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FKBP3

GENERAL INFORMATION

Gene name

 FKBP3

Gene description

 FK506 binding protein 3, 25kDa

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Paired antibodies with high similarity supports the protein expression.

Reliability score

 Supported based on 3 antibodies.
HPA000864 , CAB012232 , CAB012520
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA000864
CAB012232
CAB012520

GENE INFORMATION

Gene name

 FKBP3 (HGNC Symbol)

Synonyms

 FKBP-25, PPIase

Description

 FK506 binding protein 3, 25kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

Chromosome

 14

Cytoband

 q21.2

Chromosome location (bp)

 45115600 - 45135319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000100442 (version 83.38)

Entrez gene

 2287

UniProt

 Q00688 (UniProt - Evidence at protein level)

neXtProt

 NX_Q00688

Antibodypedia

 FKBP3 antibodies

PROTEIN BROWSER
FKBP3-001
FKBP3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP3-001
ENSP00000216330
ENST00000216330
Q00688 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP3
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0044822 [poly(A) RNA binding]
GO:0061077 [chaperone-mediated protein folding]
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 224 aa
25.2 kDa 		No 0
FKBP3-201
ENSP00000379374
ENST00000396062
Q00688 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP3
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Enzymes
   ENZYME proteins
   Isomerase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0044822 [poly(A) RNA binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 224 aa
25.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.