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Most cancer tissues showed weak to moderate cytoplasmic staining combined with a few cases of nuclear positivity. Strong staining was observed in a few cases of colorectal, ovarian, gastric and liver cancers.
GENE INFORMATION
Gene name
DPF2 (HGNC Symbol)
Synonyms
BAF45d, REQ, ubi-d4
Description
D4, zinc and double PHD fingers family 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]