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CLC

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GENERAL INFORMATION

Gene name

 CLC

Gene description

 Charcot-Leyden crystal galectin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (HMC-1)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (HMC-1)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CLC (HGNC Symbol)

Synonyms

 Gal-10, LGALS10, MGC149659

Description

 Charcot-Leyden crystal galectin (HGNC Symbol)

Entrez gene summary

 Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39731250 - 39738028

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105205 (version 83.38)

Entrez gene

 1178

UniProt

 Q05315 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05315

Antibodypedia

 CLC antibodies

PROTEIN BROWSER
CLC-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLC-001
ENSP00000221804
ENST00000221804
Q05315 [Direct mapping]
Galectin-10
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002667 [regulation of T cell anergy]
GO:0002724 [regulation of T cell cytokine production]
GO:0004622 [lysophospholipase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007275 [multicellular organismal development]
GO:0030246 [carbohydrate binding]
GO:0046006 [regulation of activated T cell proliferation]
GO:0070231 [T cell apoptotic process]
GO:0097153 [cysteine-type endopeptidase activity involved in apoptotic process]
Show all
 142 aa
16.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.