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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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TNR
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  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

TNR

Gene description

Tenascin R

Protein class

Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

Intracellular,Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enhanced (SH-SY5Y, U-937)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in neuropil.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 4 antibodies.
HPA027134 , HPA027150 , HPA029859 , CAB022343
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA027134
HPA027150
HPA029859
CAB022343

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Several renal cancers exhibited weak to moderate cytoplasmic and occasional membranous immunoreactivity. The remaining malignant tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

One case of malignant carcinoid showed strong cytoplasmic immunoreactivity. Remaining malignant tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic and nuclear positivity was observed in several hepatocellular carcinomas while several renal cancers showed moderate cytoplasmic staining. Remaining malignancies were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies were negative. A few cases of skin cancers, malignant gliomas and melanomas displayed moderate cytoplasmic positivity.

GENE INFORMATION

Gene name

TNR

Synonyms

Description

Tenascin R (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The encoded protein is restricted to the central nervous system. The protein may play a role in neurite outgrowth, neural cell adhesion and modulation of sodium channel function. It is a constituent of perineuronal nets. [provided by RefSeq, Aug 2013]

Chromosome

1

Cytoband

q25.1

Chromosome location (bp)

175315194 - 175743770

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000116147 (version 83.38)

Entrez gene

7143

UniProt

Q92752 (UniProt - Evidence at protein level)

neXtProt

NX_Q92752

Antibodypedia

TNR antibodies

PROTEIN BROWSER

TNR-001
TNR-002
TNR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNR-001
ENSP00000356646
ENST00000367674
Q92752 [Direct mapping]
Tenascin-R
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007158 [neuron cell-cell adhesion]
GO:0007411 [axon guidance]
GO:0008306 [associative learning]
GO:0009986 [cell surface]
GO:0010977 [negative regulation of neuron projection development]
GO:0022029 [telencephalon cell migration]
GO:0022408 [negative regulation of cell-cell adhesion]
GO:0030198 [extracellular matrix organization]
GO:0030517 [negative regulation of axon extension]
GO:0035641 [locomotory exploration behavior]
GO:0045121 [membrane raft]
GO:0048692 [negative regulation of axon extension involved in regeneration]
GO:0050804 [modulation of synaptic transmission]
GO:0050805 [negative regulation of synaptic transmission]
GO:0050808 [synapse organization]
GO:0050885 [neuromuscular process controlling balance]
GO:0051968 [positive regulation of synaptic transmission, glutamatergic]
GO:0051971 [positive regulation of transmission of nerve impulse]
GO:0060291 [long-term synaptic potentiation]
GO:0072534 [perineuronal net]
Show all
1358 aa
149.6 kDa
Yes 0
TNR-002
ENSP00000403413
ENST00000422274
H0Y668 [Direct mapping]
Tenascin-R
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
181 aa
19.8 kDa
No 0
TNR-201
ENSP00000263525
ENST00000263525
Q92752 [Direct mapping]
Tenascin-R
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007155 [cell adhesion]
GO:0007411 [axon guidance]
GO:0030198 [extracellular matrix organization]
Show all
1358 aa
149.6 kDa
Yes 0

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