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ADAMTS12
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ADAMTS12

Gene description

ADAM metallopeptidase with thrombospondin type 1 motif, 12

Protein class

Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-2 OS)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending retesting.

Reliability score

Uncertain based on 1 antibody.
HPA035973
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PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA035973

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

A majority of colorectal, breast, liver, gastric and pancreatic cancers displayed weak to moderate cytoplasmic staining. Remaining malignant cells were in general weakly stained or negative.

GENE INFORMATION

Gene name

ADAMTS12

Synonyms

Description

ADAM metallopeptidase with thrombospondin type 1 motif, 12 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

Chromosome location (bp)

33523535 - 33892192

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000151388 (version 83.38)

Entrez gene

81792

UniProt

P58397 (UniProt - Evidence at protein level)

neXtProt

NX_P58397

Antibodypedia

ADAMTS12 antibodies

PROTEIN BROWSER

ADAMTS12-001
ADAMTS12-002
ADAMTS12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADAMTS12-001
ENSP00000344847
ENST00000352040
P58397 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 12
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016477 [cell migration]
GO:0030167 [proteoglycan catabolic process]
GO:0031012 [extracellular matrix]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0050727 [regulation of inflammatory response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071773 [cellular response to BMP stimulus]
GO:1901509 [regulation of endothelial tube morphogenesis]
GO:1902203 [negative regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902548 [negative regulation of cellular response to vascular endothelial growth factor stimulus]
GO:2001113 [negative regulation of cellular response to hepatocyte growth factor stimulus]
Show all
1509 aa
168.5 kDa
Yes 0
ADAMTS12-002
ENSP00000422554
ENST00000504830
P58397 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 12
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016477 [cell migration]
GO:0030167 [proteoglycan catabolic process]
GO:0031012 [extracellular matrix]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0050727 [regulation of inflammatory response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071773 [cellular response to BMP stimulus]
GO:1901509 [regulation of endothelial tube morphogenesis]
GO:1902203 [negative regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902548 [negative regulation of cellular response to vascular endothelial growth factor stimulus]
GO:2001113 [negative regulation of cellular response to hepatocyte growth factor stimulus]
Show all
1594 aa
177.7 kDa
Yes 0
ADAMTS12-003
ENSP00000421638
ENST00000515401
D6REX0 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 12
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
232 aa
26.4 kDa
Yes 0

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