Cell atlas - IGFBP3 - The Human Protein Atlas

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IGFBP3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Vesicles

Human cell
	Cytosol
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	IGFBP3
Gene description	Insulin-like growth factor binding protein 3
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to vesicles. In addition localized to the cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (U-2197, U-87 MG)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Additional location	In addition localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB010360
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197, U-87 MG) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to vesicles. In addition localized to the cytosol & nucleoplasm.

Main location

Vesicles (approved)

Additional location

Nucleoplasm (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB010360	A-431	Vesicles
	CAB010360	A-431	Cytosol
	CAB010360	U-2 OS	Nucleoplasm
	CAB010360	U-2 OS	Vesicles

GENE INFORMATION
Gene name	IGFBP3 (HGNC Symbol)
Synonyms	BP-53, IBP3
Description	Insulin-like growth factor binding protein 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	p12.3
Chromosome location (bp)	45912245 - 45921874
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000146674 (version 83.38)
Entrez gene	3486
UniProt	P17936 (UniProt - Evidence at protein level)
neXtProt	NX_P17936
Antibodypedia	IGFBP3 antibodies

PROTEIN BROWSER

IGFBP3-001	IGFBP3-008	IGFBP3-014	IGFBP3-018	IGFBP3-019	IGFBP3-020	IGFBP3-201	IGFBP3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFBP3-001 ENSP00000275521 ENST00000275521	P17936 [Direct mapping] Insulin-like growth factor-binding protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001933 [negative regulation of protein phosphorylation] GO:0001968 [fibronectin binding] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008160 [protein tyrosine phosphatase activator activity] GO:0008285 [negative regulation of cell proliferation] GO:0009968 [negative regulation of signal transduction] GO:0014912 [negative regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0042567 [insulin-like growth factor ternary complex] GO:0043065 [positive regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0045663 [positive regulation of myoblast differentiation] GO:0046872 [metal ion binding] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0070062 [extracellular exosome] Show all	291 aa 31.7 kDa	Yes	0
IGFBP3-008 ENSP00000370476 ENST00000381086	B3KWK7 [Direct mapping] Insulin-like growth factor binding protein 3, isoform CRA_b; Insulin-like growth factor-binding protein 3; cDNA FLJ43234 fis, clone HCHON2002964, highly similar to Insulin-like growth factor-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0005576 [extracellular region] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	194 aa 21.8 kDa	No	0
IGFBP3-014 ENSP00000389668 ENST00000448817	C9JMX4 [Direct mapping] Insulin-like growth factor-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0005576 [extracellular region] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	132 aa 14.9 kDa	No	0
IGFBP3-018 ENSP00000390298 ENST00000428530	H0Y485 [Direct mapping] Insulin-like growth factor-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0005576 [extracellular region] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	143 aa 16.4 kDa	No	0
IGFBP3-019 ENSP00000399116 ENST00000417621	H0Y5K2 [Direct mapping] Insulin-like growth factor-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001968 [fibronectin binding] GO:0005576 [extracellular region] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	153 aa 17.5 kDa	No	0
IGFBP3-020 ENSP00000370473 ENST00000381083	P17936 [Direct mapping] Insulin-like growth factor-binding protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001649 [osteoblast differentiation] GO:0001933 [negative regulation of protein phosphorylation] GO:0001968 [fibronectin binding] GO:0005515 [protein binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0008160 [protein tyrosine phosphatase activator activity] GO:0008285 [negative regulation of cell proliferation] GO:0009968 [negative regulation of signal transduction] GO:0010906 [regulation of glucose metabolic process] GO:0014912 [negative regulation of smooth muscle cell migration] GO:0016942 [insulin-like growth factor binding protein complex] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0040008 [regulation of growth] GO:0042567 [insulin-like growth factor ternary complex] GO:0043065 [positive regulation of apoptotic process] GO:0043085 [positive regulation of catalytic activity] GO:0043410 [positive regulation of MAPK cascade] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] GO:0043568 [positive regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0044342 [type B pancreatic cell proliferation] GO:0045663 [positive regulation of myoblast differentiation] GO:0046872 [metal ion binding] GO:0048662 [negative regulation of smooth muscle cell proliferation] GO:0070062 [extracellular exosome] Show all	297 aa 32.2 kDa	Yes	0
IGFBP3-201 ENSP00000477772 ENST00000613132	A6XND0 [Direct mapping] Insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001968 [fibronectin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	270 aa 29.7 kDa	Yes	0
IGFBP3-202 ENSP00000480717 ENST00000615754	A6XND1 [Direct mapping] Insulin-like growth factor binding protein 3 isoform b; Insulin-like growth factor-binding protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001968 [fibronectin binding] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	263 aa 29 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.