Expression of CAPS in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CAPS
Gene description	Calcyphosine
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (endometrial cancer)
HPA (cell line):	Cell line enhanced (SK-BR-3)
HPA (normal tissue):	Tissue enriched (fallopian tube)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in ciliated cells in respirtatory epithelia and fallopian tube, additional cytoplasmic expression in endometrium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene. Protein expression in respiratory epithelia can be correlated with lung RNA-seq data.
Reliability score	Supported based on 1 antibody. HPA043520
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (endometrial cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA043520

GENE INFORMATION
Gene name	CAPS (HGNC Symbol)
Synonyms	CAPS1, MGC126562
Description	Calcyphosine (HGNC Symbol)
Entrez gene summary	This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	5911707 - 5916208
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105519 (version 83.38)
Entrez gene	828
UniProt	Q13938 (UniProt - Evidence at protein level)
neXtProt	NX_Q13938
Antibodypedia	CAPS antibodies

PROTEIN BROWSER

CAPS-001	CAPS-002	CAPS-004	CAPS-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CAPS-001 ENSP00000465883 ENST00000588776	K7EL21 [Direct mapping] Calcyphosin; Calcyphosine, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	275 aa 30.2 kDa	No	0
CAPS-002 ENSP00000403263 ENST00000452990	Q13938 [Direct mapping] Calcyphosin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0031982 [vesicle] GO:0035556 [intracellular signal transduction] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	248 aa 27 kDa	No	0
CAPS-004 ENSP00000468582 ENST00000588865	K7ES72 [Direct mapping] Calcyphosin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] Show all	134 aa 14.6 kDa	No	0
CAPS-201 ENSP00000484912 ENST00000618299	Q13938 [Direct mapping] Calcyphosin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0031982 [vesicle] GO:0035556 [intracellular signal transduction] GO:0070062 [extracellular exosome] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	189 aa 21 kDa	No	0