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A majority of cancers showed weak to moderate cytoplasmic positivity, combined with cases of nuclear staining. A few cases of cervical and skin cancers were strongly positive while several gastric and liver cancers were negative.
GENE INFORMATION
Gene name
RNF141 (HGNC Symbol)
Synonyms
ZFP26, ZNF230
Description
Ring finger protein 141 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]