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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACVR2A
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACVR2A

Gene description

Activin A receptor, type IIA

Protein class

Cancer-related genes
Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA046997
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA046997

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed moderate to strong cytoplasmic and membranous immunoreactivity. Several cases of gliomas were weakly stained or negative.

GENE INFORMATION

Gene name

ACVR2A (HGNC Symbol)

Synonyms

ACTRII, ACVR2

Description

Activin A receptor, type IIA (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]

Chromosome

2

Cytoband

Chromosome location (bp)

147844517 - 147930826

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000121989 (version 83.38)

Entrez gene

92

UniProt

P27037 (UniProt - Evidence at protein level)

neXtProt

NX_P27037

Antibodypedia

ACVR2A antibodies

PROTEIN BROWSER

ACVR2A-001
ACVR2A-002
ACVR2A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR2A-001
ENSP00000241416
ENST00000241416
P27037 [Direct mapping]
Activin receptor type-2A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001702 [gastrulation with mouth forming second]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007368 [determination of left/right symmetry]
GO:0007498 [mesoderm development]
GO:0008584 [male gonad development]
GO:0009952 [anterior/posterior pattern specification]
GO:0009966 [regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017002 [activin-activated receptor activity]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030165 [PDZ domain binding]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0030510 [regulation of BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0034711 [inhibin binding]
GO:0042713 [sperm ejaculation]
GO:0043084 [penile erection]
GO:0043235 [receptor complex]
GO:0043621 [protein self-association]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0048706 [embryonic skeletal system development]
GO:0050999 [regulation of nitric-oxide synthase activity]
GO:0060011 [Sertoli cell proliferation]
GO:0071773 [cellular response to BMP stimulus]
Show all
513 aa
57.8 kDa
Yes 1
ACVR2A-002
ENSP00000384338
ENST00000404590
P27037 [Direct mapping]
Activin receptor type-2A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015026 [coreceptor activity]
GO:0016020 [membrane]
GO:0017002 [activin-activated receptor activity]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0071773 [cellular response to BMP stimulus]
Show all
513 aa
57.8 kDa
Yes 1
ACVR2A-201
ENSP00000439988
ENST00000535787
P27037 [Direct mapping]
Activin receptor type-2A
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934 [positive regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0015026 [coreceptor activity]
GO:0017002 [activin-activated receptor activity]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030501 [positive regulation of bone mineralization]
GO:0030509 [BMP signaling pathway]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034673 [inhibin-betaglycan-ActRII complex]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048185 [activin binding]
GO:0071773 [cellular response to BMP stimulus]
Show all
405 aa
45.7 kDa
No 1

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