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TNFRSF11B
  • TISSUE

  • CELL

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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

TNFRSF11B

Gene description

Tumor necrosis factor receptor superfamily, member 11b

Protein class

Cancer-related genes
Candidate cardiovascular disease genes
Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (BJ, BJ hTERT+)
HPA (normal tissue):Tissue enriched (thyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Prognostic marker in urothelial cancer (unfavourable), cervical cancer (unfavourable) and renal cancer (favourable).
Urothelial cancer p<0.001
Cervical cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

TNFRSF11B (HGNC Symbol)

Synonyms

OCIF, OPG, TR1

Description

Tumor necrosis factor receptor superfamily, member 11b (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q24.12

Chromosome location (bp)

118923557 - 118952200

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164761 (version 83.38)

Entrez gene

4982

UniProt

O00300 (UniProt - Evidence at protein level)

neXtProt

NX_O00300

Antibodypedia

TNFRSF11B antibodies

PROTEIN BROWSER

TNFRSF11B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF11B-001
ENSP00000297350
ENST00000297350
O00300 [Direct mapping]
Tumor necrosis factor receptor superfamily member 11B
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001501 [skeletal system development]
GO:0004872 [receptor activity]
GO:0005031 [tumor necrosis factor-activated receptor activity]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007584 [response to nutrient]
GO:0010035 [response to inorganic substance]
GO:0030198 [extracellular matrix organization]
GO:0032026 [response to magnesium ion]
GO:0032496 [response to lipopolysaccharide]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042127 [regulation of cell proliferation]
GO:0042489 [negative regulation of odontogenesis of dentin-containing tooth]
GO:0042493 [response to drug]
GO:0042981 [regulation of apoptotic process]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043627 [response to estrogen]
GO:0045779 [negative regulation of bone resorption]
GO:0046685 [response to arsenic-containing substance]
GO:0097190 [apoptotic signaling pathway]
Show all
401 aa
46 kDa
Yes 0

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