Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific ACOT13 HT012, THEM2 ENSG00000112304 Acyl-CoA thioesterase 13 6 24667035-24705065 Predicted intracellular proteins Evidence at protein level HPA019881 Approved Approved Cell Junctions Ovarian cancer:2.53e-6 (favourable) Expressed in all Expressed in all kidney: 20.9 ADAM22 MDC2 ENSG00000008277 ADAM metallopeptidase domain 22 7 87934143-88202889 Enzymes, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA050325 Approved Cell Junctions Mixed Tissue enhanced cerebral cortex: 47.7 prostate: 17.5 ARHGAP28 FLJ10312, KIAA1314 ENSG00000088756 Rho GTPase activating protein 28 18 6729718-6915716 Predicted intracellular proteins Evidence at protein level HPA030413, HPA030414, HPA030415 Supported Supported Cell Junctions Mixed Tissue enhanced testis: 132.2 placenta: 40.5 BVES HBVES, POP1, POPDC1 ENSG00000112276 Blood vessel epicardial substance 6 105096822-105137174 Predicted membrane proteins Evidence at protein level HPA014788, HPA018176 Supported Supported Cell Junctions Mixed Tissue enhanced smooth muscle: 24.7 testis: 20.7 C11orf52 FLJ25219, MGC14839 ENSG00000149300 Chromosome 11 open reading frame 52 11 111918032-111926872 Predicted intracellular proteins Evidence at protein level HPA038387, HPA038388 Uncertain Validated Cell Junctions Not detected Mixed kidney: 44.8 C17orf104 FLJ35848 ENSG00000180336 Chromosome 17 open reading frame 104 17 44656404-44690308 Predicted intracellular proteins Evidence at protein level HPA027266 Uncertain Uncertain Cell Junctions Not detected Tissue enriched 51 testis: 85.8 cerebral cortex: 1.6 C4orf19 FLJ11017 ENSG00000154274 Chromosome 4 open reading frame 19 4 37453941-37623495 Predicted intracellular proteins Evidence at protein level HPA043458, HPA052894 Approved Supported Cell Junctions Renal cancer:1.49e-11 (favourable) Mixed Mixed rectum: 27.4 C9orf3 AOPEP, AP-O, APO, C90RF3, FLJ14675 ENSG00000148120 Chromosome 9 open reading frame 3 9 94726701-95087218 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA004633, HPA072729 Approved Approved Cell Junctions Renal cancer:6.33e-5 (favourable) Expressed in all Expressed in all skin: 50.1 CADM1 BL2, IGSF4, IGSF4A, Necl-2, NECL2, RA175, ST17, SYNCAM, SYNCAM1, TSLC1 ENSG00000182985 Cell adhesion molecule 1 11 115169218-115504957 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB037266 Supported Supported Cell Junctions Endometrial cancer:1.32e-4 (favourable) Expressed in all Mixed parathyroid gland: 119.5 CDH17 cadherin, HPT-1 ENSG00000079112 Cadherin 17, LI cadherin (liver-intestine) 8 94127171-94217303 Cancer-related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA023614, HPA023616, CAB025143, HPA026556 Supported Supported Cell Junctions Group enriched Group enriched 7 colon: 261.7;duodenum: 323.0;rectum: 272.5;small intestine: 300.5 appendix: 39.2 CDRT15 ENSG00000223510 CMT1A duplicated region transcript 15 17 14235673-14236862 Predicted intracellular proteins Evidence at protein level HPA055952 Uncertain Approved Cell Junctions Not detected Tissue enhanced testis: 11.6 skin: 4.0 CGNL1 FLJ14957, JACOP, KIAA1749, paracingulin ENSG00000128849 Cingulin-like 1 15 57375967-57550727 Disease related genes, Predicted intracellular proteins Evidence at protein level CAB013500, HPA056911, HPA069214 Supported Approved Cell Junctions Renal cancer:1.37e-6 (favourable), Endometrial cancer:3.55e-4 (favourable), Liver cancer:5.58e-4 (favourable) Expressed in all Mixed kidney: 72.7 CLDN3 C7orf1, CPE-R2, CPETR2, HRVP1, RVP1 ENSG00000165215 Claudin 3 7 73768997-73770270 Cancer-related genes, Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB002702, HPA014361 Supported Supported Cell Junctions Renal cancer:3.39e-5 (favourable) Mixed Tissue enhanced colon: 89.6;small intestine: 121.9 duodenum: 56.5 CRB3 MGC17303 ENSG00000130545 Crumbs family member 3 19 6463777-6467221 Predicted membrane proteins Evidence at protein level HPA013835 Approved Supported Cell Junctions Renal cancer:0.00e+0 (favourable), Urothelial cancer:8.06e-5 (favourable), Endometrial cancer:4.54e-4 (favourable) Mixed Mixed duodenum: 38.4 DLG5 KIAA0583, P-dlg ENSG00000151208 Discs, large homolog 5 (Drosophila) 10 77790791-77926526 Predicted intracellular proteins Evidence at protein level HPA001746 Supported Cell Junctions Liver cancer:5.38e-4 (unfavourable) Expressed in all Mixed parathyroid gland: 33.2 DNAJC18 MGC29463 ENSG00000170464 DnaJ (Hsp40) homolog, subfamily C, member 18 5 139408588-139444491 Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA036538, HPA060154 Approved Supported Cell Junctions Pancreatic cancer:5.89e-4 (favourable) Mixed Group enriched 5 cerebral cortex: 30.2;testis: 115.2 ovary: 13.8 DSG2 CDHF5 ENSG00000046604 Desmoglein 2 18 31498043-31549008 Disease related genes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA004896, CAB025122 Supported Supported Cell Junctions Renal cancer:3.14e-10 (favourable), Pancreatic cancer:4.94e-5 (unfavourable), Lung cancer:2.43e-4 (unfavourable), Head and neck cancer:5.63e-4 (unfavourable), Colorectal cancer:7.81e-4 (favourable), Cervical cancer:8.22e-4 (unfavourable) Expressed in all Tissue enhanced parathyroid gland: 246.8 rectum: 108.5 DSP DPI, DPII, KPPS2, PPKS2 ENSG00000096696 Desmoplakin 6 7541575-7586717 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB037324, HPA045840, HPA054950 Supported Validated Cell Junctions Renal cancer:1.53e-9 (favourable), Urothelial cancer:1.82e-4 (unfavourable) Tissue enhanced Group enriched 8 esophagus: 346.9;skin: 1019.0 placenta: 88.5 EDA2R EDA-A2R, EDAA2R, TNFRSF27, XEDAR ENSG00000131080 Ectodysplasin A2 receptor X 66595637-66639298 Predicted membrane proteins Evidence at protein level HPA054522 Approved Cell Junctions Mixed Mixed thyroid gland: 9.5 FIBCD1 FLJ14810 ENSG00000130720 Fibrinogen C domain containing 1 9 130902438-130939286 Predicted intracellular proteins Evidence at protein level HPA053898, HPA055353 Uncertain Supported Cell Junctions Mixed Tissue enhanced adrenal gland: 4.7;parathyroid gland: 8.5;testis: 5.3 cerebral cortex: 2.5 FLVCR1 AXPC1, FLVCR, MFSD7B, PCA ENSG00000162769 Feline leukemia virus subgroup C cellular receptor 1 1 212858255-212899363 Disease related genes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level HPA046646 Approved Approved Cell Junctions Renal cancer:1.06e-5 (unfavourable), Liver cancer:2.52e-5 (unfavourable), Pancreatic cancer:3.50e-4 (favourable) Expressed in all Tissue enhanced small intestine: 21.9 duodenum: 10.0 FRS2 FRS2A, FRS2alpha, SNT-1, SNT1 ENSG00000166225 Fibroblast growth factor receptor substrate 2 12 69470349-69579789 Predicted intracellular proteins Evidence at protein level HPA038323 Approved Cell Junctions Expressed in all Expressed in all parathyroid gland: 27.0 GABRA5 ENSG00000186297 Gamma-aminobutyric acid (GABA) A receptor, alpha 5 15 26866363-26949207 FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA077031 Supported Cell Junctions Mixed Tissue enriched 43 cerebral cortex: 82.0 esophagus: 1.8 GJB4 CX30.3 ENSG00000189433 Gap junction protein, beta 4, 30.3kDa 1 34759741-34763724 Disease related genes, Predicted membrane proteins Evidence at protein level HPA055112 Supported Cell Junctions Pancreatic cancer:3.24e-5 (unfavourable), Cervical cancer:5.48e-4 (favourable) Group enriched Tissue enriched 5 skin: 27.8 epididymis: 5.0 GJB6 CX30, DFNA3, ED2, EDH, HED ENSG00000121742 Gap junction protein, beta 6, 30kDa 13 20221971-20232395 Disease related genes, Predicted membrane proteins Evidence at protein level HPA014846 Supported Cell Junctions Tissue enhanced Group enriched 5 bone marrow: 47.6;cerebral cortex: 39.6;esophagus: 150.3;skin: 32.0 tonsil: 12.7 HCAR2 GPR109A, HCA2, HM74A, NIACR1, Puma-g, PUMAG ENSG00000182782 Hydroxycarboxylic acid receptor 2 12 122701293-122703343 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028660 Approved Approved Cell Junctions Group enriched Tissue enhanced spleen: 36.5 esophagus: 25.6 HCAR3 GPR109B, HCA3, HM74 ENSG00000255398 Hydroxycarboxylic acid receptor 3 12 122714756-122716892 FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins Evidence at protein level HPA028660 Approved Approved Cell Junctions Mixed Tissue enhanced bone marrow: 16.7;spleen: 22.1 appendix: 12.6 LDLRAD3 LRAD3 ENSG00000179241 Low density lipoprotein receptor class A domain containing 3 11 35943981-36232136 Predicted membrane proteins Evidence at protein level HPA038251 Approved Supported Cell Junctions Renal cancer:5.05e-8 (unfavourable), Lung cancer:9.34e-6 (unfavourable), Urothelial cancer:2.14e-5 (unfavourable), Cervical cancer:2.24e-4 (unfavourable) Expressed in all Mixed breast: 22.9 MAGI3 MAGI-3 ENSG00000081026 Membrane associated guanylate kinase, WW and PDZ domain containing 3 1 113390749-113685923 Predicted intracellular proteins Evidence at protein level HPA007923, HPA008444 Approved Supported Cell Junctions Renal cancer:2.60e-8 (favourable), Ovarian cancer:4.29e-4 (favourable) Expressed in all Mixed lung: 20.9 MARVELD2 DFNB49, FLJ30532, MRVLDC2, TRIC ENSG00000152939 MARVEL domain containing 2 5 69415112-69444330 Disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA018119, HPA061726 Uncertain Supported Cell Junctions Renal cancer:2.84e-13 (favourable) Mixed Tissue enhanced thyroid gland: 19.7 small intestine: 8.9 MPP7 FLJ32798 ENSG00000150054 Membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 10 28050993-28334486 Predicted intracellular proteins Evidence at protein level HPA037597, HPA037598 Supported Supported Cell Junctions Renal cancer:2.79e-14 (favourable), Lung cancer:5.88e-4 (favourable) Mixed Mixed esophagus: 41.3 MPZL2 EVA, EVA1 ENSG00000149573 Myelin protein zero-like 2 11 118253403-118264536 Predicted membrane proteins Evidence at protein level HPA051395, HPA060740 Approved Approved Cell Junctions Pancreatic cancer:1.14e-4 (unfavourable), Thyroid cancer:1.62e-4 (favourable) Expressed in all Tissue enhanced esophagus: 210.0 urinary bladder: 122.3 MTHFR ENSG00000177000 Methylenetetrahydrofolate reductase (NAD(P)H) 1 11785723-11806920 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA063389 Approved Cell Junctions Head and neck cancer:3.97e-5 (favourable), Pancreatic cancer:4.81e-5 (favourable), Liver cancer:1.19e-4 (unfavourable), Renal cancer:2.12e-4 (favourable) Expressed in all Expressed in all epididymis: 65.3 NHS ENSG00000188158 Nance-Horan syndrome (congenital cataracts and dental anomalies) X 17375420-17735994 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA031497, HPA076257 Uncertain Supported Cell Junctions Endometrial cancer:1.68e-4 (favourable) Mixed Mixed endometrium: 7.8 PARD3 ASIP, Baz, Bazooka, PAR3, PARD3A, PPP1R118 ENSG00000148498 Par-3 family cell polarity regulator 10 34109560-34815325 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA030443 Approved Validated Cell Junctions Liver cancer:1.73e-5 (unfavourable), Urothelial cancer:4.41e-4 (unfavourable) Expressed in all Mixed skin: 68.8 PARD3B ALS2CR19, PAR3beta, Par3L ENSG00000116117 Par-3 family cell polarity regulator beta 2 204545793-205620162 Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA035283 Approved Supported Cell Junctions Renal cancer:2.67e-10 (favourable) Expressed in all Mixed parathyroid gland: 13.1 PGLYRP2 PGLYRPL, PGRP-L, PGRPL, tagL, tagL-alpha, tagl-beta, TAGL-like ENSG00000161031 Peptidoglycan recognition protein 2 19 15468645-15498956 Enzymes, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins Evidence at protein level CAB033468, HPA043568, HPA046311, HPA075237 Approved Approved Cell Junctions Tissue enriched Tissue enriched 17 liver: 132.5 testis: 7.8 PLEKHG4 ARHGEF44, DKFZP434I216, SCA4 ENSG00000196155 Pleckstrin homology domain containing, family G (with RhoGef domain) member 4 16 67277510-67289499 Predicted intracellular proteins Evidence at protein level HPA055696 Approved Cell Junctions Renal cancer:6.72e-9 (unfavourable) Expressed in all Tissue enhanced testis: 41.3 ovary: 18.7 SHKBP1 PP203, Sb1 ENSG00000160410 SH3KBP1 binding protein 1 19 40576851-40591399 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA041887 Uncertain Approved Cell Junctions Expressed in all Expressed in all spleen: 54.3 SLC5A6 SMVT ENSG00000138074 Solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2 27199587-27212958 Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, Transporters Evidence at protein level HPA036958 Approved Approved Cell Junctions Renal cancer:3.60e-7 (unfavourable) Expressed in all Expressed in all epididymis: 82.1 SLC9A2 NHE2 ENSG00000115616 Solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 2 102619707-102711318 Plasma proteins, Predicted membrane proteins, Transporters Evidence at protein level HPA035121, HPA035122 Approved Approved Cell Junctions Mixed Tissue enhanced colon: 20.9;rectum: 23.7;stomach: 25.8 testis: 10.6 SLCO4A1 OATP-E, OATP4A1, SLC21A12 ENSG00000101187 Solute carrier organic anion transporter family, member 4A1 20 62642445-62685785 Predicted membrane proteins, Transporters Evidence at protein level HPA030669, HPA030670 Uncertain Approved Cell Junctions Lung cancer:4.74e-4 (unfavourable) Expressed in all Mixed esophagus: 10.6 SLIT3 MEGF5, SLIL2, Slit-3, SLIT1, slit2 ENSG00000184347 Slit guidance ligand 3 5 168661733-169301129 Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA051630 Approved Approved Cell Junctions Renal cancer:2.45e-5 (unfavourable) Mixed Mixed parathyroid gland: 98.0 SRCIN1 KIAA1684, p140Cap, SNIP ENSG00000277363 SRC kinase signaling inhibitor 1 17 38530016-38605930 Predicted intracellular proteins Evidence at protein level HPA009701, HPA063795 Approved Approved Cell Junctions Urothelial cancer:1.76e-4 (favourable) Mixed Tissue enhanced cerebral cortex: 22.2 skin: 4.7 SSX2IP ENSG00000117155 Synovial sarcoma, X breakpoint 2 interacting protein 1 84643707-84690803 Predicted intracellular proteins Evidence at protein level HPA027306, HPA075946 Approved Approved Cell Junctions Colorectal cancer:1.45e-4 (favourable) Expressed in all Tissue enhanced testis: 191.0 cerebral cortex: 45.9 TCEB1 SIII ENSG00000154582 Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) 8 73939169-73972287 Cancer-related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA078113 Approved Cell Junctions Breast cancer:6.48e-4 (unfavourable) Expressed in all Expressed in all testis: 162.2 TJP1 DKFZp686M05161, MGC133289, ZO-1 ENSG00000104067 Tight junction protein 1 15 29699367-29968865 Predicted intracellular proteins Evidence at protein level HPA001636, HPA001637, CAB010822 Supported Validated Cell Junctions Renal cancer:1.72e-4 (favourable) Expressed in all Mixed cerebral cortex: 49.8 TMEM186 C16orf51, DKFZP564K2062 ENSG00000184857 Transmembrane protein 186 16 8780384-8797648 Predicted membrane proteins Evidence at protein level HPA018226, HPA063559 Uncertain Approved Cell Junctions Renal cancer:1.93e-8 (favourable) Expressed in all Expressed in all parathyroid gland: 22.5 TNFRSF25 APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR ENSG00000215788 Tumor necrosis factor receptor superfamily, member 25 1 6461151-6466195 Predicted membrane proteins, Predicted secreted proteins Evidence at protein level HPA077620 Approved Cell Junctions Renal cancer:1.65e-7 (unfavourable), Head and neck cancer:3.09e-4 (favourable), Colorectal cancer:4.46e-4 (unfavourable) Expressed in all Tissue enhanced skin: 29.7 spleen: 12.3 TNK1 ENSG00000174292 Tyrosine kinase, non-receptor, 1 17 7380534-7389774 Enzymes, Predicted intracellular proteins Evidence at protein level HPA012065, HPA056452 Uncertain Approved Cell Junctions Urothelial cancer:1.52e-4 (favourable), Endometrial cancer:4.28e-4 (favourable), Renal cancer:6.40e-4 (favourable) Mixed Mixed skin: 10.3 TSSK4 C14orf20, STK22E ENSG00000139908 Testis-specific serine kinase 4 14 24205697-24208362 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA060660 Approved Cell Junctions Mixed Tissue enhanced testis: 42.8 parathyroid gland: 10.8 VCAM1 CD106 ENSG00000162692 Vascular cell adhesion molecule 1 1 100719742-100739045 Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins Evidence at protein level CAB000154, HPA034796, HPA069867 Supported Approved Cell Junctions Head and neck cancer:7.19e-5 (favourable), Cervical cancer:3.82e-4 (favourable) Tissue enriched Tissue enriched 5 spleen: 557.0 lymph node: 111.2 VPS13B CHS1, COH1 ENSG00000132549 Vacuolar protein sorting 13 homolog B (yeast) 8 99013266-99877580 Disease related genes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA043865 Approved Cell Junctions Expressed in all Mixed parathyroid gland: 14.4 WDPCP BBS15, C2orf86, fritz, hFrtz ENSG00000143951 WD repeat containing planar cell polarity effector 2 63121383-63827843 Disease related genes, Predicted intracellular proteins Evidence at protein level HPA044144 Uncertain Approved Cell Junctions Mixed Mixed testis: 11.9