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RNF180

GENERAL INFORMATION

Gene name

 RNF180

Gene description

 Ring finger protein 180

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enriched (RPMI-8226)
HPA (normal tissue):Tissue enhanced (parathyroid gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA006897
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006897

GENE INFORMATION

Gene name

 RNF180

Synonyms

Description

 Ring finger protein 180 (HGNC Symbol)

Entrez gene summary

Chromosome

 5

Cytoband

 q12.3

Chromosome location (bp)

 64165844 - 64372869

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000164197 (version 83.38)

Entrez gene

 285671

UniProt

 Q86T96 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q86T96

Antibodypedia

 RNF180 antibodies

PROTEIN BROWSER
RNF180-001
RNF180-002
RNF180-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RNF180-001
ENSP00000373752
ENST00000389100
Q86T96 [Direct mapping]
E3 ubiquitin-protein ligase RNF180
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
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GO:0000209 [protein polyubiquitination]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016874 [ligase activity]
GO:0030534 [adult behavior]
GO:0031227 [intrinsic component of endoplasmic reticulum membrane]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042415 [norepinephrine metabolic process]
GO:0042428 [serotonin metabolic process]
GO:0050790 [regulation of catalytic activity]
GO:0061630 [ubiquitin protein ligase activity]
GO:1901360 [organic cyclic compound metabolic process]
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 592 aa
68.3 kDa 		No 1
RNF180-002
ENSP00000296615
ENST00000296615
Q86T96 [Direct mapping]
E3 ubiquitin-protein ligase RNF180
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Predicted intracellular proteins
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GO:0000209 [protein polyubiquitination]
GO:0005635 [nuclear envelope]
GO:0008270 [zinc ion binding]
GO:0016021 [integral component of membrane]
GO:0016874 [ligase activity]
GO:0030534 [adult behavior]
GO:0031227 [intrinsic component of endoplasmic reticulum membrane]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0032436 [positive regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0042415 [norepinephrine metabolic process]
GO:0042428 [serotonin metabolic process]
GO:0061630 [ubiquitin protein ligase activity]
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 416 aa
47.3 kDa 		No 0
RNF180-003
ENSP00000426884
ENST00000504296
D6RE88 [Direct mapping]
E3 ubiquitin-protein ligase RNF180
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Predicted intracellular proteins
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 107 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.