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HDGF

GENERAL INFORMATION

Gene name

 HDGF

Gene description

 Hepatoma-derived growth factor

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA048728 , HPA053422 , CAB026035
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), endometrial cancer (unfavourable) and ovarian cancer (favourable).
Liver cancer p<0.001
Endometrial cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA048728
HPA053422
CAB026035

GENE INFORMATION

Gene name

 HDGF (HGNC Symbol)

Synonyms

 HMG1L2

Description

 Hepatoma-derived growth factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q23.1

Chromosome location (bp)

 156742107 - 156766925

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000143321 (version 83.38)

Entrez gene

 3068

UniProt

 P51858 (UniProt - Evidence at protein level)

neXtProt

 NX_P51858

Antibodypedia

 HDGF antibodies

PROTEIN BROWSER
HDGF-001
HDGF-002
HDGF-003
HDGF-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HDGF-001
ENSP00000349878
ENST00000357325
P51858 [Direct mapping]
Hepatoma-derived growth factor
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001222 [transcription corepressor binding]
GO:0003677 [DNA binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008283 [cell proliferation]
GO:0017053 [transcriptional repressor complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
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 240 aa
26.8 kDa 		No 0
HDGF-002
ENSP00000357192
ENST00000368209
P51858 [Direct mapping]
Hepatoma-derived growth factor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001222 [transcription corepressor binding]
GO:0003677 [DNA binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008283 [cell proliferation]
GO:0017053 [transcriptional repressor complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 233 aa
25.5 kDa 		No 0
HDGF-003
ENSP00000357189
ENST00000368206
P51858 [Direct mapping]
Hepatoma-derived growth factor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001222 [transcription corepressor binding]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008283 [cell proliferation]
GO:0009987 [cellular process]
GO:0017053 [transcriptional repressor complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 256 aa
28.3 kDa 		No 0
HDGF-201
ENSP00000443120
ENST00000537739
P51858 [Direct mapping]
Hepatoma-derived growth factor
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0001106 [RNA polymerase II transcription corepressor activity]
GO:0001222 [transcription corepressor binding]
GO:0003677 [DNA binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0008083 [growth factor activity]
GO:0008201 [heparin binding]
GO:0008283 [cell proliferation]
GO:0017053 [transcriptional repressor complex]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0036498 [IRE1-mediated unfolded protein response]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
Show all
 240 aa
26.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.