Cell atlas - NDC80 - The Human Protein Atlas

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NDC80

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Nucleoplasm

Human cell
	Centrosome
	Nucleoplasm

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GENERAL INFORMATION
Gene name	NDC80
Gene description	NDC80 kinetochore complex component
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the centrosome.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Centrosome (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA066330
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the centrosome.

Main location

Nucleoplasm (supported)

Additional location

Centrosome (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA066330	RH-30	Nucleoplasm
	HPA066330	U-2 OS	Nucleoplasm
	HPA066330	U-251 MG	Nucleoplasm
	HPA066330	U-251 MG	Centrosome

GENE INFORMATION
Gene name	NDC80 (HGNC Symbol)
Synonyms	HEC, HEC1, hsNDC80, KNTC2, TID3
Description	NDC80 kinetochore complex component (HGNC Symbol)
Entrez gene summary	This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
Chromosome	18
Cytoband	p11.32
Chromosome location (bp)	2571511 - 2616635
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000080986 (version 83.38)
Entrez gene	10403
UniProt	O14777 (UniProt - Evidence at protein level)
neXtProt	NX_O14777
Antibodypedia	NDC80 antibodies

PROTEIN BROWSER

NDC80-001	NDC80-011	NDC80-013	NDC80-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDC80-001 ENSP00000261597 ENST00000261597	O14777 [Direct mapping] Kinetochore protein NDC80 homolog A8K031 [Target identity:100%; Query identity:100%] Kinetochore associated 2, isoform CRA_a; cDNA FLJ77925, highly similar to Homo sapiens kinetochore associated 2, mRNA; cDNA, FLJ93683, Homo sapiens kinetochore associated 2 (KNTC2), mRNA Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000070 [mitotic sister chromatid segregation] GO:0000132 [establishment of mitotic spindle orientation] GO:0000278 [mitotic cell cycle] GO:0000775 [chromosome, centromeric region] GO:0000776 [kinetochore] GO:0000777 [condensed chromosome kinetochore] GO:0000778 [condensed nuclear chromosome kinetochore] GO:0000942 [condensed nuclear chromosome outer kinetochore] GO:0005200 [structural constituent of cytoskeleton] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0007052 [mitotic spindle organization] GO:0007059 [chromosome segregation] GO:0007067 [mitotic nuclear division] GO:0007264 [small GTPase mediated signal transduction] GO:0008608 [attachment of spindle microtubules to kinetochore] GO:0016020 [membrane] GO:0031262 [Ndc80 complex] GO:0042802 [identical protein binding] GO:0051301 [cell division] GO:0051315 [attachment of mitotic spindle microtubules to kinetochore] Show all	642 aa 73.9 kDa	No	0
NDC80-011 ENSP00000461227 ENST00000575515	I3L4G3 [Direct mapping] Kinetochore protein NDC80 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000778 [condensed nuclear chromosome kinetochore] GO:0005200 [structural constituent of cytoskeleton] GO:0051315 [attachment of mitotic spindle microtubules to kinetochore] Show all	141 aa 15.4 kDa	No	0
NDC80-013 ENSP00000476919 ENST00000576274	V9GYM9 [Direct mapping] Kinetochore protein NDC80 homolog Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000778 [condensed nuclear chromosome kinetochore] GO:0005200 [structural constituent of cytoskeleton] GO:0051315 [attachment of mitotic spindle microtubules to kinetochore] Show all	168 aa 18.7 kDa	No	0
NDC80-017 ENSP00000458236 ENST00000574096	I3L0P0 [Direct mapping] Kinetochore protein NDC80 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000778 [condensed nuclear chromosome kinetochore] GO:0005200 [structural constituent of cytoskeleton] GO:0051315 [attachment of mitotic spindle microtubules to kinetochore] Show all	32 aa 3.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.