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Most cancer cells displayed weak to moderate cytoplasmic staining combined with nucleolar or membranous staining in many cases. A few pancreatic cancers were strongly stained. Several hepatocellular carcinomas, lymphomas, stomach and testis cancers were negative.
GENE INFORMATION
Gene name
PHF21A (HGNC Symbol)
Synonyms
BHC80, BM-006, KIAA1696
Description
PHD finger protein 21A (HGNC Symbol)
Entrez gene summary
The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002 [PubMed 12032298]).[supplied by OMIM, Nov 2010]