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Most cancer tissues displayed weak to moderate cytoplasmic immunoreactivity with additional membranous staining in several cases. Lymphomas were negative.
Most cancers displayed weak to moderate cytoplasmic positivity, in several cases accompanied with nucleolar or nuclear membranous staining. Most cases of colorectal and liver cancers along with several gastric and pancreatic cancers were strongly stained.
GENE INFORMATION
Gene name
SORL1 (HGNC Symbol)
Synonyms
C11orf32, gp250, LR11, LRP9, SorLA, SorLA-1
Description
Sortilin-related receptor, L(DLR class) A repeats containing (HGNC Symbol)
Entrez gene summary
This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 (VPS10) domain-containing receptor family, and the low density lipoprotein receptor (LDLR) family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.[provided by RefSeq, Sep 2010]