Expression of ZMYM4 in cancer - Summary - The Human Protein Atlas

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ZMYM4

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ZMYM4
Gene description	Zinc finger, MYM-type 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA051301
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051301

GENE INFORMATION
Gene name	ZMYM4 (HGNC Symbol)
Synonyms	KIAA0425, MYM, ZNF198L3, ZNF262
Description	Zinc finger, MYM-type 4 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	p34.3
Chromosome location (bp)	35268967 - 35422058
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146463 (version 83.38)
Entrez gene	9202
UniProt	Q5VZL5 (UniProt - Evidence at protein level)
neXtProt	NX_Q5VZL5
Antibodypedia	ZMYM4 antibodies

PROTEIN BROWSER

ZMYM4-001	ZMYM4-002	ZMYM4-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ZMYM4-001 ENSP00000322915 ENST00000314607	Q5VZL5 [Direct mapping] Zinc finger MYM-type protein 4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0007010 [cytoskeleton organization] GO:0007275 [multicellular organismal development] GO:0008270 [zinc ion binding] GO:0022604 [regulation of cell morphogenesis] Show all	1548 aa 172.8 kDa	No	0
ZMYM4-002 ENSP00000397524 ENST00000441447	A0A0A0MSN3 [Direct mapping] Zinc finger MYM-type protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.9 kDa	No	0
ZMYM4-003 ENSP00000400506 ENST00000457946	H7C1I7 [Direct mapping] Zinc finger MYM-type protein 4 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	1207 aa 134.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.