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Group enriched (cerebral cortex, salivary gland, testis, thyroid gland)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression in most tissues
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Renal, liver and endometrial cancers along with several cases of malignant melanomas, colorectal, cervical, ovarian, testicular, pancreatic and urothelial cancers showed moderate to strong cytoplasmic staining with a granular pattern. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
COL9A3 (HGNC Symbol)
Synonyms
DJ885L7.4.1, EDM3, FLJ90759, IDD, MED
Description
Collagen, type IX, alpha 3 (HGNC Symbol)
Entrez gene summary
This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]