Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific ALK CD246 ENSG00000171094 Anaplastic lymphoma receptor tyrosine kinase 2 29192774-29921566 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010694 Approved Supported Plasma membrane Group enriched Tissue enhanced cerebral cortex: 3.5;testis: 2.3 adrenal gland: 0.9 APC DP2, DP2.5, DP3, PPP1R46 ENSG00000134982 Adenomatous polyposis coli 5 112707498-112846239 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA013349, CAB025994 Approved Expressed in all Tissue enhanced cerebral cortex: 60.3 parathyroid gland: 19.5 ATM ATA, ATC, ATD, ATDC, TEL1, TELO1 ENSG00000149311 ATM serine/threonine kinase 11 108222484-108369102 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB000102, HPA067142 Supported Supported Nucleoplasm Expressed in all Expressed in all lymph node: 41.6 ATR FRP1, MEC1, SCKL, SCKL1 ENSG00000175054 ATR serine/threonine kinase 3 142449235-142578826 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA054320 Supported Nucleoplasm
Golgi apparatus Pancreatic cancer:1.23e-5 (unfavourable), Liver cancer:8.39e-5 (unfavourable) Expressed in all Mixed parathyroid gland: 15.2 AXIN2 DKFZp781B0869, MGC126582 ENSG00000168646 Axin 2 17 65528563-65561647 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB012283, CAB017783 Approved Uncertain Nucleus
Plasma membrane
Cytosol Pancreatic cancer:6.58e-4 (favourable) Expressed in all Mixed endometrium: 31.0 BAP1 hucep-6, KIAA0272, UCHL2 ENSG00000163930 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) 3 52401013-52410350 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004322, HPA028814, HPA028815, HPA055560 Approved Validated Nucleoplasm
Cytosol Renal cancer:3.29e-7 (favourable) Expressed in all Expressed in all testis: 118.1 BLM BS, RECQ2, RECQL3 ENSG00000197299 Bloom syndrome, RecQ helicase-like 15 90717327-90816165 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA005689 Approved Supported Nucleus
Cytosol Mixed Mixed lymph node: 3.8 BMPR1A ACVRLK3, ALK3, CD292 ENSG00000107779 Bone morphogenetic protein receptor, type IA 10 86756650-86932838 Cancer-related genes, CD markers, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB019398 Approved Approved Cytosol Liver cancer:8.93e-4 (unfavourable), Glioma:9.38e-4 (favourable) Expressed in all Mixed thyroid gland: 33.8 BRCA1 BRCC1, FANCS, PPP1R53, RNF53 ENSG00000012048 Breast cancer 1, early onset 17 43044295-43170245 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB001946, HPA034966 Approved Expressed in all Mixed testis: 23.9 BRCA2 BRCC2, FACD, FAD, FAD1, FANCD, FANCD1, XRCC11 ENSG00000139618 Breast cancer 2, early onset 13 32315474-32400266 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA026815 Uncertain Approved Nucleoplasm
Cytosol Mixed Tissue enhanced testis: 5.1 bone marrow: 4.1 BRIP1 BACH1, FANCJ, OF ENSG00000136492 BRCA1 interacting protein C-terminal helicase 1 17 61681266-61863521 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA005474 Approved Supported Nucleus
Nuclear membrane Colorectal cancer:3.45e-5 (favourable), Head and neck cancer:3.62e-4 (favourable) Mixed Tissue enhanced testis: 14.4 bone marrow: 5.0 BUB1B Bub1A, BUBR1, MAD3L, SSK1 ENSG00000156970 BUB1 mitotic checkpoint serine/threonine kinase B 15 40161023-40221136 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA008419 Supported Cytosol Liver cancer:7.43e-6 (unfavourable), Pancreatic cancer:1.79e-4 (unfavourable), Lung cancer:3.56e-4 (unfavourable) Expressed in all Tissue enhanced testis: 40.2 lymph node: 15.1 CDC73 C1orf28, FIHP, HRPT1, HRPT2, parafibromin ENSG00000134371 Cell division cycle 73 1 193122017-193253901 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB016359, HPA030772 Supported Supported Nucleus
Cytosol Expressed in all Expressed in all thyroid gland: 32.0 CDH1 CD324, UVO, uvomorulin ENSG00000039068 Cadherin 1, type 1 16 68737225-68835548 Cancer-related genes, CD markers, Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000087, HPA004812, CAB028364, CAB072855, CAB072856, CAB072857 Supported Supported Golgi apparatus
Plasma membrane
Cell Junctions Renal cancer:2.06e-4 (favourable) Expressed in all Tissue enhanced parathyroid gland: 467.0 thyroid gland: 264.7 CDK4 PSK-J3 ENSG00000135446 Cyclin-dependent kinase 4 12 57747727-57756013 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA006024, CAB069405 Approved Supported Nucleus
Nuclear membrane
Nucleoli
Cytosol Liver cancer:2.09e-7 (unfavourable), Renal cancer:3.15e-5 (unfavourable) Expressed in all Expressed in all endometrium: 120.2 CDKN1B KIP1, P27KIP1 ENSG00000111276 Cyclin-dependent kinase inhibitor 1B (p27, Kip1) 12 12715058-12722371 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB003691, CAB021888, HPA059086 Approved Supported Nucleus
Vesicles Liver cancer:3.25e-4 (unfavourable), Colorectal cancer:5.15e-4 (favourable), Renal cancer:8.39e-4 (unfavourable) Expressed in all Expressed in all ovary: 72.9 CDKN2A ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf ENSG00000147889 Cyclin-dependent kinase inhibitor 2A 9 21967753-21995301 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB000093, CAB000445, CAB018232, HPA047838 Uncertain Validated Nucleoli Endometrial cancer:1.82e-7 (unfavourable), Renal cancer:5.76e-7 (unfavourable), Liver cancer:2.17e-4 (unfavourable), Head and neck cancer:5.19e-4 (favourable) Expressed in all Mixed parathyroid gland: 7.5 CHEK2 bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53 ENSG00000183765 Checkpoint kinase 2 22 28687743-28742422 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA001878, CAB002030 Approved Supported Nucleoplasm
Golgi apparatus Renal cancer:7.80e-9 (unfavourable) Expressed in all Mixed testis: 13.2 CYLD CYLD1, KIAA0849, USPL2 ENSG00000083799 Cylindromatosis (turban tumor syndrome) 16 50742050-50801935 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB011713, HPA050095 Approved Supported Nucleoplasm
Microtubule organizing center Expressed in all Expressed in all testis: 70.2 DDB2 DDBB, FLJ34321, UV-DDB2, XPE ENSG00000134574 Damage-specific DNA binding protein 2, 48kDa 11 47214465-47239240 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB025912, HPA058406 Supported Supported Nucleoplasm
Cell Junctions Endometrial cancer:1.20e-4 (favourable), Cervical cancer:1.58e-4 (favourable), Breast cancer:7.29e-4 (favourable) Expressed in all Expressed in all skin: 53.8 DICER1 Dicer, HERNA, K12H4.8-LIKE, KIAA0928, MNG1 ENSG00000100697 Dicer 1, ribonuclease type III 14 95086228-95158010 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA000694, CAB068185 Approved Supported Cytosol Expressed in all Expressed in all placenta: 32.2 EGFR ERBB, ERBB1 ENSG00000146648 Epidermal growth factor receptor 7 55019021-55256620 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level CAB000035, HPA001200, HPA018530, CAB068186, CAB073534 Supported Validated Plasma membrane Urothelial cancer:2.04e-5 (unfavourable) Expressed in all Tissue enhanced placenta: 97.3 skin: 58.9 ERCC2 EM9, MAG, MGC102762, MGC126218, MGC126219, TFIIH, XPD ENSG00000104884 Excision repair cross-complementation group 2 19 45349837-45370918 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB005375, HPA038057, HPA069266 Approved Supported Nucleoplasm Pancreatic cancer:3.26e-4 (favourable) Expressed in all Expressed in all testis: 16.2 ERCC3 BTF2, GTF2H, RAD25, TFIIH, XPB ENSG00000163161 Excision repair cross-complementation group 3 2 127257290-127294176 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB037153, HPA046077 Approved Validated Nucleoplasm Liver cancer:1.62e-7 (unfavourable), Renal cancer:4.30e-6 (unfavourable) Expressed in all Expressed in all testis: 54.8 ERCC4 FANCQ, RAD1, XPF ENSG00000175595 Excision repair cross-complementation group 4 16 13920157-13952345 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB000156, HPA045828 Approved Supported Nucleoplasm
Nuclear bodies Expressed in all Mixed testis: 10.7 ERCC5 ERCM2, XPGC ENSG00000134899 Excision repair cross-complementation group 5 13 102844844-102876001 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA045845, HPA050374 Supported Approved Nucleoplasm Renal cancer:2.96e-6 (unfavourable), Urothelial cancer:6.82e-4 (favourable) Expressed in all Expressed in all spleen: 38.2 EXT1 LGCR, LGS, ttv ENSG00000182197 Exostosin glycosyltransferase 1 8 117794490-118111853 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA044394 Uncertain Lung cancer:1.20e-5 (unfavourable), Thyroid cancer:4.64e-4 (unfavourable), Cervical cancer:7.04e-4 (unfavourable) Expressed in all Expressed in all duodenum: 32.5 EXT2 SOTV ENSG00000151348 Exostosin glycosyltransferase 2 11 44095549-44245429 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA078409 Supported Golgi apparatus Renal cancer:5.36e-6 (unfavourable), Head and neck cancer:2.50e-4 (unfavourable) Expressed in all Expressed in all placenta: 89.9 FANCA FA-H, FAA, FACA, FAH, FANCH ENSG00000187741 Fanconi anemia, complementation group A 16 89737549-89816657 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA063236 Supported Nucleus Mixed Mixed testis: 19.5 FANCC FA3, FAC, FACC ENSG00000158169 Fanconi anemia, complementation group C 9 95099054-95317709 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB017793, HPA030771 Approved Supported Nucleoplasm Renal cancer:6.03e-6 (favourable) Expressed in all Mixed testis: 18.1 FANCD2 FA-D2, FACD, FAD, FANCD ENSG00000144554 Fanconi anemia, complementation group D2 3 10026414-10101930 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB016117, HPA063742 Approved Supported Nucleus
Nuclear bodies
Cytosol Ovarian cancer:5.00e-5 (unfavourable) Expressed in all Mixed testis: 21.7 FANCE FACE, FAE ENSG00000112039 Fanconi anemia, complementation group E 6 35452361-35467103 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB014893 Supported Supported Nucleoplasm Liver cancer:2.08e-9 (unfavourable), Endometrial cancer:6.25e-4 (unfavourable) Expressed in all Mixed skin: 16.2 FANCG FAG, XRCC9 ENSG00000221829 Fanconi anemia, complementation group G 9 35073835-35080016 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB008105, HPA045335 Approved Supported Nucleoli
Plasma membrane
Cytosol Renal cancer:2.38e-7 (unfavourable), Liver cancer:2.02e-4 (unfavourable) Expressed in all Mixed fallopian tube: 8.5 FH fumarase ENSG00000091483 Fumarate hydratase 1 241497603-241519761 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB017785, HPA025770, HPA025948, HPA027341 Supported Approved Validated Mitochondria Renal cancer:2.76e-7 (favourable) Expressed in all Expressed in all liver: 141.9 FLCN BHD, MGC17998, MGC23445 ENSG00000154803 Folliculin 17 17212212-17237188 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB015158, HPA028760 Supported Supported Plasma membrane
Cytosol Pancreatic cancer:4.49e-4 (favourable) Expressed in all Expressed in all endometrium: 30.7 GPC3 DGSX, OCI-5, SDYS, SGB, SGBS, SGBS1 ENSG00000147257 Glypican 3 X 133535745-133985895 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA006316 Approved Plasma membrane Stomach cancer:4.83e-4 (unfavourable) Expressed in all Tissue enriched 6 placenta: 838.1 lung: 130.8 HNF1A HCF-1A, HNF1, LFB1, MODY3, TCF1 ENSG00000135100 HNF1 homeobox A 12 120978543-121002512 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB010430, HPA035231 Supported Supported Nucleoplasm Mixed Tissue enhanced duodenum: 15.9;kidney: 10.1;small intestine: 16.0 liver: 5.8 HRAS HRAS1 ENSG00000174775 Harvey rat sarcoma viral oncogene homolog 11 532242-537287 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level CAB002015, HPA049830 Approved Liver cancer:2.32e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 25.0 KIT C-Kit, CD117, PBT, SCFR ENSG00000157404 V-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 4 54657918-54740715 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins Evidence at protein level CAB003288, HPA004471, CAB068253, CAB072867, HPA073252 Supported Supported Plasma membrane Renal cancer:5.63e-4 (favourable) Mixed Tissue enhanced breast: 133.8 thyroid gland: 78.4 MAX bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8 ENSG00000125952 MYC associated factor X 14 65006174-65102695 Cancer-related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000328, HPA003474 Supported Supported Nucleoplasm
Golgi apparatus
Vesicles Thyroid cancer:2.12e-4 (favourable), Renal cancer:5.57e-4 (unfavourable) Expressed in all Expressed in all spleen: 80.2 MEN1 ENSG00000133895 Multiple endocrine neoplasia I 11 64803510-64811294 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA030342 Uncertain Supported Nucleoplasm
Cytosol Stomach cancer:6.31e-5 (favourable), Liver cancer:1.08e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 22.2 MLH1 COCA2, FCC2, HNPCC, HNPCC2 ENSG00000076242 MutL homolog 1 3 36993332-37050918 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB013294, HPA052707, HPA060714, CAB070868 Supported Validated Nucleoplasm Liver cancer:8.24e-5 (unfavourable) Expressed in all Expressed in all testis: 59.7 MPL CD110, TPOR ENSG00000117400 MPL proto-oncogene, thrombopoietin receptor 1 43337807-43352772 Cancer-related genes, CD markers, Disease related genes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level HPA007619 Uncertain Plasma membrane Not detected Tissue enhanced testis: 1.8 ovary: 1.3 MSH2 COCA1, HNPCC, HNPCC1 ENSG00000095002 MutS homolog 2 2 47402969-47562311 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009572, CAB070867 Supported Approved Nucleoplasm
Vesicles Liver cancer:1.72e-9 (unfavourable), Endometrial cancer:4.44e-4 (unfavourable), Pancreatic cancer:4.63e-4 (unfavourable) Expressed in all Expressed in all testis: 32.6 MSH6 GTBP ENSG00000116062 MutS homolog 6 2 47695530-47810101 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009091, HPA028376, HPA028446 Supported Supported Nucleoplasm
Golgi apparatus
Vesicles Renal cancer:1.06e-7 (unfavourable), Endometrial cancer:1.34e-4 (unfavourable), Liver cancer:7.86e-4 (unfavourable) Expressed in all Expressed in all ovary: 74.4 MUTYH MYH ENSG00000132781 MutY DNA glycosylase 1 45329163-45340470 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA008732 Uncertain Supported Nucleus Liver cancer:4.76e-8 (unfavourable), Renal cancer:7.25e-5 (unfavourable) Expressed in all Mixed thyroid gland: 10.7 NBN AT-V1, AT-V2, ATV, NBS, NBS1 ENSG00000104320 Nibrin 8 89933336-90003228 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA001429, CAB003836 Supported Approved Nucleoplasm
Golgi apparatus Lung cancer:5.46e-5 (unfavourable), Pancreatic cancer:4.20e-4 (unfavourable) Expressed in all Expressed in all appendix: 38.1 NF1 ENSG00000196712 Neurofibromin 1 17 31094927-31382116 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins Evidence at protein level HPA045502 Uncertain Approved Mitochondria Expressed in all Expressed in all parathyroid gland: 31.9 NF2 merlin ENSG00000186575 Neurofibromin 2 (merlin) 22 29603556-29698598 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA003097, CAB005385 Supported Validated Nucleus
Plasma membrane
Cytosol Renal cancer:2.89e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 57.6 PALB2 FANCN, FLJ21816 ENSG00000083093 Partner and localizer of BRCA2 16 23603160-23641310 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB014895, HPA057000 Approved Supported Nucleoplasm Pancreatic cancer:2.35e-5 (unfavourable), Colorectal cancer:2.83e-5 (favourable) Expressed in all Mixed testis: 14.4 PDGFRA CD140a, GAS9, PDGFR2 ENSG00000134853 Platelet-derived growth factor receptor, alpha polypeptide 4 54229097-54298247 Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins Evidence at protein level HPA004947, CAB018143 Supported Supported Nucleus
Plasma membrane
Cell Junctions Renal cancer:9.79e-6 (unfavourable), Head and neck cancer:9.33e-4 (favourable) Expressed in all Expressed in all ovary: 222.0 PHOX2B NBPhox, Phox2b, PMX2B ENSG00000109132 Paired-like homeobox 2b 4 41744082-41748970 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA074325 Supported Nucleoplasm Not detected Tissue enriched 8 adrenal gland: 10.4 small intestine: 1.2 PMS1 MLH2, PMSL1 ENSG00000064933 PMS1 homolog 1, mismatch repair system component 2 189784085-189877629 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB010233, HPA031013 Approved Supported Nucleoplasm
Nuclear bodies Renal cancer:1.86e-6 (unfavourable), Liver cancer:2.38e-6 (unfavourable), Urothelial cancer:3.73e-4 (favourable) Expressed in all Expressed in all testis: 84.8 PMS2 HNPCC4, H_DJ0042M02.9, MLH4, PMSL2 ENSG00000122512 PMS1 homolog 2, mismatch repair system component 7 5973239-6009125 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB010235, HPA044400, HPA066490, HPA070310 Approved Validated Nucleoplasm
Cytosol Renal cancer:1.23e-5 (favourable) Expressed in all Mixed cerebral cortex: 20.0 POLE POLE1 ENSG00000177084 Polymerase (DNA directed), epsilon, catalytic subunit 12 132623753-132687365 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA058210, HPA067385 Validated Nucleus
Plasma membrane Renal cancer:3.19e-8 (unfavourable), Melanoma:1.44e-4 (unfavourable) Expressed in all Expressed in all testis: 22.0 PRF1 HPLH2, P1, PFP ENSG00000180644 Perforin 1 (pore forming protein) 10 70597348-70602775 Cancer-related genes, Disease related genes, Predicted secreted proteins Evidence at protein level CAB002436, HPA037940 Approved Approved Cytosol Renal cancer:1.08e-5 (unfavourable), Endometrial cancer:2.09e-4 (favourable), Head and neck cancer:3.54e-4 (favourable) Expressed in all Tissue enhanced spleen: 54.5 lymph node: 21.2 PRKAR1A CNC1, PRKAR1, TSE1 ENSG00000108946 Protein kinase, cAMP-dependent, regulatory, type I, alpha 17 68511780-68551319 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB019378, HPA049979 Approved Approved Cytosol Expressed in all Expressed in all parathyroid gland: 555.0 PTCH1 BCNS, NBCCS, PTCH ENSG00000185920 Patched 1 9 95442980-95517057 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB013717, HPA075072 Uncertain Approved Golgi apparatus Mixed Tissue enhanced cervix, uterine: 41.6 endometrium: 27.2 PTEN BZS, MHAM, MMAC1, PTEN1, TEP1 ENSG00000171862 Phosphatase and tensin homolog 10 87863113-87971930 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB004076, HPA031335 Uncertain Supported Nucleoplasm
Cytosol Renal cancer:7.35e-4 (unfavourable) Expressed in all Mixed testis: 59.0 RB1 OSRC, PPP1R130, RB ENSG00000139687 Retinoblastoma 1 13 48303751-48481986 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB000095, CAB016687, HPA050082 Supported Validated Nucleoplasm Ovarian cancer:6.92e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 36.0 RECQL4 RecQ4 ENSG00000160957 RecQ helicase-like 4 8 144511288-144517845 Cancer-related genes, Predicted intracellular proteins Evidence at protein level CAB017800, HPA025821 Supported Validated Nucleus Liver cancer:1.91e-4 (unfavourable) Expressed in all Mixed testis: 17.4 RET CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51 ENSG00000165731 Ret proto-oncogene 10 43077027-43130351 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB002581, HPA008356, HPA008495, CAB018342 Approved Supported Supported Vesicles
Plasma membrane
Cytosol Endometrial cancer:5.02e-4 (unfavourable) Tissue enhanced Tissue enriched 5 parathyroid gland: 146.8 adrenal gland: 29.2 SBDS CGI-97, FLJ10917, SDS, SWDS ENSG00000126524 Shwachman-Bodian-Diamond syndrome 7 66987677-66995601 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA028891 Approved Supported Nucleus
Cytosol Breast cancer:1.49e-4 (unfavourable), Head and neck cancer:3.65e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 238.7 SDHAF2 C11orf79, FLJ20487, PGL2, SDH5 ENSG00000167985 Succinate dehydrogenase complex assembly factor 2 11 61430042-61447529 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA039464, HPA039732 Supported Supported Nucleoli
Mitochondria
Cytosol Expressed in all Expressed in all fallopian tube: 35.7 SDHB SDH, SDH1 ENSG00000117118 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1 17018722-17054170 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA002868, CAB009822, CAB068233, CAB068234, CAB068235 Supported Supported Nucleoplasm
Plasma membrane
Mitochondria Renal cancer:2.93e-7 (favourable) Expressed in all Expressed in all kidney: 213.3 SDHD PGL, PGL1 ENSG00000204370 Succinate dehydrogenase complex, subunit D, integral membrane protein 11 112086773-112120013 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, FDA approved drug targets, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA045727 Approved Renal cancer:1.99e-10 (favourable) Expressed in all Expressed in all kidney: 303.5 SETBP1 KIAA0437, SEB ENSG00000152217 SET binding protein 1 18 44680173-45068510 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA049022, HPA057259 Uncertain Supported Nucleus
Nuclear bodies
Cytosol Renal cancer:6.34e-8 (favourable) Mixed Expressed in all seminal vesicle: 13.8 SMAD4 DPC4, MADH4 ENSG00000141646 SMAD family member 4 18 51028394-51085045 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA019154 Approved Supported Nucleoplasm
Centrosome
Cytosol Renal cancer:1.92e-5 (favourable) Expressed in all Expressed in all parathyroid gland: 38.7 SMARCB1 BAF47, hSNFS, Ini1, PPP1R144, RDT, Sfh1p, SNF5, SNF5L1, Snr1 ENSG00000099956 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 22 23786963-23834516 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009196, HPA018248, HPA019127 Supported Supported Nucleoplasm
Nucleoli fibrillar center Renal cancer:1.14e-6 (favourable), Liver cancer:6.52e-4 (unfavourable) Expressed in all Expressed in all testis: 51.2 SMARCE1 BAF57 ENSG00000073584 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 17 40624962-40648508 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA003916, CAB037318 Supported Supported Nucleoplasm Expressed in all Expressed in all endometrium: 72.9 STAT3 APRF ENSG00000168610 Signal transducer and activator of transcription 3 (acute-phase response factor) 17 42313324-42388568 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Transcription factors Evidence at protein level HPA001671, CAB003859, HPA058603, CAB068241, CAB068242 Supported Supported Nucleoplasm
Cytosol Expressed in all Expressed in all gallbladder: 127.9 STK11 LKB1, PJS ENSG00000118046 Serine/threonine kinase 11 19 1177558-1228435 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB016231, HPA017254, CAB022105, HPA067481 Approved Supported Nucleoplasm
Cytosol Endometrial cancer:3.69e-5 (favourable), Head and neck cancer:1.96e-4 (favourable) Expressed in all Expressed in all testis: 70.3 SUFU PRO1280, SUFUH, SUFUXL ENSG00000107882 Suppressor of fused homolog (Drosophila) 10 102503987-102633535 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA008700 Supported Supported Nucleus Expressed in all Mixed parathyroid gland: 15.8 TERT EST2, hEST2, TCS1, TP2, TRT ENSG00000164362 Telomerase reverse transcriptase 5 1253147-1295069 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA054641, HPA065897 Validated Nucleoplasm Mixed Not detected lymph node,testis: 0.5 TP53 LFS1, p53 ENSG00000141510 Tumor protein p53 17 7661779-7687550 Cancer-related genes, Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors, Transporters Evidence at protein level CAB002973, CAB039238, CAB039239, HPA051244, CAB072876 Supported Validated Nucleoplasm Endometrial cancer:1.35e-4 (favourable), Prostate cancer:5.01e-4 (unfavourable) Expressed in all Expressed in all fallopian tube: 50.3 TSC1 hamartin, KIAA0243, LAM, TSC ENSG00000165699 Tuberous sclerosis 1 9 132891348-132944633 Cancer-related genes, Disease related genes, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB011568, CAB012481, HPA074132 Supported Validated Cytosol Liver cancer:6.03e-6 (unfavourable), Renal cancer:7.91e-4 (favourable), Pancreatic cancer:8.01e-4 (favourable) Expressed in all Expressed in all testis: 34.3 TSC2 LAM, PPP1R160, TSC4, tuberin ENSG00000103197 Tuberous sclerosis 2 16 2047465-2088720 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB002225, HPA030409, HPA049679 Approved Validated Cytosol Pancreatic cancer:5.06e-4 (favourable) Expressed in all Expressed in all seminal vesicle: 35.7 TSHR LGR3 ENSG00000165409 Thyroid stimulating hormone receptor 14 80954989-81146302 Cancer-related genes, Disease related genes, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB000473 Approved Tissue enriched Tissue enriched 277 thyroid gland: 443.8 lymph node: 1.6 VHL VHL1 ENSG00000134086 Von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 3 10141008-10152220 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB005430, HPA031631, HPA031632 Uncertain Validated Nucleoplasm
Cytosol Liver cancer:1.32e-5 (unfavourable), Breast cancer:9.02e-5 (unfavourable), Stomach cancer:7.84e-4 (favourable) Expressed in all Expressed in all lymph node: 35.2 WAS IMD2, THC, WASP, WASPA ENSG00000015285 Wiskott-Aldrich syndrome X 48676596-48691427 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level HPA002022, CAB004290 Supported Renal cancer:5.58e-6 (unfavourable), Head and neck cancer:3.78e-4 (favourable), Endometrial cancer:4.95e-4 (favourable) Expressed in all Tissue enhanced appendix: 71.0;lymph node: 61.6;spleen: 70.8 bone marrow: 37.6 WRN RECQ3, RECQL2 ENSG00000165392 Werner syndrome, RecQ helicase-like 8 31033801-31173769 Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA028661 Approved Supported Nuclear speckles Expressed in all Mixed endometrium: 14.7 WT1 AWT1, GUD, WAGR, WIT-2 ENSG00000184937 Wilms tumor 1 11 32387775-32435630 Cancer-related genes, Disease related genes, Predicted intracellular proteins, Transcription factors Evidence at protein level CAB000327, HPA035717, HPA053848 Supported Supported Nucleoplasm Tissue enriched Tissue enhanced endometrium: 112.0;fallopian tube: 123.1;smooth muscle: 78.9 testis: 53.8 XPA XP1, XPAC ENSG00000136936 Xeroderma pigmentosum, complementation group A 9 97674909-97697357 Cancer-related genes, Disease related genes, Predicted intracellular proteins Evidence at protein level CAB000155, HPA056856 Supported Approved Nucleus
Cytokinetic bridge Renal cancer:4.28e-5 (favourable) Expressed in all Expressed in all thyroid gland: 38.9 XPC RAD4, XPCC ENSG00000154767 Xeroderma pigmentosum, complementation group C 3 14145147-14178783 Cancer-related genes, Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB009932, HPA035707, HPA069673 Supported Validated Nucleus
Plasma membrane Renal cancer:4.14e-7 (favourable), Urothelial cancer:2.46e-4 (favourable) Expressed in all Expressed in all parathyroid gland: 51.3