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Several colorectal cancers, a few prostate, ovarian and cervical cancers along with a rare case of stomach and pancreatic cancer displayed distinct cytoplasmic positivity in a subset of tumor cells. Remaining cancer cells were negative.
GENE INFORMATION
Gene name
IL22RA1 (HGNC Symbol)
Synonyms
CRF2-9, IL22R
Description
Interleukin 22 receptor, alpha 1 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10BR/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36. [provided by RefSeq, Jul 2008]