Expression of KNOP1 in cancer - Summary - The Human Protein Atlas

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KNOP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KNOP1
Gene description	Lysine-rich nucleolar protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA041079
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041079

GENE INFORMATION
Gene name	KNOP1 (HGNC Symbol)
Synonyms	101F10.1, C16orf88, FAM191A, TSG118
Description	Lysine-rich nucleolar protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p12.3
Chromosome location (bp)	19701934 - 19718235
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000103550 (version 83.38)
Entrez gene	400506
UniProt	Q1ED39 (UniProt - Evidence at protein level)
neXtProt	NX_Q1ED39
Antibodypedia	KNOP1 antibodies

PROTEIN BROWSER

KNOP1-001	KNOP1-002	KNOP1-003	KNOP1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KNOP1-001 ENSP00000219837 ENST00000219837	Q1ED39 [Direct mapping] Lysine-rich nucleolar protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0044822 [poly(A) RNA binding] Show all	458 aa 51.6 kDa	No	0
KNOP1-002 ENSP00000454329 ENST00000564480	H3BMC9 [Direct mapping] Lysine-rich nucleolar protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		79 aa 8.9 kDa	No	0
KNOP1-003 ENSP00000455369 ENST00000567367	H3BPL4 [Direct mapping] Lysine-rich nucleolar protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		199 aa 22.4 kDa	No	0
KNOP1-005 ENSP00000455015 ENST00000568230	H3BNU8 [Direct mapping] Lysine-rich nucleolar protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.