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Colorectal, prostate and pancreatic cancers displayed moderate to strong membranous staining. A majority of breast, endometrial, urothelial and gastric cancers showed moderate membranous and cytoplasmic staining. Most remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
FXYD3 (HGNC Symbol)
Synonyms
MAT-8, PLML
Description
FXYD domain containing ion transport regulator 3 (HGNC Symbol)
Entrez gene summary
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]