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Gene name

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Chromosome

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In atlas

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Reliability

Reliability

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Validation

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Searches

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Detectable

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Detectable

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ACLY
  • TISSUE

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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACLY

Gene description

ATP citrate lyase

Protein class

Cancer-related genes
Citric acid cycle related proteins
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in several tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 5 antibodies.
HPA022434 , HPA022953 , HPA022959 , HPA028758 , CAB007783
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ACLY (HGNC Symbol)

Synonyms

ACL, ATPCL, CLATP

Description

ATP citrate lyase (HGNC Symbol)

Entrez gene summary

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

41866908 - 41930542

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000131473 (version 83.38)

Entrez gene

47

UniProt

P53396 (UniProt - Evidence at protein level)

neXtProt

NX_P53396

Antibodypedia

ACLY antibodies

PROTEIN BROWSER

ACLY-001
ACLY-002
ACLY-003
ACLY-004
ACLY-005
ACLY-006
ACLY-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACLY-001
ENSP00000253792
ENST00000352035
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1T9 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006084 [acetyl-CoA metabolic process]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0006629 [lipid metabolic process]
GO:0006633 [fatty acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
1101 aa
120.8 kDa
No 0
ACLY-002
ENSP00000377474
ENST00000393896
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1Y2 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
1091 aa
119.8 kDa
No 0
ACLY-003
ENSP00000466259
ENST00000590151
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1T9 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
1101 aa
120.8 kDa
No 0
ACLY-004
ENSP00000445349
ENST00000537919
P53396 [Direct mapping]
ATP-citrate synthase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
830 aa
91.1 kDa
No 0
ACLY-005
ENSP00000468705
ENST00000592970
K7ESG8 [Direct mapping]
ATP-citrate synthase
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
109 aa
12.3 kDa
No 0
ACLY-006
ENSP00000464717
ENST00000590770
K7EIE7 [Direct mapping]
ATP-citrate synthase
Show all
Predicted intracellular proteins
Citric acid cycle related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
133 aa
14.2 kDa
No 0
ACLY-201
ENSP00000345398
ENST00000353196
P53396 [Direct mapping]
ATP-citrate synthase
A0A024R1Y2 [Target identity:100%; Query identity:100%]
ATP citrate lyase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Citric acid cycle related proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003878 [ATP citrate synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006085 [acetyl-CoA biosynthetic process]
GO:0006101 [citrate metabolic process]
GO:0006112 [energy reserve metabolic process]
GO:0008152 [metabolic process]
GO:0008610 [lipid biosynthetic process]
GO:0009346 [citrate lyase complex]
GO:0015936 [coenzyme A metabolic process]
GO:0016020 [membrane]
GO:0019432 [triglyceride biosynthetic process]
GO:0031325 [positive regulation of cellular metabolic process]
GO:0035338 [long-chain fatty-acyl-CoA biosynthetic process]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0046912 [transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer]
GO:0048037 [cofactor binding]
GO:0070062 [extracellular exosome]
Show all
1091 aa
119.8 kDa
No 0

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The Human Protein Atlas project is funded
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