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A few cases of pancreatic and gastric cancers showed moderate to strong cytoplasmic and nuclear positivity. Several adenocarcinomas of lung, papillary adenocarcinoma of thyroid, malignant melanomas and gliomas were moderately stained. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
RGS17 (HGNC Symbol)
Synonyms
RGS-17, RGSZ2
Description
Regulator of G-protein signaling 17 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]