Expression of MAPKBP1 in cancer - Summary - The Human Protein Atlas

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MAPKBP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAPKBP1
Gene description	Mitogen-activated protein kinase binding protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression combined with nuclear expression in a few cases.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA030832 , HPA030833
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and ovarian cancer (unfavourable).
Endometrial cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030832	HPA030833

GENE INFORMATION
Gene name	MAPKBP1 (HGNC Symbol)
Synonyms	KIAA0596
Description	Mitogen-activated protein kinase binding protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q15.1
Chromosome location (bp)	41774434 - 41827855
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000137802 (version 83.38)
Entrez gene	23005
UniProt	O60336 (UniProt - Evidence at protein level)
neXtProt	NX_O60336
Antibodypedia	MAPKBP1 antibodies

PROTEIN BROWSER

MAPKBP1-001	MAPKBP1-002	MAPKBP1-006	MAPKBP1-008	MAPKBP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAPKBP1-001 ENSP00000397570 ENST00000457542	O60336 [Direct mapping] Mitogen-activated protein kinase-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1508 aa 163.1 kDa	No	0
MAPKBP1-002 ENSP00000393099 ENST00000456763	O60336 [Direct mapping] Mitogen-activated protein kinase-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007256 [activation of JNKK activity] Show all	1514 aa 163.8 kDa	No	0
MAPKBP1-006 ENSP00000426154 ENST00000514566	O60336 [Direct mapping] Mitogen-activated protein kinase-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1231 aa 134.3 kDa	No	0
MAPKBP1-008 ENSP00000422132 ENST00000510535	D6R9F7 [Direct mapping] Mitogen-activated protein kinase-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	156 aa 16.9 kDa	No	0
MAPKBP1-201 ENSP00000487189 ENST00000627631	D6RAI2 [Direct mapping] Mitogen-activated protein kinase-binding protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.