Fields »
ABOUT
HELP
BLOG
CDC42EP5

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 CDC42EP5

Gene description

 CDC42 effector protein (Rho GTPase binding) 5

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Not detected

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 CDC42EP5 (HGNC Symbol)

Synonyms

 Borg3, CEP5

Description

 CDC42 effector protein (Rho GTPase binding) 5 (HGNC Symbol)

Entrez gene summary

 Cell division control protein 42 (CDC42), a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg (binder of Rho GTPases) family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to CDC42 and regulate its function negatively. The encoded protein may inhibit c-Jun N-terminal kinase (JNK) independently of CDC42 binding. The protein may also play a role in septin organization and inducing pseudopodia formation in fibroblasts [provided by RefSeq, Jul 2013]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 54465026 - 54473264

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167617 (version 83.38)

Entrez gene

 148170

UniProt

 Q6NZY7 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q6NZY7

Antibodypedia

 CDC42EP5 antibodies

PROTEIN BROWSER
CDC42EP5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CDC42EP5-001
ENSP00000301200
ENST00000301200
Q6NZY7 [Direct mapping]
Cdc42 effector protein 5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007254 [JNK cascade]
GO:0007266 [Rho protein signal transduction]
GO:0008360 [regulation of cell shape]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0017049 [GTP-Rho binding]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0043547 [positive regulation of GTPase activity]
Show all
 148 aa
15.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.