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ADAMTS12

GENERAL INFORMATION

Gene name

 ADAMTS12

Gene description

 ADAM metallopeptidase with thrombospondin type 1 motif, 12

Protein class

 Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-2 OS)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending retesting.

Reliability score

 Uncertain based on 1 antibody.
HPA035973
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035973

GENE INFORMATION

Gene name

 ADAMTS12

Synonyms

Description

 ADAM metallopeptidase with thrombospondin type 1 motif, 12 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

Chromosome location (bp)

 33523535 - 33892192

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000151388 (version 83.38)

Entrez gene

 81792

UniProt

 P58397 (UniProt - Evidence at protein level)

neXtProt

 NX_P58397

Antibodypedia

 ADAMTS12 antibodies

PROTEIN BROWSER
ADAMTS12-001
ADAMTS12-002
ADAMTS12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ADAMTS12-001
ENSP00000344847
ENST00000352040
P58397 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 12
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016477 [cell migration]
GO:0030167 [proteoglycan catabolic process]
GO:0031012 [extracellular matrix]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0050727 [regulation of inflammatory response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071773 [cellular response to BMP stimulus]
GO:1901509 [regulation of endothelial tube morphogenesis]
GO:1902203 [negative regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902548 [negative regulation of cellular response to vascular endothelial growth factor stimulus]
GO:2001113 [negative regulation of cellular response to hepatocyte growth factor stimulus]
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 1509 aa
168.5 kDa 		Yes 0
ADAMTS12-002
ENSP00000422554
ENST00000504830
P58397 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 12
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0006508 [proteolysis]
GO:0007160 [cell-matrix adhesion]
GO:0008233 [peptidase activity]
GO:0008270 [zinc ion binding]
GO:0016477 [cell migration]
GO:0030167 [proteoglycan catabolic process]
GO:0031012 [extracellular matrix]
GO:0032331 [negative regulation of chondrocyte differentiation]
GO:0050727 [regulation of inflammatory response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0071347 [cellular response to interleukin-1]
GO:0071356 [cellular response to tumor necrosis factor]
GO:0071773 [cellular response to BMP stimulus]
GO:1901509 [regulation of endothelial tube morphogenesis]
GO:1902203 [negative regulation of hepatocyte growth factor receptor signaling pathway]
GO:1902548 [negative regulation of cellular response to vascular endothelial growth factor stimulus]
GO:2001113 [negative regulation of cellular response to hepatocyte growth factor stimulus]
Show all
 1594 aa
177.7 kDa 		Yes 0
ADAMTS12-003
ENSP00000421638
ENST00000515401
D6REX0 [Direct mapping]
A disintegrin and metalloproteinase with thrombospondin motifs 12
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
Show all
 232 aa
26.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.