Gene Gene synonym Ensembl Gene description Chromosome Position Protein class Evidence Antibody Reliability (IH) Reliability (Mouse Brain) Reliability (IF) Subcellular location Prognostic p-value RNA cancer category RNA tissue category RNA TS RNA TS TPM TPM max in non-specific AASS LKRSDH, LORSDH ENSG00000008311 Aminoadipate-semialdehyde synthase 7 122075647-122144280 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA020637, HPA020728, HPA020734 Supported Validated Vesicles
Mitochondria Liver cancer:9.81e-4 (favourable) Expressed in all Mixed ovary: 30.6 ACADM ACAD1, MCAD, MCADH ENSG00000117054 Acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1 75724347-75787575 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA006198, HPA026542 Supported Validated Mitochondria Renal cancer:3.83e-8 (favourable), Colorectal cancer:7.30e-4 (favourable) Expressed in all Expressed in all kidney: 325.2 ACADS ACAD3, SCAD ENSG00000122971 Acyl-CoA dehydrogenase, C-2 to C-3 short chain 12 120725735-120740008 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA004799, CAB019284, HPA022271 Supported Supported Nucleoplasm
Mitochondria Renal cancer:3.33e-6 (favourable), Urothelial cancer:6.34e-5 (favourable), Liver cancer:2.43e-4 (favourable), Endometrial cancer:5.05e-4 (favourable), Glioma:9.94e-4 (unfavourable) Expressed in all Expressed in all duodenum: 83.5 ACADSB ACAD7, SBCAD ENSG00000196177 Acyl-CoA dehydrogenase, short/branched chain 10 123008979-123058311 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA041458 Supported Supported Mitochondria Renal cancer:6.37e-12 (favourable), Pancreatic cancer:3.40e-4 (favourable) Expressed in all Expressed in all liver: 186.7 ACADVL ACAD6, LCACD, VLCAD ENSG00000072778 Acyl-CoA dehydrogenase, very long chain 17 7217125-7225273 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA019006, HPA020595 Supported Supported Nucleus
Nucleoli
Mitochondria Pancreatic cancer:6.87e-4 (favourable) Expressed in all Expressed in all adrenal gland: 455.8 ACOX2 BRCACOX, BRCOX, THCCox ENSG00000168306 Acyl-CoA oxidase 2, branched chain 3 58505136-58537319 Enzymes, Predicted intracellular proteins Evidence at protein level HPA038280, HPA064845 Approved Supported Vesicles
Mitochondria Tissue enhanced Tissue enhanced liver: 87.8 kidney: 42.3 ALDH18A1 GSAS, P5CS, PYCS ENSG00000059573 Aldehyde dehydrogenase 18 family, member A1 10 95605929-95656706 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA008333, HPA012604 Approved Validated Mitochondria Renal cancer:3.60e-9 (unfavourable), Endometrial cancer:4.20e-4 (favourable) Expressed in all Expressed in all duodenum: 92.0 ALDH1B1 ALDH5, ALDHX ENSG00000137124 Aldehyde dehydrogenase 1 family, member B1 9 38392664-38398661 Enzymes, Predicted intracellular proteins Evidence at protein level HPA021037 Approved Supported Nucleoplasm
Vesicles
Mitochondria Thyroid cancer:1.17e-5 (unfavourable), Renal cancer:2.05e-4 (favourable) Expressed in all Expressed in all smooth muscle: 176.4 ALDH1L2 FLJ38508, mtFDH ENSG00000136010 Aldehyde dehydrogenase 1 family, member L2 12 105019784-105084577 Enzymes, Predicted intracellular proteins Evidence at protein level HPA039481 Uncertain Supported Mitochondria Mixed Mixed cervix, uterine: 8.3 ALDH5A1 SSADH, SSDH ENSG00000112294 Aldehyde dehydrogenase 5 family, member A1 6 24494852-24537207 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA029715, HPA029716 Supported Validated Mitochondria Liver cancer:7.61e-6 (favourable), Renal cancer:3.68e-4 (favourable), Ovarian cancer:6.20e-4 (favourable) Expressed in all Expressed in all liver: 46.8 ALDH6A1 MMSDH ENSG00000119711 Aldehyde dehydrogenase 6 family, member A1 14 74056850-74084493 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA029072, HPA029073, HPA029074, HPA029075 Supported Validated Mitochondria Renal cancer:2.00e-15 (favourable), Lung cancer:4.22e-4 (favourable) Expressed in all Expressed in all kidney: 386.6 ALDH7A1 ATQ1, EPD, PDE ENSG00000164904 Aldehyde dehydrogenase 7 family, member A1 5 126541841-126595418 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA023296 Supported Supported Mitochondria
Cytosol Renal cancer:3.08e-4 (favourable) Expressed in all Expressed in all kidney: 162.4 BDH1 BDH, SDR9C1 ENSG00000161267 3-hydroxybutyrate dehydrogenase, type 1 3 197509783-197573323 Candidate cardiovascular disease genes, Enzymes, Predicted intracellular proteins Evidence at protein level HPA030947, HPA058709 Approved Validated Mitochondria Renal cancer:7.12e-8 (favourable), Liver cancer:9.86e-7 (favourable), Cervical cancer:1.09e-4 (favourable) Expressed in all Tissue enriched 6 liver: 168.8 colon: 27.4 CPOX CPO, CPX, HCP ENSG00000080819 Coproporphyrinogen oxidase 3 98521132-98593723 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA015736, HPA054448 Validated Mitochondria Renal cancer:1.04e-5 (unfavourable) Expressed in all Expressed in all bone marrow: 25.5 CYB5R1 humb5R2, NQO3A2 ENSG00000159348 Cytochrome b5 reductase 1 1 202961869-202967280 Enzymes, Predicted intracellular proteins Evidence at protein level HPA010641, HPA014147 Supported Uncertain Nucleoli
Mitochondria
Cytosol Endometrial cancer:1.14e-4 (favourable) Expressed in all Expressed in all skeletal muscle: 183.8 CYP1B1 CP1B, GLC3A ENSG00000138061 Cytochrome P450, family 1, subfamily B, polypeptide 1 2 38066973-38109902 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level CAB011705, HPA026863 Approved Uncertain Mitochondria Renal cancer:4.39e-6 (unfavourable), Urothelial cancer:2.76e-4 (unfavourable) Expressed in all Mixed fallopian tube: 75.4 CYP24A1 CP24, CYP24, P450-CC24 ENSG00000019186 Cytochrome P450, family 24, subfamily A, polypeptide 1 20 54153449-54173973 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA022261, HPA063771 Supported Supported Nucleoplasm
Plasma membrane
Mitochondria Mixed Tissue enhanced endometrium: 24.8;urinary bladder: 52.7 placenta: 13.9 CYP27A1 CP27, CTX, CYP27 ENSG00000135929 Cytochrome P450, family 27, subfamily A, polypeptide 1 2 218781749-218815293 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA059155 Approved Validated Mitochondria Liver cancer:8.62e-6 (favourable), Breast cancer:1.05e-4 (favourable) Expressed in all Tissue enhanced liver: 278.5 lung: 98.4 DECR1 DECR, SDR18C1 ENSG00000104325 2,4-dienoyl CoA reductase 1, mitochondrial 8 90001405-90052092 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA023160, HPA023162, HPA023238 Supported Supported Mitochondria
Cytosol Renal cancer:1.79e-7 (favourable), Breast cancer:1.49e-4 (unfavourable), Urothelial cancer:6.06e-4 (favourable) Expressed in all Expressed in all liver: 262.7 DEGS1 DEGS-1, Des-1, DES1, FADS7, MLD ENSG00000143753 Delta(4)-desaturase, sphingolipid 1 1 224175756-224193441 Enzymes, Predicted membrane proteins Evidence at protein level HPA076422 Supported Mitochondria Renal cancer:6.83e-7 (unfavourable), Liver cancer:4.29e-5 (unfavourable), Endometrial cancer:7.74e-5 (unfavourable), Urothelial cancer:2.53e-4 (unfavourable) Expressed in all Expressed in all skin: 617.7 DHFR ENSG00000228716 Dihydrofolate reductase 5 80626228-80654983 Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins Evidence at protein level CAB037129, HPA051465 Uncertain Supported Mitochondria Expressed in all Mixed lymph node: 50.1 DHFRL1 DHFRP4, FLJ16119 ENSG00000178700 Dihydrofolate reductase-like 1 3 94047836-94063389 Enzymes, Predicted intracellular proteins Evidence at protein level HPA051465 Uncertain Supported Mitochondria Renal cancer:2.30e-6 (favourable) Expressed in all Mixed parathyroid gland: 15.9 DHODH ENSG00000102967 Dihydroorotate dehydrogenase (quinone) 16 72008588-72027664 Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010123, HPA011942 Approved Supported Nucleoplasm
Mitochondria Expressed in all Mixed liver: 23.7 DHRS3 RDH17, retSDR1, Rsdr1, SDR1, SDR16C1 ENSG00000162496 Dehydrogenase/reductase (SDR family) member 3 1 12567910-12617731 Enzymes, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA010844 Supported Approved Nucleoli
Mitochondria Thyroid cancer:2.65e-4 (favourable) Expressed in all Expressed in all adipose tissue: 99.6 DHTKD1 CMT2Q, DKFZP762M115, KIAA1630, MGC3090 ENSG00000181192 Dehydrogenase E1 and transketolase domain containing 1 10 12068972-12123225 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA037949, HPA037950, HPA066098 Approved Supported Mitochondria Renal cancer:3.43e-4 (favourable) Expressed in all Expressed in all liver: 66.5 DLD DLDH, GCSL, LAD ENSG00000091140 Dihydrolipoamide dehydrogenase 7 107890970-107931730 Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA044849 Supported Supported Mitochondria Renal cancer:7.58e-9 (favourable) Expressed in all Expressed in all kidney: 119.6 DMGDH ENSG00000132837 Dimethylglycine dehydrogenase 5 78997606-79236038 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA036441, HPA036442, HPA077849 Supported Uncertain Mitochondria Renal cancer:1.17e-5 (favourable), Liver cancer:5.32e-5 (favourable) Group enriched Group enriched 11 kidney: 177.8;liver: 146.1 epididymis: 14.7 ETHE1 HSCO, YF13H12 ENSG00000105755 Ethylmalonic encephalopathy 1 19 43506719-43527244 Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA028360, HPA029028, HPA029029 Supported Validated Mitochondria Lung cancer:9.58e-4 (unfavourable) Expressed in all Expressed in all colon: 244.2 FDXR ADXR ENSG00000161513 Ferredoxin reductase 17 74862497-74873031 Enzymes, Predicted intracellular proteins Evidence at protein level CAB009818, HPA044393, HPA053673 Supported Validated Mitochondria Endometrial cancer:2.38e-4 (favourable) Expressed in all Tissue enriched 6 adrenal gland: 233.0 testis: 39.2 FXN CyaY, FA, FARR, FRDA, X25 ENSG00000165060 Frataxin 9 69035259-69100178 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins, Transporters Evidence at protein level CAB022164, HPA068304 Supported Supported Mitochondria
Cytosol Expressed in all Expressed in all parathyroid gland: 33.5 GCDH ACAD5 ENSG00000105607 Glutaryl-CoA dehydrogenase 19 12891026-12914207 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA043252, HPA048492 Supported Supported Mitochondria Renal cancer:6.79e-8 (favourable), Liver cancer:7.28e-5 (favourable), Lung cancer:3.35e-4 (favourable) Expressed in all Expressed in all liver: 42.8 GFER ALR, ERV1, HERV1, HPO1, HPO2, HSS ENSG00000127554 Growth factor, augmenter of liver regeneration 16 1984207-1987749 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA041227, HPA063553 Approved Validated Mitochondria
Cytosol Renal cancer:4.06e-4 (favourable) Expressed in all Expressed in all small intestine: 51.0 GLDC GCSP, NKH ENSG00000178445 Glycine dehydrogenase (decarboxylating) 9 6532464-6645650 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA002318, HPA052887 Supported Supported Nucleus
Mitochondria Endometrial cancer:5.24e-5 (unfavourable), Renal cancer:3.50e-4 (favourable) Tissue enhanced Tissue enhanced kidney: 58.8;liver: 39.3;placenta: 46.9 cerebral cortex: 18.7 GLUD1 GDH, GLUD ENSG00000148672 Glutamate dehydrogenase 1 10 87050486-87094866 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted secreted proteins Evidence at protein level HPA042492, HPA044839, HPA061369 Approved Supported Mitochondria Renal cancer:1.44e-6 (favourable), Pancreatic cancer:1.76e-5 (unfavourable), Glioma:5.08e-4 (favourable) Expressed in all Expressed in all liver: 457.5 GLUD2 GLUDP1 ENSG00000182890 Glutamate dehydrogenase 2 X 121047588-121050080 Enzymes, Predicted intracellular proteins Evidence at protein level HPA042492, HPA044839, HPA061369 Uncertain Supported Mitochondria Renal cancer:1.98e-4 (favourable) Mixed Tissue enriched 11 testis: 46.3 epididymis: 4.0 GPX4 MCSP, PHGPx ENSG00000167468 Glutathione peroxidase 4 19 1103926-1106791 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB008630, HPA047224, HPA058546 Supported Supported Nucleoplasm
Mitochondria Endometrial cancer:1.84e-5 (favourable), Cervical cancer:7.18e-4 (favourable), Pancreatic cancer:7.72e-4 (favourable), Renal cancer:8.61e-4 (favourable) Expressed in all Expressed in all testis: 1137.7 HADH HADH1, HADHSC, SCHAD ENSG00000138796 Hydroxyacyl-CoA dehydrogenase 4 107989714-108035175 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA039588, HPA043888 Supported Supported Mitochondria Renal cancer:0.00e+0 (favourable) Expressed in all Expressed in all kidney: 188.7 HADHA GBP, LCEH, LCHAD, MTPA ENSG00000084754 Hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 2 26190635-26244726 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA015536, HPA056070 Approved Validated Mitochondria Renal cancer:3.68e-5 (favourable) Expressed in all Expressed in all duodenum: 241.8 IDH2 ENSG00000182054 Isocitrate dehydrogenase 2 (NADP+), mitochondrial 15 90083045-90102504 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA007831 Supported Supported Mitochondria Cervical cancer:5.15e-5 (favourable) Expressed in all Expressed in all skeletal muscle: 450.2 IDH3A ENSG00000166411 Isocitrate dehydrogenase 3 (NAD+) alpha 15 78131498-78171949 Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA041465, HPA062971 Supported Validated Mitochondria Renal cancer:6.49e-8 (favourable) Expressed in all Expressed in all cerebral cortex: 44.3 IDH3B RP46 ENSG00000101365 Isocitrate dehydrogenase 3 (NAD+) beta 20 2658395-2664219 Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA049387, HPA054180 Supported Validated Mitochondria Renal cancer:6.78e-8 (favourable), Liver cancer:1.59e-4 (unfavourable) Expressed in all Expressed in all parathyroid gland: 98.7 IDH3G ENSG00000067829 Isocitrate dehydrogenase 3 (NAD+) gamma X 153785766-153794523 Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA000425, HPA002017 Supported Validated Mitochondria Renal cancer:5.73e-6 (favourable) Expressed in all Expressed in all cerebral cortex: 65.1 IVD ACAD2 ENSG00000128928 Isovaleryl-CoA dehydrogenase 15 40405795-40435947 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA041391, HPA044250 Supported Validated Nucleoplasm
Mitochondria Renal cancer:2.91e-9 (favourable), Liver cancer:1.95e-5 (favourable) Expressed in all Expressed in all thyroid gland: 151.3 L2HGDH C14orf160, FLJ12618 ENSG00000087299 L-2-hydroxyglutarate dehydrogenase 14 50237563-50312548 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA065409, HPA069708 Approved Validated Mitochondria Renal cancer:9.75e-10 (favourable) Expressed in all Mixed kidney: 20.7 MAOA ENSG00000189221 Monoamine oxidase A X 43654907-43746824 Disease related genes, Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level CAB009437, HPA054807, HPA059299 Supported Validated Mitochondria Expressed in all Mixed small intestine: 253.2 MAOB ENSG00000069535 Monoamine oxidase B X 43766611-43882447 Enzymes, FDA approved drug targets, Predicted membrane proteins Evidence at protein level HPA002328, CAB037200 Supported Approved Nucleoli
Mitochondria Expressed in all Mixed seminal vesicle: 213.0 MDH2 ENSG00000146701 Malate dehydrogenase 2, NAD (mitochondrial) 7 76048051-76067508 Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019714, HPA019716, HPA019848, HPA026720 Supported Validated Mitochondria Renal cancer:1.49e-5 (favourable) Expressed in all Expressed in all skeletal muscle: 233.3 ME2 ENSG00000082212 Malic enzyme 2, NAD(+)-dependent, mitochondrial 18 50879049-50954257 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA008247, HPA008880 Supported Validated Mitochondria Liver cancer:8.29e-8 (unfavourable) Expressed in all Expressed in all spleen: 54.3 MECR CGI-63, FASN2B, NRBF1 ENSG00000116353 Mitochondrial trans-2-enoyl-CoA reductase 1 29192873-29230942 Enzymes, Predicted intracellular proteins Evidence at protein level HPA022018, HPA022030, HPA028740 Supported Supported Mitochondria Renal cancer:5.81e-6 (favourable), Urothelial cancer:5.29e-4 (unfavourable) Expressed in all Expressed in all cerebral cortex: 18.4 MT-CO1 COI, COX1, MTCO1 ENSG00000198804 Mitochondrially encoded cytochrome c oxidase I MT 5904-7445 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins, Transporters Evidence at protein level CAB016241, HPA069328 Supported Supported Mitochondria Liver cancer:2.29e-4 (favourable) Expressed in all Expressed in all heart muscle: 79793.3 MT-ND4L MTND4L, NAD4L, ND4L ENSG00000212907 Mitochondrially encoded NADH dehydrogenase 4L MT 10470-10766 Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins Evidence at protein level HPA075648 Approved Mitochondria Liver cancer:4.47e-4 (favourable) Expressed in all Expressed in all heart muscle: 23512.4 NDUFS1 CI-75k ENSG00000023228 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) 2 206114817-206159603 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA064605, CAB070844 Approved Supported Mitochondria Renal cancer:1.47e-12 (favourable), Breast cancer:3.85e-4 (unfavourable) Expressed in all Expressed in all heart muscle: 141.0 NDUFS2 CI-49 ENSG00000158864 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 1 161197104-161214395 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA055140, HPA061953 Supported Validated Nucleoplasm
Mitochondria Renal cancer:2.32e-4 (favourable) Expressed in all Expressed in all heart muscle: 126.4 NDUFS3 CI-30 ENSG00000213619 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 11 47565336-47584562 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA004484 Approved Supported Nuclear bodies
Mitochondria Renal cancer:2.61e-6 (favourable) Expressed in all Expressed in all skeletal muscle: 127.3 NDUFS8 CI-23k, TYKY ENSG00000110717 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 11 68030617-68036644 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA018524 Approved Supported Mitochondria Renal cancer:3.27e-8 (favourable) Expressed in all Expressed in all adrenal gland: 153.3 NDUFV1 CI-51K ENSG00000167792 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 11 67606852-67612535 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA045211, HPA075051 Approved Supported Mitochondria
Cytosol Renal cancer:7.49e-10 (favourable) Expressed in all Expressed in all parathyroid gland: 218.0 NDUFV2 CI-24k ENSG00000178127 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 18 9102630-9134345 Enzymes, Predicted intracellular proteins Evidence at protein level HPA003404, HPA077896 Supported Approved Supported Mitochondria Expressed in all Expressed in all skeletal muscle: 190.9 NNT ENSG00000112992 Nicotinamide nucleotide transhydrogenase 5 43602692-43707405 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins Evidence at protein level HPA004829, CAB004975 Supported Validated Mitochondria Renal cancer:1.22e-15 (favourable) Expressed in all Expressed in all heart muscle: 139.6 OGDH E1k ENSG00000105953 Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 7 44606572-44709066 Citric acid cycle related proteins, Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level HPA019514, HPA020347 Supported Validated Mitochondria Renal cancer:2.22e-14 (favourable) Expressed in all Expressed in all heart muscle: 146.5 P4HA1 C-P4Halpha(I), P4HA ENSG00000122884 Prolyl 4-hydroxylase, alpha polypeptide I 10 73007217-73096974 Enzymes, Plasma proteins, Predicted secreted proteins Evidence at protein level HPA007599, HPA026593 Supported Supported Endoplasmic reticulum
Vesicles
Mitochondria Renal cancer:9.40e-9 (unfavourable), Head and neck cancer:1.19e-5 (unfavourable), Cervical cancer:3.19e-5 (unfavourable), Pancreatic cancer:2.85e-4 (unfavourable), Lung cancer:5.10e-4 (unfavourable), Breast cancer:9.01e-4 (unfavourable) Expressed in all Expressed in all placenta: 91.1 PDHA1 PDHA ENSG00000131828 Pyruvate dehydrogenase (lipoamide) alpha 1 X 19343893-19361705 Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA047487, HPA047864, HPA063053 Approved Supported Mitochondria Renal cancer:1.13e-7 (favourable) Expressed in all Expressed in all heart muscle: 231.0 PDHA2 PDHAL ENSG00000163114 Pyruvate dehydrogenase (lipoamide) alpha 2 4 95840019-95841474 Citric acid cycle related proteins, Enzymes, Predicted intracellular proteins Evidence at protein level HPA047487, HPA047864, HPA063053 Approved Supported Mitochondria Not detected Tissue enriched 1006 testis: 100.5 all non-specific tissues: 0.0 PDHB ENSG00000168291 Pyruvate dehydrogenase (lipoamide) beta 3 58427630-58433857 Citric acid cycle related proteins, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB033794, HPA036744, HPA036745 Supported Supported Nucleoplasm
Mitochondria Renal cancer:2.79e-8 (favourable) Expressed in all Expressed in all heart muscle: 111.5 PPOX PPO, VP ENSG00000143224 Protoporphyrinogen oxidase 1 161166410-161178013 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA030123 Uncertain Approved Mitochondria
Cytosol Renal cancer:9.89e-4 (unfavourable) Expressed in all Expressed in all fallopian tube: 37.3 PRDX1 NKEFA, PAGA ENSG00000117450 Peroxiredoxin 1 1 45511036-45523047 Enzymes, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB004682, HPA007730 Approved Supported Mitochondria Liver cancer:1.17e-5 (unfavourable), Urothelial cancer:2.89e-4 (unfavourable) Expressed in all Expressed in all thyroid gland: 1203.6 PRDX5 ACR1, AOEB166, B166, MGC117264, MGC142283, MGC142285, PLP, PMP20, PRDX6, PRXV, SBBI10 ENSG00000126432 Peroxiredoxin 5 11 64318088-64321811 Enzymes, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins Evidence at protein level CAB008661, HPA037915, HPA037916 Supported Validated Mitochondria
Cytosol Renal cancer:1.24e-5 (favourable) Expressed in all Expressed in all fallopian tube: 599.3 PYCR2 P5CR2 ENSG00000143811 Pyrroline-5-carboxylate reductase family, member 2 1 225919877-225924340 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA056873 Approved Approved Mitochondria Renal cancer:1.42e-6 (unfavourable), Colorectal cancer:5.02e-5 (unfavourable) Expressed in all Expressed in all fallopian tube: 71.0 QDPR DHPR, PKU2, SDR33C1 ENSG00000151552 Quinoid dihydropteridine reductase 4 17460261-17512234 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA058951, HPA065649 Supported Approved Mitochondria Renal cancer:7.84e-6 (favourable) Expressed in all Expressed in all cerebral cortex: 226.9 SARDH DMGDHL1, SDH ENSG00000123453 Sarcosine dehydrogenase 9 133663560-133739955 Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA057267, HPA058086 Supported Approved Mitochondria Glioma:3.50e-4 (unfavourable) Tissue enriched Tissue enhanced epididymis: 58.4;liver: 43.2 kidney: 12.5 SDHA FP, SDH2, SDHF ENSG00000073578 Succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 5 218241-256700 Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins Evidence at protein level CAB034929, HPA041981, HPA064582 Supported Validated Mitochondria Renal cancer:9.53e-8 (favourable), Breast cancer:6.00e-4 (unfavourable) Expressed in all Expressed in all heart muscle: 249.5 SDHB SDH, SDH1 ENSG00000117118 Succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1 17018722-17054170 Cancer-related genes, Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level HPA002868, CAB009822, CAB068233, CAB068234, CAB068235 Supported Supported Nucleoplasm
Plasma membrane
Mitochondria Renal cancer:2.93e-7 (favourable) Expressed in all Expressed in all kidney: 213.3 TMLHE BBOX2, FLJ10727, TMLH, XAP130 ENSG00000185973 Trimethyllysine hydroxylase, epsilon X 155490115-155669944 Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins Evidence at protein level HPA034589, HPA040331 Approved Supported Mitochondria Renal cancer:3.68e-6 (favourable) Expressed in all Expressed in all parathyroid gland: 30.8 TXNRD2 TR, TR3, TRXR2 ENSG00000184470 Thioredoxin reductase 2 22 19875517-19941992 Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins Evidence at protein level CAB002007, HPA003323 Supported Supported Mitochondria
Cytosol Renal cancer:1.10e-7 (favourable) Expressed in all Expressed in all adrenal gland: 34.4 UQCRFS1 RIP1, RIS1, RISP, UQCR5 ENSG00000169021 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 19 29205321-29213541 Enzymes, Predicted intracellular proteins Evidence at protein level HPA041863, HPA050339 Supported Validated Mitochondria Renal cancer:3.92e-9 (favourable), Colorectal cancer:3.29e-4 (favourable), Ovarian cancer:3.84e-4 (unfavourable) Expressed in all Expressed in all skeletal muscle: 70.9