported Not detected Tissue enhanced adrenal gland: 2.3;testis: 1.0 cerebral cortex: 0.4 NEUROD6 Atoh2, bHLHa2, Math-2, Nex1, NEX1M ENSG00000164600 Neuronal differentiation 6 7 31337461-31340894 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA027046 Approved Not detected Tissue enriched 225 cerebral cortex: 22.4 all non-specific tissues: 0.0 NEUROG2 Atoh4, bHLHa8, Math4A, ngn-2, NGN2 ENSG00000178403 Neurogenin 2 4 112513516-112516172 Predicted intracellular proteins, Transcription factors Evidence at transcript level CAB012342 Uncertain Tissue enhanced Tissue enhanced testis: 1.5 cerebral cortex: 0.4 NEUROG3 Atoh5, bHLHa7, Math4B, ngn3 ENSG00000122859 Neurogenin 3 10 69571698-69573238 Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA039785 Uncertain Tissue enhanced Tissue enhanced duodenum: 2.9;small intestine: 1.3 colon,rectum: 0.4 NFE2 NF-E2 ENSG00000123405 Nuclear factor, erythroid 2 12 54292111-54301121 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001914 Approved Mixed Tissue enriched 6 bone marrow: 68.7 spleen: 12.1 NFE2L1 FLJ00380, LCR-F1, NRF1, TCF11 ENSG00000082641 Nuclear factor, erythroid 2-like 1 17 48048329-48061487 Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA063384, HPA065424 Approved Approved Nucleus
Cytosol Renal cancer:5.79e-6 (favourable), Endometrial cancer:8.20e-5 (favourable), Head and neck cancer:2.73e-4 (unfavourable) Expressed in all Expressed in all skeletal muscle: 468.1 NFE2L2 NRF2 ENSG00000116044 Nuclear factor, erythroid 2-like 2 2 177227595-177392697 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA002990, CAB020317, HPA043438 Supported Approved Nucleus
Plasma membrane
Cytosol Renal cancer:2.26e-4 (favourable) Expressed in all Expressed in all esophagus: 267.9 NFE2L3 Nrf3 ENSG00000050344 Nuclear factor, erythroid 2-like 3 7 26152240-26187125 Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA055889 Supported Approved Nucleoplasm
Vesicles Renal cancer:7.58e-12 (unfavourable), Pancreatic cancer:6.62e-5 (unfavourable), Stomach cancer:2.14e-4 (favourable) Expressed in all Tissue enhanced placenta: 51.1 appendix: 14.8 NFIL3 E4BP4, IL3BP1, NF-IL3A, NFIL3A ENSG00000165030 Nuclear factor, interleukin 3 regulated 9 91409045-91423862 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003261 Approved Approved Nuclear bodies Renal cancer:3.23e-6 (unfavourable) Expressed in all Expressed in all bone marrow: 137.4 NHLH1 bHLHa35, HEN1, NSCL, NSCL1 ENSG00000171786 Nescient helix loop helix 1 1 160367067-160372848 Predicted intracellular proteins, Transcription factors Evidence at transcript level CAB033854 Uncertain Group enriched Not detected skin: 0.8 NHLH2 bHLHa34, HEN2, NSCL2 ENSG00000177551 Nescient helix loop helix 2 1 115836377-115843917 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA055238 Uncertain Approved Nucleoplasm
Nuclear bodies Not detected Tissue enhanced skin: 3.9 cerebral cortex,testis: 0.8 NPAS1 bHLHe11, MOP5, PASD5 ENSG00000130751 Neuronal PAS domain protein 1 19 47019820-47045775 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA043364, HPA072259 Approved Approved Nucleoplasm Tissue enhanced Group enriched 5 cerebral cortex: 3.9;skin: 4.4;spleen: 1.9;stomach: 2.7 lymph node: 0.6 NPAS2 bHLHe9, MOP4, PASD4 ENSG00000170485 Neuronal PAS domain protein 2 2 100820152-100996829 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA019674 Uncertain Supported Approved Nucleoplasm Renal cancer:3.55e-7 (unfavourable), Liver cancer:2.07e-4 (unfavourable) Expressed in all Mixed esophagus: 27.5 NPAS3 bHLHe12, MOP6, PASD6 ENSG00000151322 Neuronal PAS domain protein 3 14 32934933-33804176 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA002892 Approved Approved Nucleoplasm Tissue enhanced Tissue enhanced cerebral cortex: 25.0 cervix, uterine: 10.0 NPAS4 bHLHe79, Le-PAS, NXF, PASD10 ENSG00000174576 Neuronal PAS domain protein 4 11 66421004-66426707 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA039255 Uncertain Not detected Tissue enhanced cerebral cortex: 4.1;endometrium: 1.9 smooth muscle: 1.5 NRL D14S46E, NRL-MAF, RP27 ENSG00000129535 Neural retina leucine zipper 14 24080107-24115014 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB026066, HPA064599 Supported Supported Nucleoplasm
Cytosol Mixed Mixed parathyroid gland: 4.1 OLIG2 BHLHB1, bHLHe19, OLIGO2, PRKCBP2, RACK17 ENSG00000205927 Oligodendrocyte lineage transcription factor 2 21 33025845-33029196 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003254, CAB019381 Supported Uncertain Nucleoplasm
Plasma membrane Tissue enriched Tissue enriched 239 cerebral cortex: 91.2 duodenum: 0.3 OLIG3 Bhlhb7, bHLHe20 ENSG00000177468 Oligodendrocyte transcription factor 3 6 137492202-137494250 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA018303, CAB024865 Uncertain Not detected Not detected esophagus: 0.1 PTF1A bHLHa29, PTF1-p48 ENSG00000168267 Pancreas specific transcription factor, 1a 10 23192327-23194252 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB022612 Approved Nucleoplasm Tissue enhanced Tissue enriched 6 pancreas: 7.7 testis: 1.2 SCX bHLHa41, bHLHa48, SCXA, SCXB ENSG00000260428 Scleraxis bHLH transcription factor 8 144266560-144268481 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA043183 Uncertain Glioma:2.46e-4 (unfavourable) Group enriched Tissue enhanced skeletal muscle: 5.3 parathyroid gland: 3.3 SIM1 bHLHe14 ENSG00000112246 Single-minded family bHLH transcription factor 1 6 100385015-100464929 Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA024385 Approved Nuclear speckles Renal cancer:5.32e-7 (favourable) Tissue enhanced Tissue enhanced epididymis: 3.4;kidney: 11.1;seminal vesicle: 3.1 skeletal muscle: 1.2 SIM2 bHLHe15, MGC119447, SIM ENSG00000159263 Single-minded family bHLH transcription factor 2 21 36699133-36749917 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA029295 Approved Supported Nucleoplasm
Nuclear bodies Endometrial cancer:2.10e-4 (unfavourable), Urothelial cancer:2.88e-4 (favourable) Tissue enhanced Tissue enhanced esophagus: 22.9;kidney: 13.0 prostate: 9.1 SOHLH1 bA100C15.3, bHLHe80, C9orf157, NOHLH, SPATA27, TEB2 ENSG00000165643 Spermatogenesis and oogenesis specific basic helix-loop-helix 1 9 135693407-135699528 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA059439 Approved Nuclear speckles Mixed Group enriched 27 cerebral cortex: 6.4;testis: 13.4 skin: 0.3 SOHLH2 bHLHe81, FLJ20449, SPATA28, TEB1 ENSG00000120669 Spermatogenesis and oogenesis specific basic helix-loop-helix 2 13 36168208-36214615 Predicted intracellular proteins, Transcription factors Evidence at transcript level HPA029182, HPA029183 Uncertain Vesicles Mixed Tissue enriched 13 testis: 46.0 prostate: 3.5 SREBF1 bHLHd1, SREBP-1c, SREBP1 ENSG00000072310 Sterol regulatory element binding transcription factor 1 17 17810399-17837002 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level CAB005406, HPA043343, HPA043878 Uncertain Supported Golgi apparatus
Cytosol Endometrial cancer:2.66e-4 (favourable), Pancreatic cancer:9.05e-4 (favourable) Expressed in all Expressed in all adrenal gland: 92.9 SREBF2 bHLHd2, SREBP2 ENSG00000198911 Sterol regulatory element binding transcription factor 2 22 41833079-41907308 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transcription factors Evidence at protein level HPA031962, HPA031963 Approved Supported Nucleoplasm
Vesicles
Mitochondria Renal cancer:1.37e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 118.8 TAL1 bHLHa17, SCL, TCL5 ENSG00000162367 T-cell acute lymphocytic leukemia 1 1 47216290-47232220 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB017805, HPA047866 Approved Approved Nucleus Mixed Tissue enhanced bone marrow: 17.7 placenta: 10.0 TAL2 bHLHa19 ENSG00000186051 T-cell acute lymphocytic leukemia 2 9 105662457-105663112 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA030886 Uncertain Approved Cytosol Renal cancer:2.69e-4 (favourable) Tissue enhanced Group enriched 5 kidney: 3.4;skeletal muscle: 4.8 epididymis: 0.8 TCF12 bHLHb20, HEB, HsT17266, HTF4 ENSG00000140262 Transcription factor 12 15 56918623-57299281 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level CAB004432, HPA065827 Approved Supported Nucleoplasm
Nuclear speckles Renal cancer:5.24e-5 (unfavourable), Melanoma:8.89e-4 (unfavourable) Expressed in all Expressed in all cervix, uterine: 115.4 TCF15 bHLHa40, EC2, PARAXIS ENSG00000125878 Transcription factor 15 (basic helix-loop-helix) 20 603797-610398 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA050998, HPA060221 Uncertain Supported Nuclear speckles Ovarian cancer:3.25e-4 (unfavourable) Mixed Group enriched 5 adipose tissue: 9.0;heart muscle: 5.5;placenta: 8.0;skeletal muscle: 7.2;testis: 2.2 lung: 1.2 TCF21 bHLHa23, POD1 ENSG00000118526 Transcription factor 21 6 133889138-133895553 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA013189 Uncertain Mixed Tissue enhanced placenta: 62.1;spleen: 47.8 ovary: 32.1 TCF3 bHLHb21, E2A, E47, ITF1, MGC129647, MGC129648, VDIR ENSG00000071564 Transcription factor 3 19 1609290-1652605 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB018351, HPA049808, HPA062476 Approved Validated Nucleoplasm Renal cancer:1.53e-4 (unfavourable), Liver cancer:2.46e-4 (unfavourable) Expressed in all Expressed in all lymph node: 104.6 TCF4 bHLHb19, E2-2, ITF2, SEF2-1B ENSG00000196628 Transcription factor 4 18 55222331-55664787 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB020722, HPA025958 Approved Approved Nucleoplasm
Cytosol Renal cancer:7.24e-5 (unfavourable), Urothelial cancer:9.95e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 90.8 TCFL5 bHLHe82, CHA, E2BP-1, Figlb ENSG00000101190 Transcription factor-like 5 (basic helix-loop-helix) 20 62841115-62861763 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA055223 Approved Supported Nucleoplasm Endometrial cancer:3.24e-4 (unfavourable) Expressed in all Expressed in all testis: 143.8 TFAP2A AP-2, AP2TF, TFAP2 ENSG00000137203 Transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 6 10393186-10419659 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000326, HPA028850, HPA056871 Supported Validated Nucleoplasm Lung cancer:1.09e-4 (unfavourable) Tissue enhanced Tissue enhanced breast: 39.8;placenta: 42.1;skin: 76.2 epididymis: 25.2 TFAP2B AP2-B ENSG00000008196 Transcription factor AP-2 beta (activating enhancer binding protein 2 beta) 6 50818723-50847613 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA034683, HPA062942 Approved Approved Nucleoplasm Tissue enriched Tissue enhanced epididymis: 38.7 breast: 9.5 TFAP2C AP2-GAMMA, ERF1, hAP-2g, TFAP2G ENSG00000087510 Transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 20 56629302-56639283 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB016061, CAB016079, HPA055179, HPA057076 Supported Supported Nucleoplasm Cervical cancer:6.90e-4 (favourable) Tissue enhanced Tissue enhanced skin: 63.1 breast: 31.6 TFAP2D TFAP2BL1 ENSG00000008197 Transcription factor AP-2 delta (activating enhancer binding protein 2 delta) 6 50713828-50772988 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA048962 Uncertain Tissue enriched Not detected cerebral cortex,testis: 0.1 TFAP4 AP-4, bHLHc41 ENSG00000090447 Transcription factor AP-4 (activating enhancer binding protein 4) 16 4257186-4273075 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001912 Supported Supported Nucleoplasm
Mitochondria Renal cancer:4.31e-6 (unfavourable), Liver cancer:3.32e-4 (unfavourable) Expressed in all Mixed ovary: 12.0 TFE3 bHLHe33, TFEA ENSG00000068323 Transcription factor binding to IGHM enhancer 3 X 49028726-49043486 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA023881 Approved Supported Nucleoplasm
Cytosol Renal cancer:2.19e-8 (unfavourable), Liver cancer:6.03e-5 (unfavourable) Expressed in all Expressed in all seminal vesicle: 24.2 TFEB bHLHe35, TCFEB ENSG00000112561 Transcription factor EB 6 41683978-41736259 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA049532 Supported Nucleoplasm Renal cancer:1.06e-5 (favourable), Pancreatic cancer:4.77e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 53.4 TFEC bHLHe34, TCFEC, TFECL ENSG00000105967 Transcription factor EC 7 115935148-116159896 Predicted intracellular proteins, Transcription factors Evidence at protein level CAB032260, HPA063577 Approved Supported Nucleoplasm Tissue enhanced Mixed appendix: 27.1 TSC22D1 MGC17597, TGFB1I4, TSC22 ENSG00000102804 TSC22 domain family, member 1 13 44432143-44577147 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA077414 Approved Nucleoplasm
Nuclear bodies Renal cancer:4.54e-4 (favourable), Ovarian cancer:7.97e-4 (unfavourable) Expressed in all Expressed in all prostate: 263.0 TSC22D2 KIAA0669, TILZ4a, TILZ4b, TILZ4c ENSG00000196428 TSC22 domain family, member 2 3 150408335-150466431 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA004926 Approved Approved Cytosol Endometrial cancer:2.74e-4 (unfavourable), Renal cancer:5.80e-4 (unfavourable) Expressed in all Expressed in all endometrium: 37.8 TSC22D3 DIP, DSIPI, GILZ, hDIP, TSC-22R ENSG00000157514 TSC22 domain family, member 3 X 107713221-107777342 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001916 Approved Nuclear speckles
Golgi apparatus
Cytosol Endometrial cancer:2.43e-4 (unfavourable) Expressed in all Expressed in all appendix: 554.1 TSC22D4 THG-1, TILZ2 ENSG00000166925 TSC22 domain family, member 4 7 100463359-100479279 Predicted intracellular proteins, Predicted secreted proteins, Transcription factors Evidence at protein level HPA006757 Uncertain Approved Cytosol Colorectal cancer:2.66e-4 (unfavourable), Liver cancer:9.45e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 278.9 TWIST2 bHLHa39, Dermo-1, DERMO1 ENSG00000233608 Twist family bHLH transcription factor 2 2 238848032-238910543 Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA062870 Supported Nucleus
Nucleoli Mixed Tissue enhanced cervix, uterine: 40.2 adipose tissue: 27.3 USF1 bHLHb11, MLTFI, UEF ENSG00000158773 Upstream transcription factor 1 1 161039251-161045977 Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB001480, HPA036233, HPA036535 Supported Validated Nucleoplasm Renal cancer:6.01e-12 (unfavourable), Urothelial cancer:1.95e-5 (favourable), Head and neck cancer:8.70e-4 (favourable) Expressed in all Expressed in all spleen: 35.5 USF2 bHLHb12, FIP ENSG00000105698 Upstream transcription factor 2, c-fos interacting 19 35268978-35279821 Predicted intracellular proteins, Transcription factors Evidence at protein level HPA029764, HPA046567 Supported Nucleoplasm
Vesicles Pancreatic cancer:5.12e-5 (favourable), Urothelial cancer:3.28e-4 (favourable) Expressed in all Expressed in all cerebral cortex: 216.0