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A few cases of squamous cell carcinomas of cervix, lung and skin along with urothelial and thyroid cancers showed moderate to strong cytoplasmic staining. Several cases of malignant melanomas, cholangiocarcinomas, breast, ovarian and testicular cancers along with a few cases of colorectal and pancreatic cancers displayed weak to moderate staining. Inflammatory cells were distinctly stained. Remaining cancers were mainly negative.
This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]