Expression of SPZ1 in cancer - Summary - The Human Protein Atlas

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SPZ1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	SPZ1
Gene description	Spermatogenic leucine zipper 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (prostate cancer, testis cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (prostate cancer, testis cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	SPZ1 (HGNC Symbol)
Synonyms	FLJ25709, NYD-TSP1, PPP1R148
Description	Spermatogenic leucine zipper 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a bHLH-zip transcription factor which functions in the mitogen-activate protein kinase (MAPK) signaling pathway. Because of its role in the upregulation of cell proliferation and tumorigenesis, this gene may serve as a target for Ras-induced tumor treatments. [provided by RefSeq, Oct 2011]
Chromosome	5
Cytoband	q14.1
Chromosome location (bp)	80319625 - 80321842
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000164299 (version 83.38)
Entrez gene	84654
UniProt	Q9BXG8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BXG8
Antibodypedia	SPZ1 antibodies

PROTEIN BROWSER

SPZ1-001	SPZ1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPZ1-001 ENSP00000369611 ENST00000296739	Q9BXG8 [Direct mapping] Spermatogenic leucine zipper protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] Show all	430 aa 49.4 kDa	No	0
SPZ1-003 ENSP00000426530 ENST00000511881	D6RFL8 [Direct mapping] Spermatogenic leucine zipper protein 1 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Show all	GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] Show all	234 aa 26.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.