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LSM3

GENERAL INFORMATION

Gene name

 LSM3

Gene description

 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA044966
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044966

GENE INFORMATION

Gene name

 LSM3 (HGNC Symbol)

Synonyms

 SMX4, USS2, YLR438C

Description

 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated (HGNC Symbol)

Entrez gene summary

 Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]

Chromosome

 3

Cytoband

 p25.1

Chromosome location (bp)

 14178358 - 14201119

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000170860 (version 83.38)

Entrez gene

 27258

UniProt

 P62310 (UniProt - Evidence at protein level)

neXtProt

 NX_P62310

Antibodypedia

 LSM3 antibodies

PROTEIN BROWSER
LSM3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LSM3-001
ENSP00000302160
ENST00000306024
P62310 [Direct mapping]
U6 snRNA-associated Sm-like protein LSm3
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005688 [U6 snRNP]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0033962 [cytoplasmic mRNA processing body assembly]
GO:0043928 [exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071011 [precatalytic spliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:1990726 [Lsm1-7-Pat1 complex]
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 102 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.