Fields »
ABOUT
HELP
BLOG
RCC2

GENERAL INFORMATION

Gene name

 RCC2

Gene description

 Regulator of chromosome condensation 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA072281
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), renal cancer (unfavourable), melanoma (unfavourable) and cervical cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
Melanoma p<0.001
Cervical cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA072281

GENE INFORMATION

Gene name

 RCC2 (HGNC Symbol)

Synonyms

 TD-60

Description

 Regulator of chromosome condensation 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 1

Cytoband

 p36.13

Chromosome location (bp)

 17406760 - 17439724

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000179051 (version 83.38)

Entrez gene

 55920

UniProt

 Q9P258 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P258

Antibodypedia

 RCC2 antibodies

PROTEIN BROWSER
RCC2-001
RCC2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RCC2-001
ENSP00000364585
ENST00000375436
Q9P258 [Direct mapping]
Protein RCC2
A0A024RAC5 [Target identity:100%; Query identity:100%]
Regulator of chromosome condensation 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007067 [mitotic nuclear division]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010762 [regulation of fibroblast migration]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030334 [regulation of cell migration]
GO:0030496 [midbody]
GO:0031267 [small GTPase binding]
GO:0031901 [early endosome membrane]
GO:0034260 [negative regulation of GTPase activity]
GO:0034506 [chromosome, centromeric core domain]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0048041 [focal adhesion assembly]
GO:0048365 [Rac GTPase binding]
GO:0051301 [cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0072356 [chromosome passenger complex localization to kinetochore]
GO:0090630 [activation of GTPase activity]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1900027 [regulation of ruffle assembly]
GO:1990023 [mitotic spindle midzone]
Show all
 522 aa
56.1 kDa 		No 0
RCC2-002
ENSP00000364582
ENST00000375433
Q9P258 [Direct mapping]
Protein RCC2
A0A024RAC5 [Target identity:100%; Query identity:100%]
Regulator of chromosome condensation 2, isoform CRA_a
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0007067 [mitotic nuclear division]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008017 [microtubule binding]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016020 [membrane]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0030334 [regulation of cell migration]
GO:0030496 [midbody]
GO:0031267 [small GTPase binding]
GO:0034260 [negative regulation of GTPase activity]
GO:0034506 [chromosome, centromeric core domain]
GO:0044822 [poly(A) RNA binding]
GO:0048041 [focal adhesion assembly]
GO:0048365 [Rac GTPase binding]
GO:0051301 [cell division]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051987 [positive regulation of attachment of spindle microtubules to kinetochore]
GO:0072356 [chromosome passenger complex localization to kinetochore]
GO:1900025 [negative regulation of substrate adhesion-dependent cell spreading]
GO:1990023 [mitotic spindle midzone]
Show all
 522 aa
56.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.