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Prostate and thyroid cancers, most lymphomas and several gliomas, urothelial, renal and pancreatic cancers showed moderate cytoplasmic positivity. Remaining cancer cells were in general weakly stained or negative.
A majority of the cancer cells were weakly stained or negative. Several cases of colorectal, pancreatic, thyroid, prostate and ovarian cancers displayed moderate cytoplasmic positivity.
GENE INFORMATION
Gene name
PPP3CA (HGNC Symbol)
Synonyms
CALN, CALNA, CNA1, PPP2B
Description
Protein phosphatase 3, catalytic subunit, alpha isozyme (HGNC Symbol)
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle] GO:0001975 [response to amphetamine] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0004721 [phosphoprotein phosphatase activity] GO:0004722 [protein serine/threonine phosphatase activity] GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005516 [calmodulin binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005955 [calcineurin complex] GO:0006470 [protein dephosphorylation] GO:0006606 [protein import into nucleus] GO:0006816 [calcium ion transport] GO:0008144 [drug binding] GO:0014883 [transition between fast and slow fiber] GO:0014898 [cardiac muscle hypertrophy in response to stress] GO:0016020 [membrane] GO:0016311 [dephosphorylation] GO:0016787 [hydrolase activity] GO:0019722 [calcium-mediated signaling] GO:0019899 [enzyme binding] GO:0030018 [Z disc] GO:0033173 [calcineurin-NFAT signaling cascade] GO:0033192 [calmodulin-dependent protein phosphatase activity] GO:0033555 [multicellular organismal response to stress] GO:0035562 [negative regulation of chromatin binding] GO:0035690 [cellular response to drug] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042110 [T cell activation] GO:0042383 [sarcolemma] GO:0045087 [innate immune response] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046676 [negative regulation of insulin secretion] GO:0046982 [protein heterodimerization activity] GO:0046983 [protein dimerization activity] GO:0048741 [skeletal muscle fiber development] GO:0050774 [negative regulation of dendrite morphogenesis] GO:0050804 [modulation of synaptic transmission] GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity] GO:0051533 [positive regulation of NFAT protein import into nucleus] GO:0051592 [response to calcium ion] GO:0060079 [excitatory postsynaptic potential] GO:0071333 [cellular response to glucose stimulus] GO:1903244 [positive regulation of cardiac muscle hypertrophy in response to stress]
Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)